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Acema (Tramadol)

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Acema is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Acema is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Arrestadol, Cosdol, Dolfre, Dolotram, Drobit, Gemodol, Haledol, Inodol, Lagesic, Madol, Mandol, Nopidol, Nosdol, Orchidol, Oshdol, Pacadon, Painadol, Postadol, Rybix, Ryzolt, Sedate, Spasteez, Takol, Tamody, Tolydol, Tramaflam, Tramared, Tramatas, Tramed, Tramol, Trazac, Trectadol, Trofel, Tromfil, Vegadol, Xtram

Similar Products:
Lozol, Mestinon, Rhinocort, Cymbalta, Robaxin, Panpot, Flutiriv, Inedol, Oranex, Dalcap, Esivan, Ompicid, Syntac,

Also known as: Tramadol


Acema (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Acema is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Acema ER) is for around-the-clock treatment of pain. Acema ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acema ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acema ER.

Never share Acema ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acema ER.

Acema ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acema ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acema ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acema ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acema ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acema are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Acema if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Acema should not be given to a child younger than 12 years old. Acema ER should not be given to anyone younger than 18 years old.

Do not give Acema to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Acema. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Acema is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Intracellular signaling and genetic reprogramming during agonist-induced hypertrophy of cardiomyocytes. A NOTE ON THE OBSERVATION ON THE REAPPEARANCE OF MICROFILARIA BANCROFTI IN CASES TREATED WITH DIETHYL-CARBAMAZINE IN DOSES SCHEDULED UNDER THE NATIONAL FILARIA CONTROL PROGRAMME. To determine a minimal sequence in GS that provides for high-level virus assembly, we have generated a series of recombinant DeltaG-VSVs which express chimeric glycoproteins having truncated stem sequences. Atherosclerotic arterial remodeling has been described in the coronary circulation but has not been studied extensively for carotid atherosclerosis. Osteopenia and osteoporosis in pediatric patients after stem cell transplant. The mitochondrial genome encodes 13 polypeptides that are components of oxidative phosphorylation to produce energy.

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Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes. Affective disorders in all forms do occur in persons with mental retardation. Taken together with our previous results, this study suggests that the activation of p34cdc2 coordinates the mitotic reorganization of the vimentin IF network both by severing IF-IF connections mediated by IFAP 300 and by disassembling individual IFs into protofilaments. They deal briefly with possibilities of their medicamentous treatment with regard to the pharmacological action of prokinetics. Clot-inducing substances present in snake venoms with particular reference to Echis carinatus. Finally, we offer a set of recommendations aimed at maximizing the organ donor pool while safeguarding the interests of potential living donors. To examine whether interspinous distraction procedures are used selectively in patients with more advanced age or comorbidity, and whether they are associated with fewer complications, lower costs, and less revision surgery than laminectomy or fusion surgery.

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Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis. DYNAMICS OF CUTANEOUS GALVANIC REACTIONS IN PATIENTS WITH SECONDARY ERUPTIONS. Three of these families represent extremely distant homologs (DUF506, DUF524, and YhgA-like), while two are newly defined in updated database (DUF1626 and DUF1703). This system, for use in the testing of radiosensitisers, allows a quantitative estimate of enhancement of response to be made. The present study was undertaken to determine the effect of oral perindopril, 2 mg/kg, on systemic and regional hemodynamics by the radioactive microsphere (15 mu in conscious rats with chronic heart failure and falsely operated-on rats. We also investigated 28 pediatric dialysis patients who showed growth retardation and delayed puberty.

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Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner. New findings on adrenal cortex activity in total-body irradiated rats. Characterization of cotJ, a sigma E-controlled operon affecting the polypeptide composition of the coat of Bacillus subtilis spores. These results demonstrate that the study of immune systems can reveal the presence of toxic substances with varying degrees of toxicity. Rates of interaction directly explained variation in the gut microbiome, even after controlling for diet, kinship, and shared environments. The loss-of-resistance technique, a simple nonsurgical (percutaneous) technique, was used to locate the epidural space.

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Changes in urinary excretion of free catecholamines (CA) in healthy children in different age groups. Alteration of cytokine production in follicular cystic ovaries induced in mice by neonatal estradiol injection. Effects of U0126 on growth and activation of mitogen-activated protein kinases in Aspergillus fumigatus. Hepatic resections for non-colorectal, non-neuroendocrine metastases. A rapid, simple and sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid-induced fluorescence.

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Poliovirus neutralizing titers were determined in poliovirus microneutralization assay. Current safety and efficacy data justify further investigation of once-weekly dosing of alendronate. Furthermore, a short C-terminal fragment shows homology to a part of chitinase A of Vibrio harveyi. Preliminary studies show BF2 dbm(I)PLA-mPEG nanoparticle accumulation in a window chamber mammary tumor 24 h after IV injection into mice (C57Bl/6 strain) enabling tumor oxygen imaging. An epidemiologist can recognize differences in hypertensive candidates for cardiovascular disease based on their cardiovascular risk profile rather than relying solely on the character of the blood pressure elevation. Furthermore, we combine these tests with both iAAFT and truncated Fourier transform (TFT) surrogate methods, which also preserves the nonstationarity of the original data in the cordarone 200 mg tabletten surrogates along with its linear structure. The VL genes were initially coupled to a synthetic C kappa gene. To evaluate the use of oral acyclovir in pediatric patients with herpes simplex virus (HSV) keratitis. Accessory diaphragm associated with neonatal respiratory distress. The duodenum was cut across, 1-2 cm above the lower border of the ulcer.

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The proposed model of action potential generation in electroexcitable membranes is based on physical phenomenon of the reversible thermal dielectric breakdown induced by injection of the activating charge carriers in the membrane under irritation. However, to our knowledge, no studies have comprehensively investigated the role of geographic location in the match process. Osteogenic and adipogenic potential of porcine adipose mesenchymal stem cells. This paper presents a new clustering protocol for designing energy-efficient hierarchical wireless sensor networks (WSNs) by dividing the distributed sensor network into virtual sensor groups to satisfy the scalability and prolong the network lifetime in large-scale applications. We therefore propose the more logical name USS1 (U-Six SnRNP) for this gene. We evaluated 30 patients with documented medial temporal lobe epilepsy to determine if prediction of postoperative outcome is improved with the use of positron emission tomography with (18)fluorodeoxyglucose.

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