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Accupain (Tramadol)

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Accupain is used to help relieve moderate to moderately severe pain. Accupain is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Acema, Armadol, Axedol, Bolodol, Combitram, Cormadol, Damol, Decotram, Dolex, Dolodol, Doltel, Drobit, Euphodol, Formador, Ibudol, Madol, Mandol, Mobiya, Muzox, Mydol, Neutram, Nomadol, Nosdol, Omodol, Opidol, Radol, Ramax, Ramcet, Relidol, Rybix, Servodol, Siatram, Sigmadol, Stemadol, Supridol, Tacil, Taxidol, Traiz, Tramaflam, Tramoflex, Tramospas, Tramot, Transic, Trapain, Trofel, Tryme, Ultrazac, Vegadol

Similar Products:
Calan, Flonase, Cialis, Geodon, Noroxin, Terramycin, Lipitor, Clarinex, Estilo, Neuroage, Terogood, Coolam, Cefpodoximum, Neviraprine,

Also known as: Tramadol


Accupain ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Accupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Accupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Accupain dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Accupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Accupain ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Accupain ER should not be given to a child younger than 12 years old. Accupain ER should not be given to anyone younger than 18 years old.

Do not give Accupain ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Accupain ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Accupain ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Accupain ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Vascular calcification (VC) is common in CKD, but little is known about its prognostic effect on patients with nondialysis CKD. This in turn is relevant to the biopharmaceutical industry for monitoring the integrity of disulfide bridges near the protein C terminus. Correlation of serum HCV core concentration with blood level of lipid and antioxidants in various forms of liver diseases. Monitoring of transcriptional regulation in Pichia pastoris under protein production conditions. By interacting with Ku70, p18-cyclin E liberates Bax, which participates in the amplification of apoptosis by sustaining a positive feedback loop targeting mitochondria. Adding a spice mix diovan hct mg to hamburger meat prior to cooking resulted in a reduction in urinary malondialdehyde, an increase in urinary nitrate/nitrite and improvement of postprandial endothelial dysfunction in men with Type 2 diabetes. The structural changes during spermiogenesis were studied on developing spermatids in seminal vesicles and receptacles of Lumbricus terrestris fixed in glutaraldehyde-osmium tetroxide and embedded in Epon-Araldite.

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We examined the possibility of nonconscious associative learning in a context of skin conductance conditioning, using emotional facial expressions as stimuli. While studying the biological activity of 1,25(OH)2D3, we observed that under certain circumstances 1,25-(OH)2D3 would decrease the serum phosphorus concentration. On recording from 439 SEF neurons, we found that two aspects of neuronal activity were influenced by the nature of the cue. No bone metastases existed, which is the most frequent way of tumours extension towards leptomeninges. It is suggested that object files encode postcategorical information, rather than precise physical information. This paper briefly traces the history of health education and promotion, with particular emphasis on the way people have dealt with accountability in the past as a platform for the future. In contrast to the variability in UVACs, the relatively homogeneous values of Fv/Fm and the lack of any DNA damage made these variables useless for ambient UV biomonitoring, but suggested a strong acclimation capacity of this liverwort to changing environmental conditions (in particular, to UV levels). ON THE REACTION OF THE SPINAL CORD TO THE STIMULATION OF PROPRIORECEPTORS IN LOCAL COOLING OF EXTREMITIES. Women with high-ADA activity and low-ACP1 activity, on the contrary, show the highest susceptibility to RSA and also the highest incidence of auto antibodies and of A blood group incompatibility. Its skeletal metastasis is less frequent, particularly when solitary.

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Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches. At low plant nutrient contents, the impact of herbivores is mediated by the mineralization/immobilization of nutrients by decomposers and by the type of resource limiting the growth of decomposers. However, the uncoupling of that symbiotic relation is not concomitant with the initial stress response of heat shock protein synthesis. Addition of f-10 increased MRI sensitivity to detect LN metastasis in advanced cervical cancer. The rates for successful visualization of each nerve for 3D CISS (and for T2-weighted FSE in parentheses) were as follows: NI, NII, NV, NVII, NVIII 40 of 40 (40 of 40), NIII 40 of 40 (18 of 40), NIV 19 of 40 (3 of 40), NVI 39 of 40 (5 of 40), NIX, X, XI 40 of 40 (29 of 40), and NXII 40 of 40 (4 of 40). Changes of the coronary vessels induced by posthypophysial hormones. Specialty areas of focus included the potential for broader application of transcranial Doppler and hydroxyurea therapy in sickle cell disease, African-specific guidelines for transfusion support of cancer patients, the challenges of transfusion support in trauma, and the importance of African-centered clinical research in pediatric and obstetric transfusion medicine. Lack of dosage compensation accompanies the arrested stage of sex chromosome evolution in ostriches. Preliminary studies suggest that biological factors may be used as efficient predictors within the next few years but they are still under evaluation and therefore are not to be used in routine practice. All DNT patients who underwent lesionectomy and resection of the epileptogenic cortex became seizure-free or had their seizure significantly reduced a mean follow-up period of 41.5 months.

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The most striking spots on Coomassie-stained two-dimensional gels belong to GsiB and GspA, which are synthesized at extremely high levels in response to different stresses. Recurrent acute pancreatitis in a patient with wirsungocele and neuroendocrine tumor of ampulla of Vater. Compliance treatment and its clinical correlates were assessed at the end of 2-year follow-up in 200 patients meeting Research Diagnostic Criteria for bipolar I or bipolar II disorder by means of compliance-focused interviews, measurements of plasma concentrations of mood stabilizers, and 2 structured interviews: the Schedule for Affective Disorders and Schizophrenia and the Structured Clinical Interview for DSM-III-R Axis II disorders. Our knowledge of distribution and diversity of insect non-LTR retrotransposons is limited to a few species - mainly model organisms such as dipteran genera Drosophila, Anopheles, and Aedes. We retrospectively reviewed the olfactory outcome in patients with OGM and investigated cozaar medication side effect the factors associated with sparing the post-operative olfaction. Mitral valve surgery can be safely performed in most elderly patients with severe mitral regurgitation. Aspirin, acetylated SA, is a major nonsteroidal anti-inflammatory drug (NSAID) because it inhibits COX activity in humans.

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