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Antram (Tramadol)

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Antram is used to help relieve moderate to moderately severe pain. Antram is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Adamon, Anatram, Antram, Arodol, Avdol, Cemadol, Dolstar, Domadol, Eltram, Hyperdol, Ibudol, Nobligan, Nopidol, Omodol, Opidol, Oshdol, Pacadon, Relidol, Rybix, Sayodol, Servodol, Siatram, Spasteez, Standol, Tacil, Taxidol, Tramagesic, Tramared, Tramataur, Trambax, Tramest, Tramol, Trampar, Tranat, Trandol, Trasic, Tromar, Tromfil, Trydol, Tryme, Ubitdol, Ultraspas, Veeradol, Vegadol, Victadol, Xidol, Zamadol, Zytram

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Also known as: Tramadol


Antram (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Antram is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Antram ER) is for around-the-clock treatment of pain. Antram ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Antram: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Antram is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Antram dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Antram are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Antram ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Antram ER should not be given to a child younger than 12 years old. Antram ER should not be given to anyone younger than 18 years old.

Do not give Antram ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Antram ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Antram ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Antram ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Syntheses of 2-keto-3-deoxy-D-xylonate and 2-keto-3-deoxy-L-arabinonate as stereochemical probes for demonstrating the metabolic promiscuity of Sulfolobus solfataricus towards D-xylose and L-arabinose. Genecentric also has an extension, GenecentricGO, to query FuncAssociate (Bioinformatics 25:3043-3044, 2009) to retrieve GO enrichment statistics on generated BPMs. From the investigation of public health practices, the tensions produced by this concept are analyzed, giving visibility to those practices that demonstrate the public health experience as a force in the world of health. The production of beta lactamases is an important mechanism through which bacteria become resistant to antibiotics. Thus, illness related characteristics especially are associated with sad mood after remission. Alternatively, phase separation of OAz and/or formation of grain boundaries might affect SC permeability, hereby increasing Hg penetration. The mechanisms of lymphocyte induced toxicity remain to be explained. However this strain, and especially GAPDH overproduction is sensitive to glucose availability.

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Hyphal walls of isolated lichen fungi: autoradiographic localization of precursor incorporation and binding of fluorescein-conjugated lectins. Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition. This paper describes a delegated system developed for the South East Thames Regional Health Authority and now being introduced within the Eastern Sector of the South Thames Regional Health Authority. This first report on expression of all major CYPs in hepatocyte-like cells derived from hESC represents an important step towards functional hepatocytes, but efforts to further differentiate the cells using optimized protocols are needed before they exhibit similar levels of drug metabolizing enzymes as primary human hepatocytes and liver. Although the pivotal role of monocytes in immune regulation by their production of proinflammatory and inhibitory cytokines is acknowledged, limited information is available on monocyte changes in aging. To use computational fluid dynamics (CFD) technology to help providers understand (1) how septal perforations may alter nasal physiology and (2) how these alterations are influenced by perforation size and location. A total of 354 men affected by idiopathic oligozoospermia from three medical centres. Severe autoimmune type V hyperlipidemia preceding a systemic lupus erythematosus in a 15 year-old girl. At present, three classes of eukaryotic sugar transporters have been characterized, namely the glucose transporters (GLUTs), sodium-glucose symporters (SGLTs), and SWEETs.

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High-resolution nuclear magnetic resonance spectroscopy has been used to demonstrate the feasibility of determining iodine value and average molecular weight of oil in individual corn kernels. Insights from semantic dementia on the relationship between episodic and semantic memory. Adjustment for risk factors did not alter the significance of the association between increased heart rate and mortality from noncardiovascular causes. Our experimental setup considers a situation in which all joints above the ankle are braced, and stabilising torque at the ankle is generated by stimulation of the plantarflexors. Responsibility due to medication errors in France: a study based on SHAM insurance data. However, the emergence of activity is much slower than the conversion of the single-chain zymogen to a two-chain intermediate. This suggests that the antimycin A-sensitive generation of superoxides originates primarily from the Q(o) semiubiquinone. We evaluated the frequency of primary neural cell embryonal tumors and gliomas in a large international data set. Lidocaine metabolism to monoethylglycinexylidide is also a valid tool to assess liver function. The arthropod-borne Toscana virus is a common cause of acute neurological infection in the Mediterranean basin.

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The study was based at a large organization delivering services for children and adults with autism. SCALES FOR MEASURING COMPULSION, HOSTILITY, NEUROTICISM, AND SHYNESS. The level of beta-galactosidase activity was up to 2.5-fold lower when MG5267 cells, which contain a chromosomal copy of the lactose operon, were grown in glucose compared to those grown in lactose. A genome-wide association study of early menopause and the combined impact of identified variants. Actions of a cholinergic antagonist on mammalian skeletal muscle. Best results were obtained when hTfR was dissolved with octylpolyoxyethylene, mixed with detergent-solubilized soy bean lecithin, and reconstituted by slow dialysis. Repair replication, unscheduled DNA synthesis, and the repair of mammalian DNA.

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