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Alfacal (Calcitriol)

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Alfacal is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones.

Other names for this medication:
Admax, Alfabond, Alfacal, Alfacalcirol, Alfacip, Apcical, Aristrol, Bonestat, Bonetuf, Calbec, Calbory, Calcikind, Calcimet, Calcit, Calcor, Calday, Caldikind, Calfa, Calgel, Calosto, Calotec, Calsonic, Calsure, Calzem, Carcal, Coecoral, Devita, Dmcal, Fovit, Kurecal, Laretol, Lctrol, Minroset, Ostriol, Refirm, Riecal, Ritoca, Rockbon, Rolsical, Solbiocal, Statbone, Sunmic, Tobalt, Vitalpha, Zaxial

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Viramune, Avapro, Cardizem, Cymbalta, Zyprexa, Kastzine, Bimoxan, Pencolin, Anamet, Aldoril, Depsan, Vesdil,

Also known as: Calcitriol


Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.


Generic Alfacal is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacal suddenly.


If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alfacal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Problems in older adults have not been reported with intake of normal daily recommended amounts. Studies have shown that older adults may have lower blood levels of vitamin D than younger adults, especially those who have little exposure to sunlight. Your health care professional may recommend that you take a vitamin supplement that contains vitamin D.

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EFFECT OF WHOLE-BODY X-IRRADIATION ON C-14-LEUCINE INCORPORATION INTO PROTEINS OF CELL NUCLEI OF REGNERATING RAT LIVER. Previous studies from our group demonstrated the synthesis and secretion of alpha 2M in different glial cultures derived from an astrocytoma and a glioblastoma. This study provides the first scyphozoan transcriptome covering the entire developmental trajectory of the life cycle of Aurelia. Defining the amino acid composition of protein cores is fundamental for understanding protein folding, as different architectures might achieve structural stability only in the presence of specific amino acid networks. The obstetrician group is independently associated with the risk of cesarean delivery in nulliparous women, but we could not demonstrate this association with epidural analgesia. Those with gambling problems were less likely to have the expectation that gambling would be fun than those without gambling problems. Submicroscopic changes in skeletal muscle fibers in starvation atrophy.

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On post-SNL day 35, the paw-withdrawal latency values of the young and mature animals returned to presurgical baseline levels, while the aged rats continued to exhibit thermal hyperalgesia. The oscillations are associated with the interference contribution from a special class of electron trajectories confined to the surface of the sample. Such programmes have the potential to improve health outcomes for Pacific and Maori adolescents. Radiofrequency ablation with a multiple-electrode switching system is safe and effective for treatment of RCCs. Ultrasonographic examination revealed a solid and well-defined orbital mass compressing the globe. Such observations could possibly lead to the development of novel non-hormonal contraceptives, improvement of infertility diagnostics and optimization of assisted reproduction. These diverse but interconnected mechanisms are found to be critical in the maintenance of a functional, efficient, and responsive mitochondrial population and could therefore become therapeutic targets in numerous mitochondrion-implicated disorders. This case illustrates that state of the art zirconium oxide CAD/CAM manufactured frameworks with the latest ceramic systems are a user friendly, highly aesthetic alternative to metal-ceramic restorations. The increase in phenotypic variability through gene expression noise is proposed to be an evolutionary strategy in selective environments.

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Interestrous interval of cyclic gilts is decreased by systemic but not intrauterine administration of exogenous oxytocin. The effect of protein kinase C activation on colonic epithelial cellular integrity. Myoelectric Control System and Task-Specific Characteristics Affect Voluntary Use of Simultaneous Control. This is exemplified by summarizing preliminary findings from a large case control study on women below age 65 who were hospitalized with an acute diagnosis of CHD during the past three years in the greater Stockholm area. Scale scores for each domain were correlated with demographics to identify factors associated with training need. Reproducibility of the topographic parameters of the optic disk with the scanning laser tomograph. Classic bonded indirect ceramic or resin composite restorations necessitate at least 2 appointments.

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Letter from the editor: what is the US preventive services task force?. This report describes the evidence for a population-based, province-wide assessment and early management tool that was developed for health care personnel who treat patients with head traumas. In Atlantic salmon with advanced AGD, IL-1beta but not TNF-alpha1 or TNF-alpha2 mRNAs was up-regulated and was lesion-restricted. Moreover, induction of Tat protein after the extinction of CPP produced reinstatement without additional exposure to ethanol. The effects of histamine and related compounds on regional cerebral blood flow (rCBF) in the hippocampus of conscious rats were studied. Histiocytic medullary reticulosis with parallel increases in serum acid phosphatase and disease activity. During implant integration, it may be important to shield the implants from the possible detrimental effects of ionizing radiation. The purpose of this essay is to illustrate the use of sonography in the preoperative examination of patients being considered for the procedure. Mortality analyses were based on the same age-, sex- and deprivation-standardized data that were used in the previous research on the three cities. Subsequent identification and confirmation was carried out with biochemical tests and polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).

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The addition of palmitic acid stimulated growth but was not essential for growth. The concomitant increase in the generation of IL-5 and IFN-gamma, with a decrease in IL-10 in the atopic groups suggests that in, at least a subset of these patients, there is potential expression of both Th2- and Th1-type cytokines. Investigational inhibitors and antagonists of these substances show promise for the future treatment of heart failure. Using the lens of critical race theory, the themes conceived from the analysis were the counterstory of agency, counterstorytelling stereotypes, and the salience of everyday racism. Purification of Pneumocystis carinii trophozoites and identification of their circulating antigens. Seventy patients who underwent short-segment stabilization for thoracolumbar (T11-L2) burst fractures in our clinic between 2008 and 2012 were included in this retrospective study. In addition, frequency of failure to meet a response time goal of less than 20 seconds was significantly higher in the 48-patient condition than in all other conditions. Bakuchiol, a meroterpene isolated from Psoralea corylifolia, prevented mitochondrial lipid peroxidation. Overview of tropical endoparasitic diseases with cutaneous manifestations. This procedure we carried out in 41 cases and did not see any postoperative complications yet.

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The impact of polymorphisms in metabolizing enzymes (thiopurine S-methyltransferase, dihydropyrimidine dehydrogenase, and uridine diphosphate glucuronosyltransferase) that participate significantly in the disposition of these anticancer agents is discussed. Thus, the innate fungicidal activity of primary human AM is impaired after HIV-1 infection in vitro by a mechanism involving a defect of intracellular antimicrobial processing. Based on homology of the gene product to various peptidases and on the substrate specificity determined, the peptidase was designated PepQ. Our study therefore provides compelling evidence that TRPM2 has a unique role in breast adenocarcinoma cells. Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis. Adaptation of a simple instrument for measurement of the true conjugate. Is most prevalent in cases with odditis, gallstone impactation and ampulloma. Inflammation is a recognized antecedent and coincident factor when examining the biology of anxiety. Effect of estrogen on cerebral glucose metabolism in postmenopausal women. These data demonstrate that a currently available and well-tolerated inhibitor of NF-kappaB can decrease the risk of myocardial injury associated with ischemia-reperfusion.

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We show that germline mutations in human MIB1 (mindbomb homolog 1), which encodes an E3 ubiquitin ligase that promotes endocytosis of the NOTCH ligands DELTA and JAGGED, cause LVNC in autosomal-dominant pedigrees, with affected individuals showing reduced NOTCH1 activity and reduced expression of target genes. Therefore, it is important to develop agents that overcome this resistance. On the mechanism of protein binding of the carcinogen N-2-fluorenylacetamide by rat liver. Workplace interventions to reduce HIV and TB stigma among health care workers - Where do we go from here?. Commentary: Race and mental health--more questions than answers. These studies suggest that the concentration of DHT in prostatic tissue is dependent on the level of NADPH necessary for the 3 alpha-HSORred and 3 beta-HSORred enzymes to convert DHT to its respective diols. The tumorigenicity of ISL-treated cells was limited significantly by using the colony formation assay in vitro and an animal model assay in vivo respectively. QRS wave amplitude significantly increased in leads V2 through V5 during narrow QRS tachycardia compared with QRS waves in sinus rhythm. The present measurements in the same individuals showed that there is no difference in the number of vasoactive intestinal polypeptide (VIP)-expressing neurons in the SCN.

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Inhibition of hypothalamic GnRH secretion in the ewe by antigonadotropic decapeptide during the estrous cycle and nonbreeding season. The story of the developmental changes in erythropoiesis is the history of oxygenation in the developing organism. Of particular importance is the strength of interactions between the carrier and the ON, which determines the rate at which the ONs are delivered intracellularly. Insights via ion-molecule reactions of N-acylpyridinium ions and ab initio calculations. FD was an effective indicator reflecting the EEG complexity and zDFD was useful to reflect the variability of the EEG complexity. It is argued that polar expeditions of an earlier age are a better model for space exploration than confinement studies or Antarctic overwintering. Effect of overexpressing Nisin A structural gene nisA on Nisin A production. FDG-PET is a very useful technique for differentiating benign from malignant disease. 7 cleft is a lateral facial cleft which originates from the oral cavity and extends towards the tragus, involving both soft-tissue and skeletal components.

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On the factors controlling the reversibility of DNA denaturation. The first symptoms of nicotine dependence can appear within days to weeks of the onset of occasional use, often before the onset of daily smoking. These findings underscore the need to improve access to MMTP, especially to certain subgroups such as African-Americans, the homeless, incarcerated and uninsured. The purpose of the current study was to replicate this association in the Old Order Amish. Molecular basis of disorders of human galactose metabolism: past, present, and future. Serum levels of heat shock protein 27 in patients with acute ischemic stroke. Red globules, white globules and plaelets were isolated from blood collected using these two different recovery systems and analysed by SEM. Other observed features were determined by alterations in sympathetic and parasympathetic nervous system tonus.

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Amyloid in human islets of Langerhans: immunologic evidence that islet amyloid polypeptide is modified in amyloidogenesis. Tissue transplantation is an important adjunct to modern medical care and is used daily to save or improve patient lives. The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200 different proteins and five small nuclear RNAs (snRNAs). A new glycosyl donor possessing an anomeric O-(1-phenyltetrazol-5-yl) group is prepared from 2,3,4,6-tetra-O-benzyl-D-glucose (2) and commercially available 5-chloro-1-phenyl-1H-tetrazole (1). Three fractionated X-ray schedules were used, with and without the electron-affinic radiosensitizer of hypoxic cells, Ro-07-0582, to determine the local control of first-generation transplants of spontaneous mammary tumours in C3H mice. Development of an electrochemical ELISA for the screening of 17 beta-estradiol and application to bovine serum. Most of the patients demonstrated contact between the LA occluder disk and the aorta throughout the cardiac cycle. We studied the blood coagulation system of 14 patients with metastatic malignancies before and after they had undergone major surgery.

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To evaluate the feasibility of visualization and balloon dilatation of the protympanic segment of the eustachian tube during chronic ear surgery. The present studies used selected lines of mice to assess genetic correlations among ethanol drinking, ethanol locomotor sensitization, and tolerance to the depressant effects of ethanol. Isolated ecosystems would display posttreatment insect recovery dynamics very different from highly connected ones, evolving toward alternate pseudoequilibrium states, possibly with lower biodiversity but with preserved functionality. Several breakthroughs in GPCRs biased pharmacology, structural biology, modelling and scoring have resulted in a resurgence of interest in GPCRs as drug targets. To determine if fenofibrate accelerates the development of heart failure in large mammals, we have tested its effects on the progression of left ventricular dysfunction in pacing-induced heart failure in pigs. These observations suggest that the TLR9 promoter polymorphism C-1237T might affect AE susceptibility in particular in patients with the intrinsic variant of AE. The value of combining multiple screwed plates in humeral shaft fractures. Scaling the intrinsic clearance values for the individual CYP enzymes to estimate contributions of each in human liver microsomes suggested that CYP2D6, CYP2C9, and CYP3A4 contribute the greatest amount of fluoxetine N-demethylation in human liver microsomes.

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Ecological variation in essential elements and trace elemental composition of some Nigerian fruits. Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. Because skin lesions and scintigraphic enhancement of the sternoclavicular joints with hyperostosis were present, a SAPHO syndrome was diagnosed in both sisters. Renal lymphoma is most often seen in conjunction with multisystemic, disseminated lymphoma or as tumor recurrence. However, fat, tumor, and air may all embolize to the pulmonary vasculature and lymphatics resulting in various clinical manifestations. Electrostatic potential distribution of the gene V protein from Ff phage facilitates cooperative DNA binding: a model of the GVP-ssDNA complex. Insulin-like growth factor binding protein (IGFBP)-3-bound IGF-I and IGFBP-3-bound IGF-II in growth hormone deficiency. Hospitals could have qualified professionals offer reflexology as a complementary therapy and teach interested partners the modality.

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Various assumptions and physiological interpretations of the different approaches to the biokinetic modelling of the skeleton are discussed. Thus, in human DC LPS stimulates a signal cascade that involves the Raf-dependent activation of RIP2 leading to expression of IL-12 p40. Ectopic expression of the hrpRS gene operon restored gene expression, but not protein secretion, in the hrpA mutant. The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein. In the case of a model complex fluid (a triblock copolymer solution), we demonstrate that such a steady gradient crosses the phase diagram from pure water up to a succession of highly viscous mesophases.

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Meiotic maturation of mouse oocytes in vitro: association of newly synthesized proteins with condensing chromosomes. In generic brand of prilosec this investigation, acoustic radiation force was used as a stimulus to determine the threshold for tactile perception in the human finger and upper forearm as a function of frequency and pulse duration. All these risk factors should be avoided in tibial nailing to decrease the problem of postoperative knee pain. A wide range of implications follow regarding formulation and future developments, both for dispersed LLC delivery systems and topical applications in bulk phase. Hepatitis C virus (HCV) is the major causative agent of blood-borne hepatitis. Targeting was mediated through the use of an antibody specific for the Thy 1.2 antigen that is highly expressed on P388 cells. In patients with OSA being treated with CPAP, the prevalence of GER and nighttime GER symptoms is greater in those with symptoms of aerophagia than those without. These constructs might be used for in vivo intramuscular delivery of plasmid DNA and as a set of reagents for the development of retroviral as well as adeno-associated viral (AAV) vectors expressing angiogenesis inhibitors.

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Understanding how all these factors are organized in the chromosome and how their function is regulated in vivo is a challenging task. Exercise-induced changes in the concentration of individual fatty acids and triacylglycerols of human plasma. An ARMS assay of the A/T base change at the -23/HphI RFLP in the insulin gene promoter, which initiates from 2.5 ng template DNA, was used here to demonstrate this improved general approach for population SNP analyses. Cardiopulmonary rehabilitation in a patient with Noonan syndrome. STUDIES OF THE FORMATION OF RIBONUCLEIC ACID AND PROTEINS IN INSECTS. Hormone therapy and risk of venous thromboembolism among postmenopausal women in Taiwan - a 10-year nationwide population-based study. Considerations on otopathies found in agricultural workers in Puglia.

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In two complementary experiments, we studied the effects of low frequency stimulation (LFS) of the amygdala on behavioral effects of kindling in rats and cats. The presence of circulating non-organ specific autoantibodies is not a characteristic feature in Takayasu Arteritis when strict diagnostic criteria are applied. Balance capabilities were measured with the Functional Reach Test (FRT) and the Tinetti Performance-Oriented Mobility Assessment (POMA). The rapid assay offers the following major advantages: (i) it provides results within 4 to 6 days, (ii) it can be performed with peripheral blood leukocytes, and (iii) it reliably detects drug-resistant human cytomegalovirus strains. These data indicate that coelomocytes are capable of producing and releasing NO and that NO is a chemical mediator that has been conserved as a host defense weapon of phagocytes through evolutionary time. Efficacy of treatment was evaluated by determining changes in skin reactivity, visual analog scores, diary symptom scores and end of study assessments.

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The response of the thyroid gland to thyrotrophic hormone before and after hypophysectomy in patients with metastasizing mammary carcinoma. A neutral wedge in the combined exchange beam (but not in the steady background that covered the whole receptive field) regulated the size of the exchange stimulus and thus the magnitude of the ganglion-cell discharge heard from a loud speaker to the exchange. The HTLV-1 in vivo mutation rate is comparable to that of bovine leukemia virus (BLV), another member of the HTLV/BLV genus of retroviruses, and is about fourfold lower than that of HIV-1. Eleven patients were women, of whom 6 had breast cancer, 3 had osteoporosis, and 2 had multiple myeloma. The results were analyzed by the multivariable regression remeron medication sleep method. 17 with severe, 22 with moderate, and 15 with mild disease, as well as 18 controls were recruited. Compared to control subjects, TLE patients exhibited increased RMT in motor cortex and higher PPI ratios for auditory P50m and somatosensory P35m responses. aeruginosa in accordance with DIN EN 12780 in monitoring pool water of small bathing facilities.

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These results identify a synapse-associated E3 ubiquitin ligase as an important regulator of MuSK signaling. The positions of labeled neurons in SI and the surrounding cortical areas were plotted on flattened surface reconstructions to determine the organization of the corticocortical connections within SI. Reconstructions from trigonometric and pairwise current injection patterns are included. Cardiac-specific Bmi1 deletion induces the development of DCM, which progresses to lung congestion and heart failure. Vulnerability to unhealthy behaviours across different antabuse medication liver age groups in Swedish Adolescents: a cross-sectional study. Free fatty acid content of adipose tissuein three types of obese mice during fasting. Thirty-five healthy volunteers (20 young and 15 elderly) participated in this study.

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