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Adiff (Adapalene)

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Adiff is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Adiff belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Celexa, Lamictal, Thorazine, Dostinex, Nolvadex, Requip, Hondrea, Chloromycetin, Altezym, Protopan, Hilos,

Also known as: Adapalene


Adiff (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Adiff is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.


Follow the directions for using this medicine provided by your doctor. Use Adiff exactly as directed. Adiff is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adiff. Adiff should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adiff. Continue using Adiff until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adiff promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


If you overdose Adiff and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adiff dosage information

Side effects

The most common side effects associated with Adiff are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Adiff if you are allergic to Adiff components. It is not known whether Adiff will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Adiff in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Adiff, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Adiff. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Adiff suddenly.

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Contentious issues in research on trafficked women working in the sex industry: study design, ethics, and methodology. Poetic autoethnography provides a research methodology to explore yoga as a mind-body intervention that creates sanctuary. A new delivery formulation (5FU-MS) of 5-fluorouracil (5FU), 5FU incorporated in microspheres composed of poly(glycolide-co-lactide) matrix, has been developed for the treatment of peritoneal carcinomatosis, and is designed to slowly release the incorporated 5FU for 3 weeks. UPC2 deletion has opposite effects on IXR1 and ROX1 transcription during hypoxia. Here we used a broad panel of long synthetic peptides of defined tumor antigens and normal tissue antigens to exploit a newly developed method to identify and compare ex vivo the antigen specificities of Tregs with those of effector/memory T cells in peripheral blood of colorectal cancer patients and healthy subjects. The specificity of the double duct sign in predicting the presence of pancreatic cancer appears to be lower than previously reported. Bugs and marginal zone lymphoma of the ocular adnexae: is the future already here?. Social support and employment status interact with IPV on the severity of depressive symptoms in women.

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Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling. Pre-incubation with anti-HSP70 antibody and miRNA silencing of HSP70 significantly reduced the CHIKV production in HEK-293T and Vero-E6 cells at early time points. Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial. The data demonstrated a substantial effect of gamma-irradiation on initial molecular weight distribution and onset of mass loss for PLGA, but no effect on rate of mass loss. Supplemental protein sources for steers fed corn-based diets: II.

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Chromosome studies of an infant with acute myeloblastic leukemia (AML), classified as M2 in the FAB nomenclature revealed an unusual karyotype with del(11)(q23) and a marker chromosome resembling a small chromosomal fragment present in all metaphase cells examined. Expression of inducible nitric oxide synthase in paired neoplastic and non-neoplastic primary prostate cell cultures and prostatectomy specimen. To trace the development of the high-level writing processes of planning and revising, from Grades 4 to 9, and to examine whether these skills predict writing quality in younger and older students (Grades 4-6 vs. Binding of Escherichia coli integration host factor (IHF) to the origin segment of p15A plasmid. Recently there was an increased interest towards network approach to biology and environmental sciences. Hemostatic breakdown, fibrinolysis, and acquired hemolytic anemia in a patient with fatal heatstroke: pathogenetic mechanisms. 1alpha, 25-dihydroxy-vitamin D3 alters Syk activation through FcgammaRII in monocytic THP-1 cells. Analyses of both species using 3D reconstructions of developing molars and jaws, computational modeling of cusp patterning, and tooth explants cultured with small braces show that correct cusp offset requires constraints on the lateral expansion of the developing tooth. Transfection of an alpha(v)-integrin-deficient cell line with a plasmid that expresses alpha(v)beta5 resulted in Ad9 binding that was not significantly blocked by F9K but was blocked with a combination of F9K and penton base.

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Successful treatment of rhinocerebral mucormycosis with liposomal amphotericin B and surgery in two diabetic patients with renal dysfunction. Molecular mechanisms of viral immune evasion proteins to inhibit MHC class I antigen processing and presentation. The architecture of an inhibitory sidepath within the avian tectofugal system. Although the mean scores showed somewhat low levels of moral distress, the range of responses revealed that some nurses experienced high levels of moral distress with the issues. Although nonvenereal syphilis (bejel) has been reported to be endemic in some of these countries, the extent of treponematoses in the UAE is unknown. Surgical resection of the right lung would probably have been difficult because of the almost complete collapse of the right lung and the extensive calcifications within the right hemithorax. These observations indicate that there may be major differences in the mode of action of MCH between fish and mammals. In order to study this inconsistency we have reconstructed phylogenetic trees based on data sets of 20 orthologous nuclear protein coding genes (6441 aa, sites) and 12 mitochondrial protein coding genes (3559 aa sites).

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Despite declines in prevalence of other key major cardiovascular disease risk factors, the prevalence of overweight and obesity has reached epidemic proportions and it continues to rise. Computed tomographic-guided FNA does not appear to increase the risk for positive peritoneal washings and represents a valid approach to the pretreatment diagnosis of patients with suspected pancreatic malignancy. Collagen type III content, elastin content, and number and mitotic activity of fibroblasts were not significantly different between the control and POP groups. Reexamination of whether and how maternal and paternal depression serve as environmental risk factors is important because such an investigation can be helpful to identify modifiable allegra 24 hour allergy 180 mg tablets mechanisms that are accessible to interventions. We term this method SuperMatrix Rooted Triple (SMRT) and use the notation SMRT-ML when rooted triples are inferred by ML.

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