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Afdiex (Glibenclamide)

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Afdiex is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. The usual starting dose of Afdiex as initial therapy is 2.5 to 5 mg by mouth once daily with breakfast or the first main meal.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Comdiab, Daocon, Diabnil, Diolin, Duotrol, Dutrol, Giclamide, Glibson, Glifil, Glimsug, Glinil, Glitrac, Glucosil, Glucotrac, Glutowin, Glybenclamide, Glyboral, Glybovin, Glybovine, Melitus, Pionorm, Secrin, Sugatrol, Sugnil, Symet, Triglycomet

Similar Products:
Aurogra, Dilantin, Noroxin, Parlodel, Ambien, Clomid, Sovaldi, Xeloda, Coecoral, Ethidan, Kefnir, Omsat, Nimocer,

Also known as: Glibenclamide


Afdiex is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Afdiex belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Afdiex overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Afdiex dosage information

Side effects

The most common side effects associated with Afdiex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to Afdiex, micronized or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Cytolytic activity of TNF was analysed at L929 and K562 tumor cell lines. The algorithm first performs an automatic segmentation of the eyes on specific reference images. While very few randomized clinical trials have been conducted with prostate cancer patients, recent results suggest that such interventions improve coping skills, increase prostate cancer knowledge, reduce treatment-related disruption of daily activities, diminish bother associated with sexual problems and enhance global quality of life. Medical management of nasal polyposis: a study in a series of 152 consecutive patients. Antitumor immunity in cancer patients is heavily modulated by cells of the innate immune system. In both baboon and monkey sperm, the acrosomal region had the highest intensity stain and the equatorial region had the lowest intensity.

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We used enriched marrow cells from mice administered three doses of 150 mg/kg 5-fluorouracil (5-FU) 1, 3 and 7 days before they were killed to study the effects of different growth factors on the survival of primitive, cell-cycle dormant progenitors in culture. This article reviews the current body of evidence regarding the cardiovascular effects of celecoxib, considered under two distinct, but non-mutually exclusive, headings: cardiorenal and thromboembolic. Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Post-specific fiber diameter, fiber arrangement over the cross-sections and length, and fiber-matrix ratio could be associated with mechanical properties, such as three-point bending strength and structure modulus. Together, our results reveal myeloid cells in the bone marrow as an important source of Wnt10b under complex hormonal and cytokine regulation. A well-known hallmark of GMB and many other tumours is aerobic glycolysis. Levels of a few serum and urinary hormones/metabolites viz., serum testosterone, total triiodothyronine (T3) and thyroxine (T4) and urinary total 17-ketosteroids (17-KS), estrone, estradiol, and 17-hydroxy corticosteroids (17-OHCS) were assessed in alcoholics thrice during the treatment programme at hospital i.e., on the zero (day of admission), 10th, and 20th day and compared to those of non-alcoholic controls. To assess the risk of death associated with work based and non-work based measures of socioeconomic status before and after retirement age.

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Hemodynamic deterioration after cardiopulmonary bypass during pregnancy: resuscitation by postoperative emergency Cesarean section. Final apical shaping is easily achieved when root length is reached. Interviews were analysed using rigorous methods drawn from grounded theory. Biological activity of collagen-bound PDGF was demonstrated by a 1.5-3-fold stimulation of proliferation of human fibroblasts and mouse 3T3 cells. STSG thickness is inconsistent, with a broad spread about a median value.

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Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. Trends in average weights and heights for men: an insurance experience. Although teenage males were willing to date girls slightly younger than themselves, they indicated a much wider range of acceptability above their own ages, and also reported that their ideally attractive partners would be several years older than themselves. Since then it has been used numerous times in a large variety of settings to extrapolate from finite size systems to the infinite system in a large variety of situations in statistical mechanics. We retrospectively reviewed 107 patients of upper urinary tract carcinoma to determine the overall outcome, prognostic factors, frequency of subsequent bladder cancer and role of adjuvant therapy. The intervention consisted of a two-hour low-GI dietary education session in early pregnancy. This indicates that the mammalian species included in this study probably share only one common ancestor IGHG gene with the horse. The effect of physico-chemical cues on macrophages is not well known and there is a complex interplay between biomaterial properties and those that result from interactions with the local environment. Clonal distribution of bone sialoprotein-binding protein gene among Staphylococcus aureus isolates associated with bloodstream infections.

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Radiation protection is ultimately a political process that involves consent by stakeholders, a diverse group that includes people who might be expected to be risk-averse and concerned with plausible upper limits on risk (how bad could it be?), cost-averse and concerned with lower limits on risk (can you prove there is a nontrivial risk at current dose levels?), or combining both points of view. In order to avoid the need for an indwelling catheter, which imposes logistic problems for outpatient administration, several phase II studies have explored the feasibility and efficacy of VAD-like outpatient regimens. Greater certainty of the pathogenesis and progression of the disease will only come with increased years of surveillance. Lipids produced by the epidermis serve a number of protective functions, and also act as messengers which activate plant defense responses. Furthermore, we outline the current techniques for delivering genes of interest with their potential merits and drawbacks in the field of ophthalmology.

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Future research should focus on more specific measures for expectation, and additional behavioural factors, such as self-efficacy, and their effect on employment status. Estimates of genetic parameters associated with lactation feed intake and reproductive performance in purebred and F1 sows. Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects. Given the serious nature of the disease and the ineffectiveness of erythromycin treatment, administration of tetracyclines may be justified, despite the possible adverse fetal effects. Thermal withdrawal latencies in sciatic nerve is prevacid 30 mg over the counter -ligated rats given non-loaded liposomes decreased significantly by day four, with maximal decrease at day seven after surgery, indicating development of full hyperalgesia. The effect of the thio-urethane addition on degree of conversion in depth was dependent on filler type.

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Effect of polymeric materials on the development of experimental mycosis due to Trichophyton rubrum. In the other model, aggregating polyQ proteins partially inhibit the ubiquitin-proteasome system for protein degradation. To evaluate the treatment results of pleomorphic adenoma (PA) of the parapharyngeal space at a single institution during a 30-year period. This increase was small in TA100 but was greater in the GSH-deficient strains. With each of the three methods at least 500 polygraphic sleep recordings were analyzed and the results compared with the outcome of the visual analysis. This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes. A series of selected outpatients were examined who had undergone cataract surgery in the preceding 24 months. Therefore, it is plausible that inhibition of enTNF expression or MnSOD activity in pancreatic carcinoma would improve the efficacy of therapies for pancreatic carcinoma. Guidelines for DOAC/rivaroxaban initiation after VTE are often not adhered to in clinical practice.

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Self-assembly in solution and adsorption at the air-water interface and at solid surfaces were investigated for two amino-acid-based surfactants with conductimetry, NMR, tensiometry, quartz crystal microbalance with monitoring of the dissipation (QCM-D), and surface plasmon resonance (SPR). What is or what would be the most suitable antiretroviral therapy?. Finally, vivo fMRI tests showed that the excited areas evoked by a visual stimuli are mainly in the region of the primary visual cortex and that evoked by auditory stimuli are mainly in the region of the primary temporal cortex. This study demonstrates a statistical correlation between intratumoural differences in neoplastic degree of dedifferentiation and genetic instability in terms of LOH and point mutations of the k-ras gene in colorectal carcinoma. How we can learn from the hotel industry to take better care of patients. The protection by vitamin A appears to result from its effect on the transport of ANIT into bile. Bariatric surgery, on the other hand, has emerged as an effective and safe treatment for obesity and its related comorbidities such as type 2 diabetes.

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The Arabidopsis P450, cytochromes b(5), NADPH-cytochrome P450 reductases, and family 1 glycosyltransferases website (http://www.P450. tricor online is a sequence repository of manually curated sequences, multiple sequence alignments, phylogenetic trees, sequence motif logos, 3D structures, intron-exon maps, and customized BLAST datasets. It is believed that these phenomena could have been due to decomposition occurred during derivatization procedure and/or during GC analysis where the temperatures of certain GC parts were too high. Moreover, wild-type EPEC and the mutant EPEC strain, DeltaespF, had similar effects on barrier function and TJ protein localization at 5 days postinfection. The objective of this study was to develop an acute experimental model showing both focal and macroreentrant sustained atrial fibrillation (AF). The data collection protocol included the Diagnostic Interview for Genetic Studies, the Family Interview for Genetic Studies, a review of medical records, and the collection of blood for transformation into lymphoblast cell lines. Moreover, surface area of the lesion did not correlate with subsequent nodal disease, whereas thickness did. The mucocutaneous junction of the eyelid is located at the posterior border of the free margin and extends to its deep surface. oxysporum known to exhibit inducible kievitone hydratase activity (but not pathogenic to bean) did not have detectable khs homology. The expression of class I transplantation antigens encoded in the major histocompatibility complex (H-2 in mouse, HLA in man) can be induced by alpha-, beta- and gamma-interferons. Reliable assessment of outcome measures for osseous healing, including histology and biomechanical testing, has made preclinical testing of innovative growth factors essential before the advance to clinical trials.

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When dogs are transfused, blood compatibility testing varies widely but may include dog erythrocyte antigen (DEA) 1 typing and rarely cross-matching. In most cases, the mechanism of this is probably a rupture at the site of a vulnerable atherosclerotic plaque, with local activation of coagulation. Forensic evaluation of the sequelae of toxic pulmonary aggressions. Other reactions at different CEC conditions, or subsequent to enzymatical or specific extractive treatments, suggest PPL appearance is due to PHT uptake by clustered anionic phospholipids, which seem to be involved in mineral precipitation. We prospectively enrolled 16 patients on adjuvant treatment with mitotane after radical surgical resection of ACC, who underwent standard hormone evaluation and h-CRH stimulation. Our object was to determine if the aromatic nucleus of estramustine (I) is optimal for binding affinity to prostate cytosolic proteins, and if C3 is the preferred position for the N-mustard carbamate moiety. Pyrosequencing reveals contrasting seasonal dynamics of taxa within Baltic Sea bacterioplankton communities. Data on study design, participants, interventions, and outcomes were extracted from the reports onto specifically designed data collection forms by at least two reviewers. Lingual thyroid is a rare developmental abnormality characterized by the failure of the thyroid gland, or remnants, to descend from its embryologic site of origin at the foramen cecum to its usual pretracheal position. Moreover, different regions of the body will have different functional loads and vascularity.

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