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Afdiex (Glibenclamide)
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Afdiex

Afdiex is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. The usual starting dose of Afdiex as initial therapy is 2.5 to 5 mg by mouth once daily with breakfast or the first main meal.

Other names for this medication:
Afdiex, Aviglen, Benclamet, Benformin, Comdiab, Daocon, Diabnil, Diolin, Duotrol, Dutrol, Giclamide, Glibson, Glifil, Glimsug, Glinil, Glitrac, Glucosil, Glucotrac, Glutowin, Glybenclamide, Glyboral, Glybovin, Glybovine, Melitus, Pionorm, Secrin, Sugatrol, Sugnil, Symet, Triglycomet

Similar Products:
Aurogra, Dilantin, Noroxin, Parlodel, Ambien, Clomid, Sovaldi, Xeloda, Coecoral, Ethidan, Kefnir, Omsat, Nimocer,

Also known as: Glibenclamide

Description

Afdiex is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Afdiex belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Dosage

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Afdiex overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Afdiex dosage information

Side effects

The most common side effects associated with Afdiex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to Afdiex, micronized or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Laboratory, anthropometric, and clinical characteristics were all determined. To report visual acuity (VA) measured by Teller Acuity Cards (TACs) and a new Light Perception/Projection (LPP) Scale in infants with regressed or treated stage 3, 4, or 5 retinopathy of prematurity (ROP), and to compare VA in eyes that underwent successful vitreoretinal surgery for stage 5 ROP with eyes with persistent retinal detachment. Frailty syndrome is associated with altered circulating redox balance and increased markers of oxidative stress. Plant specific GARP transcription factor family (made of ARR-B and G2-like) contains genes with very diverse in planta functions: nutrient sensing, root and shoot development, floral transition, chloroplast development, circadian clock oscillation maintenance, hormonal transport and signaling. Rabbit immune serum of TCP purified from O139 strain agglutinated both O139 biotype and El Tor biotype Vibrio cholera strains. Members of the CCN family of matricellular signaling regulators promote cell adhesion through integrins and heparan sulfate-containing proteoglycans. A modified wet compression method using carboxymethylcellulose sodium (CMC-Na) solution as binder solution was newly developed. A total of 10 094 initially healthy Spanish participants from the SUN Project participated in the study.

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Cytolytic activity of TNF was analysed at L929 and K562 tumor cell lines. The algorithm first performs an automatic segmentation of the eyes on specific reference images. While very few randomized clinical trials have been conducted with prostate cancer patients, recent results suggest that such interventions improve coping skills, increase prostate cancer knowledge, reduce treatment-related disruption of daily activities, diminish bother associated with sexual problems and enhance global quality of life. Medical management of nasal polyposis: a study in a series of 152 consecutive patients. Antitumor immunity in cancer patients is heavily modulated by cells of the innate immune system. In both baboon and monkey sperm, the acrosomal region had the highest intensity stain and the equatorial region had the lowest intensity.

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We used enriched marrow cells from mice administered three doses of 150 mg/kg 5-fluorouracil (5-FU) 1, 3 and 7 days before they were killed to study the effects of different growth factors on the survival of primitive, cell-cycle dormant progenitors in culture. This article reviews the current body of evidence regarding the cardiovascular effects of celecoxib, considered under two distinct, but non-mutually exclusive, headings: cardiorenal and thromboembolic. Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Post-specific fiber diameter, fiber arrangement over the cross-sections and length, and fiber-matrix ratio could be associated with mechanical properties, such as three-point bending strength and structure modulus. Together, our results reveal myeloid cells in the bone marrow as an important source of Wnt10b under complex hormonal and cytokine regulation. A well-known hallmark of GMB and many other tumours is aerobic glycolysis. Levels of a few serum and urinary hormones/metabolites viz., serum testosterone, total triiodothyronine (T3) and thyroxine (T4) and urinary total 17-ketosteroids (17-KS), estrone, estradiol, and 17-hydroxy corticosteroids (17-OHCS) were assessed in alcoholics thrice during the treatment programme at hospital i.e., on the zero (day of admission), 10th, and 20th day and compared to those of non-alcoholic controls. To assess the risk of death associated with work based and non-work based measures of socioeconomic status before and after retirement age.

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Hemodynamic deterioration after cardiopulmonary bypass during pregnancy: resuscitation by postoperative emergency Cesarean section. Final apical shaping is easily achieved when root length is reached. Interviews were analysed using rigorous methods drawn from grounded theory. Biological activity of collagen-bound PDGF was demonstrated by a 1.5-3-fold stimulation of proliferation of human fibroblasts and mouse 3T3 cells. STSG thickness is inconsistent, with a broad spread about a median value.

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Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects. Trends in average weights and heights for men: an insurance experience. Although teenage males were willing to date girls slightly younger than themselves, they indicated a much wider range of acceptability above their own ages, and also reported that their ideally attractive partners would be several years older than themselves. Since then it has been used numerous times in a large variety of settings to extrapolate from finite size systems to the infinite system in a large variety of situations in statistical mechanics. We retrospectively reviewed 107 patients of upper urinary tract carcinoma to determine the overall outcome, prognostic factors, frequency of subsequent bladder cancer and role of adjuvant therapy. The intervention consisted of a two-hour low-GI dietary education session in early pregnancy. This indicates that the mammalian species included in this study probably share only one common ancestor IGHG gene with the horse. The effect of physico-chemical cues on macrophages is not well known and there is a complex interplay between biomaterial properties and those that result from interactions with the local environment. Clonal distribution of bone sialoprotein-binding protein gene among Staphylococcus aureus isolates associated with bloodstream infections.

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Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, pharyngeal and esophageal musculature in 20 healthy individuals and the topography of pharyngeal musculature in two stroke patients, one with and one without dysphagia. Several factors may be involved in antipsychotic-induced body weight gain including the cannabinoid receptor 1 (CB(1)), the serotonin receptor 2C, the ghrelin receptor, neuropeptide Y, adiponectin and proopiomelanocortin. The combined analysis of these three data sets provides a new perspective on the epidemiology of asthma. Management of pancreatic cysts can be guided using novel Markov-based clinical nomograms, and depends on age, cyst size, comorbidities, and whether patients value overall survival vs quality-adjusted survival. Therefore, we carried out a prospective randomized crossover trial comparing treatment with a commercial fibrin glue to classical seton treatment, with healing rate, hospital stay, healing time, faecal incontinence and postoperative pain as study outcomes.

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Cellular events linked to cardiac remodeling in heart failure: targets for pharmacologic intervention. At an 8-year follow-up, the patient was well but with functional sequelae. A non-syndromic bifid tongue with fibrolipoma, ankyloglossia, and clefts of the lower lip and alveolus is rare. Fish production did not differ significantly between hydraulic loading rates. The results indicated that ecological compensation standard from 1999 to 2010 was 40.31-86.48 yuan x m(-2) with the mean of 57.33 yuan x m(-2). Government and senior management have abandoned the communicative function of language, eschewing reasoned debate (as characterized by the use of evidence and structured argument), instead employing language exclusively for the purposes of control and manipulation. The manufacturing process for commercial fibrin sealants comprises a range of procedures, including heat treatment (e.g. Analysis of a polyacrylamide gel electrophoretogram of beagle serum protein by laser densitometer.

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No change was found in the quantity or in the specific activity of bulk RNA labeled with uridine-5-(3)H. If the cervicotomy has been adequate, it is necessary to have a high index of suspicion for a locoregional recurrence and systemic disease, but the indications for reintervention must be respected. In addition, the expression of BiP and CHOP increased in silica-stimulated cells. Additionally, we perform an analysis of the obtained 3D volumes by calculating microstructural characteristics, like porosity, tortuosity and specific surface area. These data indicate that BCMA is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. This is manifested by increased in content of lysophosphatidylcholine (LPCh), phosphatidylserine (PS) and phosphatidyletanolamine (PEA), decreased levels of sphingomyelin (SM) and phosphatidylcholine (PCh). Photon-deficient lesions in the skeleton occasionally are seen in In-111 leukocyte imaging. A series of indolequinones bearing a range of substituents on nitrogen and at the indolylcarbinyl position was prepared by copper(II)-mediated reaction of bromoquinones and enamines, followed by functional group interconversions. Compared with fresh-cut red cabbage, all cooking methods were found to cause significant reduction in anthocyanin and total glucosinolates contents. The widespread bacterial resistance to a broad range of antibiotics necessitates rapid antibiotic susceptibility testing before effective treatment could start in the clinic.

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In this method, the acoustic wave disturbance to the laser probe in the sonochemical reaction field was eliminated by the temporal separation using pulsed sonication (pulsed LD). The failure modes for each fixation technique were also observed and described. To study the feasibility of Leucine-Aspartic Acid-Valine (LDV) as targeting ligand and drug carrier for targeted delivery to integrin alpha(4)beta(1) over-expressing cancer cells. Two families, each with two affected members, were analysed in this retrospective study. Proliferation, cell cycle, and apoptotic assays were performed with ML00253764, whereas the synergism of the simultaneous combination with temozolomide was evaluated by the combination index method. Growth-associated changes in the periodontal bone and molar teeth of male rats. Not all hyperactive children were benefited by the drugs.No background variables (with the exception of mother-child relationship) were found in the present studies to predict favourable response to the drugs.Methylphenidate became our drug of choice for this group of hyperactive children. This maneuver facilitates navigation in supra-aortic vessels from the arch to skull base levels. These included 131 primary cases and 139 secondary cases from the epidemic and 121 vaccinated controls with no history of measles. There is debate whether laparoscopic abdominal surgery results in a lower incidence of adhesional small bowel obstruction (ASBO) compared with the equivalent open procedure.

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Effect of polymeric materials on the development of experimental mycosis due to Trichophyton rubrum. In the other model, aggregating polyQ proteins partially inhibit the ubiquitin-proteasome system for protein degradation. To evaluate the treatment results of pleomorphic adenoma (PA) of the parapharyngeal space at a single institution during a 30-year period. This increase was small in TA100 but was greater in the GSH-deficient strains. With each of the three methods at least 500 polygraphic sleep recordings were analyzed and the results compared with the outcome of the visual analysis. This study describes the identification of the unc-112 gene product, a novel, membrane-associated, intracellular protein that colocalizes with integrin at cell-matrix adhesion complexes. A series of selected outpatients were examined who had undergone cataract surgery in the preceding 24 months. Therefore, it is plausible that inhibition of enTNF expression or MnSOD activity in pancreatic carcinoma would improve the efficacy of therapies for pancreatic carcinoma. Guidelines for DOAC/rivaroxaban initiation after VTE are often not adhered to in clinical practice.

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In addition, we observed an unexpected presence in the cell wall preparations of proteins whose known biochemical activity has never been associated with this compartment hitherto. In normal adult skeletal muscles, IGF-I, IGF-II and developmental fast troponin T mRNA containing exon y, are undetectable or present at very low levels. The fixed dose of 1,400 mg SC rituximab predicted by using stage 1 results was confirmed to have noninferior Ctrough levels relative to IV rituximab 375 mg/m2 dosing during maintenance, with a comparable safety profile. This approach has been found sensitive in a wide range of concentrations, from 15 to 1000 free-AFM(1) ppt with a limit of detection of 12 ppt. The new time of effective planning and complex development based on introduction into the practice of the new forms and methods of control has come. Subsequent addition of phosphines or phosphites in the same pot produces meta-substituted anilines in good yields. Prepartum equine rotavirus vaccination inducing strong specific IgG in mammary secretions. However, being overweight or obese is neither protective nor a risk factor for mortality or duration of mechanical ventilation.

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When dogs are transfused, blood compatibility testing varies widely but may include dog erythrocyte antigen (DEA) 1 typing and rarely cross-matching. In most cases, the mechanism of this is probably a rupture at the site of a vulnerable atherosclerotic plaque, with local activation of coagulation. Forensic evaluation of the sequelae of toxic pulmonary aggressions. Other reactions at different CEC conditions, or subsequent to enzymatical or specific extractive treatments, suggest PPL appearance is due to PHT uptake by clustered anionic phospholipids, which seem to be involved in mineral precipitation. We prospectively enrolled 16 patients on adjuvant treatment with mitotane after radical surgical resection of ACC, who underwent standard hormone evaluation and h-CRH stimulation. Our object was to determine if the aromatic nucleus of estramustine (I) is optimal for binding affinity to prostate cytosolic proteins, and if C3 is the preferred position for the N-mustard carbamate moiety. Pyrosequencing reveals contrasting seasonal dynamics of taxa within Baltic Sea bacterioplankton communities. Data on study design, participants, interventions, and outcomes were extracted from the reports onto specifically designed data collection forms by at least two reviewers. Lingual thyroid is a rare developmental abnormality characterized by the failure of the thyroid gland, or remnants, to descend from its embryologic site of origin at the foramen cecum to its usual pretracheal position. Moreover, different regions of the body will have different functional loads and vascularity.

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