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Anxilor (Lorazepam)
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Anxilor

Anxilor, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Anxilor tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of Anxilor. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Lopam, Loracalm, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Trapex, Urpam, Zepatrac, Zepnap

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Cordarone, Biaxin, Catapres, Acticin, Lozol, Exelon, Aptogrel, Azithrex, Norcozine, Zolipax, Foxidom, Lancid, Ambulax,

Also known as: Lorazepam

Description

Anxilor belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Anxilor are categorized based on how fast they work. Anxilor is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.

Dosage

When given intramuscularly, Anxilor Injection, undiluted, should be injected deep in the muscle mass.

Injectable Anxilor can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Anxilor Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Anxilor Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lorazepam can be fatal if you take it with alcohol, opioid medicine, or other drugs that cause drowsiness or slow your breathing.

Overdose symptoms may include extreme drowsiness, confusion, slurred speech, feeling restless, muscle weakness, loss of balance or coordination, feeling light-headed, slow heartbeats, weak or shallow breathing, or coma.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Anxilor is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Anxilor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anxilor should be avoided in people with:

Allergy or hypersensitivity – Past hypersensitivity or allergy to Anxilor, to any benzodiazepine, or to any of the ingredients in Anxilor tablets or injections

Severe respiratory failure – Benzodiazepines, including Anxilor, may depress central nervous system respiratory drive and are contraindicated in severe respiratory failure. An example would be the inappropriate use to relieve anxiety associated with acute severe asthma. The anxiolytic effects may also be detrimental to a patient's willingness and ability to fight for breath. However, if mechanical ventilation becomes necessary, Anxilor may be used to facilitate deep sedation.

Acute intoxication – Anxilor may interact synergistically with the effects of alcohol, narcotics, or other psychoactive substances. It should, therefore, not be administered to a drunk or intoxicated person.

Ataxia – This is a neurological clinical sign, consisting of unsteady and clumsy motion of the limbs and torso, due to failure of gross muscle movement coordination, most evident on standing and walking. It is the classic way in which acute alcohol intoxication may affect a person. Benzodiazepines should not be administered to already-ataxic patients.

Acute narrow-angle glaucoma – Anxilor has pupil-dilating effects, which may further interfere with the drainage of aqueous humor from the anterior chamber of the eye, thus worsening narrow-angle glaucoma.

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This article provides an overview of some emerging research issues on population and development, appropriate program design, the impact of family planning programs, and a tentative agenda for forthcoming International Union for Scientific Study of Population (IUSSP) seminars. In acute decompensated heart failure (AHF), an elevated cTn level has been repeatedly shown to correlate with increased short- and long-term mortality and, to a lesser extent, readmission rates. The possibility of regenerating whole plants from somatic differentiated cells emphasizes the plasticity of plant development. In addition, the value of mL for D-tryptophan was affected by pH, temperature and 1-propanol levels. The dynamic fracture toughness is found to be equal to the energy consumed by creating surfaces and lattice defects in agreement with theoretical predictions. Somatotropic hormone, human growth hormone, prolactin, ACTH and 17-ketosteroid levels indicated active/inactive adenomas. Then, receptor-mediated and myogenic excitation-contraction coupling mechanisms are discussed, in particular as regards the crucial role of membrane potential in these vessels. This hydrolysis product is identical to the free acid of latanoprost with the exception of a double, rather than a single, bond at the carbon 13-14 position.

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Liver and diabetes: nutritional and metabolic relationships between metabolic hepato-cholecystopathies and the diabetic syndrome. We report for the first time that PBMC and plasma levels of miR-150 and miR-146b-5p are predictive of HIV/AIDS disease progression and therapy. The catalytic constant and the Km values for 3,5-dichlorocatechol and oxygen were 34.7 s-1 and 4.4 and 652 microM, respectively, at pH 8 and 25 degrees C. The relevant photophysical properties of single fluorescent molecules and single SERS active surface-coated gold nanostars tagged with the Raman reporter molecule 4-mercaptopyridine are compared for imaging purposes. Role of ultrasonography in outcome prediction in subclinical hypothyroid patients treated with levothyroxine. The results of previous studies have suggested that Kid is an inhibitor of DNA replication, possibly acting at the onset of initiation. A retrospective review of medical records of new dermatology patients from January 2011 to December 2013 at a single urban safety-net hospital outpatient dermatology clinic with a closed pharmacy system. However, the diagnosis of LGL leukemia in the presence of pancytopenia is very challenging. Prevention of mother to child transmission of HIV in Burkina Faso: breastfeeding and wet nursing. Surprisingly, the degree of crystallinity in felodipine and the ease of tablet disintegration played a more significant role on the felodipine dissolution rate than the matrix lipophilicity.

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