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Alpam (Alprazolam)

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Alpam is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aaram, Alcalm, Alcicalm, Alpram, Alprasert, Alprazan, Alprose, Alprosym, Alzoax, Alzopam, Anxico, Anxigon, Axizox, Azicalm, Azoslip, Coolam, Depflu, Depsolam, Fluxozam, Fluzolam, Fultop, Imprax, Jolistar, Nitril, Notens, Pizolam, Prolam, Proprazolam, Resolin, Resta, Resto, Samprex, Selamb, Setlan, Sinozol, Somaspas, Stresnil, Tensyn, Trapose, Xycalm, Xylonite, Zeprax, Zocam, Zolent, Zolipax

Similar Products:
Geodon, Cleocin, Estrace, Glyburide, Valtrex, Phenergan, Lunesta, Daklinza, Lexapro, Ilosone, Ramadol, Clozine, Lakpam, Armix, Certiwon, Dipwell, Prodroxy,

Also known as: Alprazolam


Alpam XR (alprazolam) is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Alprazolam affects chemicals in the brain that may become unbalanced and cause anxiety.

Alpam XR is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

Alpam XR may also be used for other purposes not listed in this medication guide.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

Measure the liquid form of Alpam with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not swallow the orally disintegrating tablets whole. Allow it to dissolve in your mouth without chewing.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

You may have seizures or withdrawal symptoms when you stop using Alpam. Ask your doctor how to avoid withdrawal symptoms when you stop using Alpam.

Keep track of the amount of medicine used from each new bottle. Alpam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alpam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpam dosage information

Side effects

The most common side effects associated with Alpam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Alpam XR if you have:

narrow-angle glaucoma; if you are also taking itraconazole (Sporanox) or ketoconazole (Nizoral); or if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking Alpam XR, tell your doctor if you are allergic to any drugs, or if you have:

asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems; glaucoma; kidney or liver disease (especially alcoholic liver disease); a history of depression or suicidal thoughts or behavior; or a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

It is dangerous to try and purchase Alpam XR on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of alprazolam purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit

FDA pregnancy category D. Alpam XR can cause birth defects in an unborn baby. Do not use Alpam XR without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Alprazolam can pass into breast milk and may harm a nursing baby. Do not use Alpam XR without telling your doctor if you are breast-feeding a baby.

The sedative effects of Alpam XR may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Alpam XR. Do not give this medication to anyone under 18 years old.

Alpam XR pregnancy and breastfeeding warnings (more detail)

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A resonator sensor for measurement of intraocular pressure--evaluation in an in vitro pig-eye model. These results provide in vivo evidence that the extent of smooth muscle cell proliferation and neointima formation following endothelial denuding injury is not affected by the absence of TSP-1. Income tax questions of doctors in view of financial legal terminology. Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88. A long-term use analgesic with a good benefit/risk ratio is advantageous. Service priorities and unmet service needs among people living with HIV/AIDS: results from a nationwide interview of HIV/AIDS housing organizations. Within this protocol, we present a strategy for isolation of large numbers of inflammatory neutrophils and macrophages from murine skin that allows for follow-up in vivo or in vitro studies. Trypsin-chymotrypsin-ribonuclease association in gynecological inflammations. Comparisons of the low resolution structure of several small RNA-containing viruses. Three ports placed in the linea alba of the abdomen (three-midline-ports technique): an alternative approach for laparoscopic cholecystectomy.

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A Lotus japonicus Cochaperone Protein Interacts With the Ubiquitin-Like Domain Protein CIP73 and Plays a Negative Regulatory Role in Nodulation. In contrast, in extracellular parasites, degenerate repetitive motifs are enriched in proteins that are likely to play roles in evading host immune response. High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis. gamma-HCH was utilized as sole source of carbon and energy, and the degradation proceeds by successive dechlorination. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-ASMMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. Apropos of various types of biliary peritonitis without perforation. Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients. The specimens were fractured in a bending-torsion loading pattern with concurrent monitoring by two AE sensors. Pulse-administration of vinblastine followed by continuous administration of ketoconazole warrants investigation in the treatment of hormone-independent metastatic prostate cancer. An improved synthesis of functionalized biphenyl-based phosphine ligands.

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HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations. Our analysis reveals that the two-scale structure of the lotus leaf surfaces is necessary for keeping both the structure and the superhydrophobicity stable. SotA is a member of the sugar efflux transporter family, while SotB belongs to the multidrug efflux family. The possible cause was that during placement or thereafter during positioning, the endotracheal tube was malposed or slipped upward, rendering its inflated cuff to rest against the vocal cords. The effects of depriving feed to facilitate transport and slaughter in sheep--a case study of cull ewes held off pasture for different periods. The role of the routinely not cultivated bacteria in healthy and diseased subjects needs to be established. Role of injury and hyperplasia in the induction of hepatocellular carcinoma. Detection of fetal trisomy 18 and 13 has been reported as well but seems to be less accurate with the use of this approach. The nature of the genistein-sensitive kinases required for polarization and long-term patterning is discussed in light of these data.

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We used the estimated costs and risk prevalence rates to create a composite Workforce Wellness Index (WWI) score. Previous studies have demonstrated that isoflurane can provide both neuroprotection and neurotoxicity in various tissue culture models and in rodent developing brains. Gene expression relevant to Down syndrome: problems and approaches. During the UV-initiated polymerization, the fiberglass bundles were embedded in the PMMA substrate to form fiberglass-packed microchannels. The macrophage - a novel system to deliver gene therapy to pathological hypoxia.

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Analyzing the ingredients of a telephone counseling intervention for traumatic brain injury. We have developed a new technique for treatment of intramucosal carcinoma which exceeds the standard indication benicar generic hct for endoscopic mucosal resection and carcinoma invading the submucosa without lymph node metastasis that are located in the posterior wall of the stomach, which we refer to as laparoscopic intragastric full-thickness excision (LIFE) under flexible endoscopic control. Occurrence and structure-function relationship of pentameric short sequence repeats in microbial genomes. However, there was a marked decrease in the in vitro phosphorylation of FAP in the immunoprecipitates from Fc epsilon RI aggregated cells. The product was detected by a biotin-streptavidin system using the biotinylated plant lectin Sambucus nigra agglutinin (SNA), which binds to sialic acid in alpha-2,6, but not in alpha-2,3, linkage.

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During 1985-1990, two groups of killer whales in Prince William Sound, Alaska, experienced unusually high rates of mortality, while seven others did not. Two patients had multiple previous operations that failed, first with autogenous vein and later with fabric grafts. These cell lines were human papillomavirus (HPV)-positive and carried wild-type p53. The key for predicting and preventing DILI is to understand the underlying mechanisms. Alcohol drinking is a major etiological factor of oro-esophageal squamous cell carcinoma (OESCC). Fumonisin B1 inhibited the synthesis of the inositol-containing sphingolipids inositol phosphorylceramide, mannosylinositol phosphorylceramide, and mannosyldiinositol phosphorylceramide. He was treated successfully with chloroquine (1500 mg over 3 day period) and primaquine (15 mg/day for 14 days beginning day 4). A dose-dependent increase in the state of phosphorylation of DARPP-32 occurred in mouse striatum after systemic administration of the D(2) receptor antagonist eticlopride (0.1-2.0 mg/kg). We also discovered that one of the domains is important for the folding of the other.

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Central diabetes insipidus in pediatric severe traumatic brain injury. Data presented in this report are estimates based on a sample of nursing home facilities, residents, and discharges from the 1997 National Nursing Home Survey (NHHS). There was no stromal haze in any eye after the epithelium healed. Efforts to characterize the memory system that supports sentence comprehension have historically drawn extensively on short-term memory as a source of mechanisms that might apply to sentences. A dynamic programming method for determining the optimal segmentation into a given number of segments is provided. Applying concepts of species read-across, mammalian pharmacokinetic data were used to systematically prioritize APIs by estimating their potential to cause adverse biological consequences to aquatic organisms, using fish as an example. It reports the improvements of perfusion setup according to Langendorff introduced by the authors. Inserts bearing the coding sequences of NPT II and beta-glucuronidase (GUS) were placed between the nuclear inclusion b (NIb) and coat protein (CP) domains of the wheat streak mosaic virus (WSMV) polyprotein ORF. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. There was 1 case of postoperative small bowel obstruction and no wound infection or incisional herniation.

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The diagnostic accuracy of fine needle aspiration cytology (FNAC) of salivary lesions is relatively high, but cytologic interpretation might be confusing if the sample is lacking typical cytologic features. Treatment of rats with (6)-shogaol, at a dose of 160 mg/kg but not at 80 mg/kg, for 20 min significantly decreased release of immunoreactive substance P, evoked by capsaicin (10 microM), from the slices of cord. Charge-transfer chromatographic study of the complex formation of some anticancer drugs with gamma-cyclodextrin. Colorectal cancer (CRC) is the most common type of cancer in the world. This finding is consistent across international healthcare institutions and supports efforts to disseminate laparoscopic skills. Ethanol concentration in inhaled breath was measured using Gilian pump LFS-113. Our results suggest zyrtec 10 mg on dailymed that although antioxidant enzyme activities were down-regulated in rheumatoid patients, we can decrease ROS generation by macrophages via inhibition thioredoxin reductase by goldthioglucose. Indeed, silencing of Ephrin B3 using siRNA in NSCLC cells resulted in a major alteration of their morphology with an elongated phenotype, decreased proliferation and increased cell death signaling. Establishment and characterization of an Oklahoma isolate of Anaplasma marginale in cultured Ixodes scapularis cells.

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Experimental studies of the local and general effects of SO-2 administered through the respiratory tract. Transtendinous pinning is a new, undescribed technique that is useful in the treatment of such specific injuries. Contribution to the study of factors affecting stem cells of hematopoiesis in spleens of irradiated mice. Our findings also indicated that down-regulation of the PKC activity might be involved in the ceramide-induced apoptosis in cultured granulosa cells. Emotional functions in transsexuals after the first step in physical transformation. Perceived ability to manage juvenile chronic arthritis among adolescents and parents: development of a questionnaire to assess medical issues, exercise, pain, and social support. Power-law modeling based on least-squares criteria: consequences for system analysis and simulation. Additionally, flow cytometry monitored platelet degranulation (P-selectin or CD63), as well as surface-bound fibrinogen, von Willebrand factor and factor XIIIa.

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