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Allopurinol

Allopurinol is the first choice medication to prevent gout flares. Allopurinol stops an enzyme called xanthine oxidase from making uric acid; this then lowers the uric acid levels in your body. Keeping uric acid levels low can prevent gout attacks and kidney stones.

Other names for this medication:
Algoric, Allgoric, Allopurinol, Alloric, Alopur, Aloric, Aloriv, Alpuric, Axanthine, Biorinol, Ciploric, Estinol, Gudloric, Kayloric, Klorinol, Lodiric, Mallor, Mecnol, Myloric, Purinol, Purolic, Riloric, Satric, Seloric, Swiloric, Ureka, Uriclear, Uridip, Urigon, Urinol, Uripure, Xoric, Zanupirol, Zeric, Zyloric, Zyprinol, Zyrinol, Zytol

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Description

Allopurinol is used to prevent or lower high uric acid levels in the blood. It is also used to prevent or lower excess uric acid levels caused by cancer medicines or in patients with kidney stones. A high uric acid level can cause gout or gouty arthritis (joint pain and inflammation). Allopurinol is a xanthine oxidase inhibitor that works by decreasing the uric acid produced by the body.

This medicine is available only with your doctor's prescription.

Dosage

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

You may take this medicine after meals to avoid stomach upset.

Take this medicine with plenty of liquids to help prevent kidney stones. Check with your doctor about the amount of liquid you should drink each day. You should also increase your fiber intake.

You may need to lessen your intake of animal protein, sodium, refined sugars, or foods rich in oxalate and calcium, especially if you have kidney stones that keep coming back.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For gout: Adults—At first, 100 to 300 milligrams (mg) per day, taken once a day or in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 800 mg per day. Children—Use and dose must be determined by your doctor. For high uric acid levels caused by cancer medicines: Adults and children 11 years of age and older—600 to 800 milligrams (mg) per day, taken in divided doses for 2 to 3 days. Children 6 to 10 years of age—300 mg per day, taken once a day for 2 to 3 days. Children younger than 6 years of age—150 mg per day, taken once a day for 2 to 3 days. For kidney stones: Adults—200 to 300 milligrams (mg) per day, taken once a day or in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 800 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Allopurinol and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from light and moisture. Do not store in the bathroom. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Allopurinol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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A review of its pharmacology and therapeutic efficacy in angina pectoris. The internalized caveolin-1 was colocalized with the endocytosed transferrin in the Rab5-, Rab4- or early endosome antigen-1-labeled compartment where caveolin-1 was phosphorylated. Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands. To evaluate the role of the combination of endorectal coil and external multicoil array magnetic resonance imaging (MRI) in the management of prostate cancer and predicting the surgical margin status in a single-surgeon practice. Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human.

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Normal tissues and tumors from the various sites were all negative for HSD3B1 except for 2 adrenocortical adenomas with weak focal immunoreactivity. Perineal hernias are uncommon complications after open abdominoperineal resection. This study aimed to identify the preoperative predictors of microvascular invasion (MVI) in solitary small hepatocellular carcinoma (HCC) and evaluate their application in surgical treatment. Two unilateral cryptorchid stallions were referred to the clinic because of chronic debilitating condition with emaciation. Respondents comprised 24 bureaucrats from the Victorian Department of Human Services (DHS) and 26 senior executives from the aboriginal community controlled health sector (ACCHS) in Victoria. Thus, we demonstrate the existence of modulators, positively controlled by Spo0A, which inhibit inappropriate entry into the costly process of sporulation, when conditions are favorable for exponential growth. Her disease was considered to have entered the central nervous anafranil medication information system, one of the target organs of visceral larva migrans. Results showed STAR-Math in all 3 grades and AIMSweb Math Concepts/Applications in the third and fifth grades had primarily linear growth patterns in mathematics. Employing a kinetic Monte-Carlo method with natural time scales allows us to go beyond the assumptions of small driving field amplitudes and negligible inter-particle interactions, which are fundamental to the applicability of the standard approach based on linear response theory. Little or no CO2 was formed from the disaccharide in flooded soil or anaerobic sewage.

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One Myc-collaborating and p53-suppressing gene, Jdp2, was derepressed in an Hdac1/2-dependent manner and critical for the survival of Jdp2-overexpressing lymphoma cells. Phoniatric interpretation of evaluation principles in professional voice disorders. A unique population of deposits was present in the hippocampus and prefrontal cortex, whereas in the globus pallidus two main groups could be differentiated. Both contained the unusual feature of a 3,4 seco-glycopyranosyl moiety. EtOH also blocked N-methyl-d-aspartic acid-induced LHRH release, but the blockade could not be reversed by either the GABA receptor blocker, bicuculline (10(-5) M), naltroxone (10(-8) M), or both inhibitors added together. Efficacy of influenza vaccine in the elderly: reduction in risks of mortality and morbidity during an influenza A (H3N2) epidemic for the elderly in nursing homes. After undergoing methanol inducible expression for 96h, the wet cell weight of Pichia, the lipase activity and the protein content in the fermentation broth reached their highest values of 262g/L, 38,500U/mL and 2.82g/L, respectively. No established chemotherapy or radiation therapy treatments are currently available for recurrent or advanced carcinoid tumors.

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There is virtually no reaction between native DNA and bisulfite. Electrophysiological and morphological properties of a direct projection from the nucleus of the tractus solitarius (NTS) to the ventrolateral medulla (VLM) were investigated. Dominant-inhibitory mutations of the type II and type I TGF beta receptor. Co-incubation with diazepam, GABA, BAPTA-AM, vitamin E, SP600125 and cyclosporine A significantly reduced cell death. Pediatric HIV infection in a tertiary care center in North India: early impressions. The complex transcriptional landscape of the anucleate human platelet.

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It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results. Early direct and transneuronal effects in mice with targeted expression of a toxin gene to D1 dopamine receptor neurons. This results in a delay in diagnosis and in inappropriate therapy. A 91-item food frequency questionnaire, including data on yogurt consumption, was administered to 664 subjects from the INFOGENE study. Twelve subjects took part in a study of the use of adhesively bonded all-porcelain restorations in the management of worn and fractured anterior teeth. Gluing the capsule to a supporting block is useful for reorientation of the capsule but otherwise time consuming. The incidence of major bleeding complications is also somewhat higher in PV and ET than in the general population. Clerkship evaluation by students: a standardized electronic mechanism. The purpose of this study was to determine ECD SPECT scan patterns of healthy adults. Specific MRE findings may help to stratify treatment options, however, further work is required to validate this.

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