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Aplaket (Ticlopidine)
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Aplaket

Aplaket is used to prevent strokes in people who cannot take aspirin or for whom aspirin has failed to work. It may also be used in combination with aspirin following certain types of heart procedures (such as coronary stent implant).Aplaket works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.

Other names for this medication:
Aplaket, Astic, Taispin, Ticlantin, Ticlobest, Ticlogard, Ticlogaurd, Ticlop, Ticlopid, Ticlopidine, Ticlovas, Tikla, Tikleen, Tilkon, Tyklid

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Nimotop, Calan, Eldepryl, Uroxatral, Medrol, Propecia, Aceon, Ritromine, Arthopan, Clorocef, Neblic, Zetia, Famorila, Flocare, Tavaloxx, Naxuril, Lipigan,

Also known as: Ticlopidine

Description

Ticlopidine is used to lessen the chance of having a stroke. It is given to people who have already had a stroke and to people with certain medical problems that may lead to a stroke. Because ticlopidine can cause serious side effects, especially during the first 3 months of treatment, it is used mostly for people who cannot take aspirin to prevent strokes.

A stroke may occur when blood flow to the brain is interrupted by a blood clot. Ticlopidine reduces the chance that a harmful blood clot will form, by preventing certain cells in the blood from clumping together. This effect of ticlopidine may also increase the chance of serious bleeding in some people.

This medicine is available only with a doctor's prescription.

Dosage

Ticlopidine should be taken with food. This increases the amount of medicine that is absorbed into the body. It may also lessen the chance of stomach upset.

Take this medicine only as directed by your doctor. Ticlopidine will not work properly if you take less of it than directed. Taking more ticlopidine than directed may increase the chance of serious side effects without increasing the helpful effects.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For prevention of strokes: Adults—1 tablet (250 mg) two times a day, with food. Children—It is not likely that ticlopidine would be used to help prevent strokes in children. If a child needs this medicine, however, the dose would have to be determined by the doctor. For prevention of strokes or heart attack following heart stent procedure: Adults—1 tablet (250 mg) two times a day, with food together with your doctor's recommended dose of aspirin for up to 30 days following the procedure Children—It is not likely that ticlopidine would be used to help prevent strokes or heart attack in children. If a child needs this medicine, however, the dose would have to be determined by the doctor

Overdose

Seek emergency medical attention if you think you have used too much of Aplaket-D.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Aplaket dosage information

Side effects

The most common side effects associated with Aplaket are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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Acute histological effects of interstitial hyperthermia on normal rat brain. As cells reached senescence, ejection of Brm1 from chromatin coincided with its dissociation from HP1 beta/RB and relocalization to protein complexes of lower molecular weight. Skin bridge versus rod colostomy in children - comparison between complications. The resulting 4-halo-oxazolones can serve as great potential precursors for the 3,4,5-trisubstituted oxazolones via a Pd-catalyzed cross-coupling reaction. He had undergone a shunt operation and three tumor removals during a 6-year period.

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Mandibular talon cusp in primary lateral incisor: a rare case report. Novel techniques provide surgeons with tools to treat increasingly complex fistulas with a focus on maintaining sphincteric functionality and limiting recurrence. Correlation between angiographically assessed vascularity and blood flow in hepatic metastases in patients with colorectal carcinoma. These include descriptions of expression patterns in human renal biopsies, cell culture studies to dissect paracrine versus autocrine signaling roles, and manipulation of VEGF-A expression in animal models using pharmacologic, biologic or genetic approaches. In this case, bisphosphonates have been shown to reduce bone resorption, thereby increasing the mass and mechanical resistance of bone. It is concluded that HGV co-infection is unlikely to influence the clinical detection of HCV-related OLP. This article provides an overview of clinical studies that have failed or been abandoned for other reasons. The stability of astigmatism and BSCVA shortened the postoperative visual rehabilitation time and provided a high quality of vision early in the postoperative period. There was no recurrence of cryptococcosis after four months of follow-up. Nonacceptance of negative emotions and inability to control impulsive behaviors emerged as additional mediators of the relation between insecure attachment styles and GAD symptoms.

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Because of the increased safety profile of these drugs, they can be used in circumstances in which the toxicity of the parent drug would normally limit their use, such as in chemoprevention of cancer. Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices. Genetic and environmental factors have been shown to control visually-guided eye growth and influence myopia development. Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. Prevalence and correlates of adult overweight in the Muslim world: analysis of 46 countries. Alterations of fast-reacting sulfhydryl groups of rat brain microsomes by ethanol. In this study, single molecule sequencing was used for noninvasive detection of trisomy 18 and 13. Using the highly sensitive technique of HRCT, we found evidence to suggest that the incidence of bronchiectasis in lifelong non-smoking RA patients may be much higher than previously reported. Nine-month angiographic and two-year clinical follow-up of novel biodegradable-polymer arsenic trioxide-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease.

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As an initial step towards understanding whether Ets-1 was a possible up-stream regulator of Bcl-2 expression in HEC-1-A cells and if so, whether curcumin could attenuate the Ets-1-induced up-regulation of Bcl-2 expression, cells were transiently transfected with an Ets-1/GFP (Green Fluorescence Protein) fusion construct and the transfectants were treated with 60 microM curcumin for 16 h, followed by whole cell lysate preparation for Western blot analysis of Bcl-2 protein contents. However, no significant differences were detected regarding the nanofibrils width as measured by atomic force microscopy (AFM) of air-dried films. The collagenous and non-collagenous protein of the canine intervertebral disc and their variation with age, spinal level and breed. Urease is also an immunogenic protein and is recognized by antibodies present in human sera. Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the developing retina and a significant cause of childhood blindness around the world. To critically analyse the formation, composition, ethnic variations and pathogenic potential of subgingival calculus in comparison with supragingival calculus. Therapeutic Effects of Acupuncture through Enhancement of Functional Angiogenesis and Granulogenesis in Rat Wound Healing. A specific marker for myocardial infarction in perioperative patients.

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Based on our findings, serum levels of CRP and ESR can provide helpful information for differentiation between epididymitis and other causes of acute scrotum. Jail Mental Health Resourcing: A Conceptual and Empirical Study of Social Determinants. Corticosteroid therapy and therapeutic education: experience of an internal medicine department. zooepidemicus strains into two 16S rRNA types and might possibly have consequences for the taxonomic position of these phenotypically indistinguishable strains of one subspecies. Timely rethoracotomies with low-frequency ultrasound treatment of the pleura promote more rapid inflammation elimination in the pleural cavity and prevents irreversible complications.

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Community-acquired pneumonia (CAP) is the most common infectious disease cause of death. The medical records with ocular images for these patients were analyzed. Greater spine density and elongated spines in the cortex, morphological synaptic abnormalities commonly observed in FXS, are at least partially restored by postnatal expression of a dominant negative (dn) PAK transgene in the forebrain. Papillary drusen associated with bird shot retinochoroidopathy and the Cacchi-Ricci syndrome. Graduate education of the foreign physician in obstetrics and gynecology in the United States. In contrast, immunoprecipitation of membranes with anti-dystrophin-coated beads yielded both cav-3 and dystroglycan. The progress of molecular biology research provides a very efficient opportunity for the diagnosis of drug resistance by in vitro method.

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Moreover, miR-326, miR-130a, miR-155, miR-210 and 4 miRNA-interactions were confirmed for the first time as independent predictors for survival by Cox regression model together with clinicopathological factors: Age, Gender and Recurrence. Better metabolic control and better general well-being seem to be achieved in many cases when poorly regulated patients with type 2 diabetes mellitus begin insulin treatment. Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of delta9-tetrahydrocannabinol. s-betaGluc in combination with HMR 1826 efficiently induces tumor cell killing both in cell culture and in vivo. Large defects of the anterior leaflet, due to transmural infection or lesions that encompass greater than one-third of the entire posterior leaflet with annular abscess, are not amenable to repair. Prevalence of Lyme Borrelia on tick collected in Shizuoka prefecture.

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Body fat distribution, lipoprotein metabolism, and insulin resistance: a lifetime of research on the pathophysiology of the human metabolic syndrome. This suggests that at least two pathways are involved in the nicotine response. In addition to the RP-A site in the FOX3 promoter, similar sequences were observed in other genes involved in peroxisomal function. The clinicopathological features of a lipomatous meningioma of the falx cerebri with an unusual histological pattern are presented. The asynchronous rise and fall of different cognitive abilities across the life span.

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Treatment of hypertension in the hemodialysis patient: beneficial or not?. RESPONSE more about: sunscreen use and duration of sun exposure: a double-blind, randomized trial. At late passages (above 24), the situation was quite different, with the persistence of one or two clones only, demonstrating a strong selective pressure occurring in vitro. Going forward, chronotherapy studies should also explore genetic, gender and age related differences. Extension to this model to humans considers the increased role of the brain, food quality and unique growth patterns of humans. Protein folding and deficiencies caused by dominant-negative mutants of hormones. Effects of iodinated salicylates on metabolism of rats and mice. Methyl CCNU produces a suppression of tritiated thymidine (3H-TdR) incorporation into DNA in vivo in normal bone marrow and gastrointestinal tissues which is different in magnitude and duration from that seen in L1210 ascites tumor in the same animals. We identified a 14-kb pyruvate carboxylase gene-containing fragment from a lactococcal C2-lambda phage genomic library. LDL oxidation was evaluated as both the susceptibility to in vitro oxidation and the presence of plasma anti-oxidized LDL omnicef brand name antibodies (as a marker for in vivo oxidation).

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We have covered literature associated with biomarkers, hormone receptors and hormone responsive signaling pathways in breast CSC. The ecological habitat and transmission of Escherichia coli O157:H7. However, in isolated human pulmonary veins two receptors are present, CysLT1 and CysLT2 (Figure 1). and fewer political and civil liberties also put countries at higher risk for physician emigration. Correlations between clinical/serologic factors and cardiovascular involvement were determined by univariate and multivariate analyses. Excellent repigmentation was observed at all grafted sites, especially on the face except for the lip and the alae nasae. Purification and characterization of cycloinulooligosaccharide fructanotransferase (CFTase) from Bacillus circulans MCI-2554. Increased GABAergic activity inhibits alpha-fetoprotein mRNA expression and the proliferative activity of the HepG2 human hepatocellular carcinoma cell line. After a target lesion was found, the lesion was observed for about 3 min and its discoloration was evaluated. In a randomised controlled trial, 256 schizophrenic outpatients with negative symptoms will be randomly allocated either to BPT or Pilates groups.

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Ischemic heart disease and antioxidants: mechanistic aspects of oxidative injury and its prevention. The Reactome database of curated biological pathways provides a tool for visualizing user-supplied expression data as an overlay on pathway diagrams, thereby affording an effective means to examine expression of the constituents of the pathway and determine whether all that are necessary are present. A rat model of cardiac hypertrophy was established using transverse abdominal aortic constriction (operation group). It has become a question of paramount importance to determine whether these cells integrate and interact with established neural circuitry after engraftment. Toxicological studies on stem bark, leaf and seed kernel of yellow oleander (Thevetia peruviana). It is postulated that child chronic fatigue syndrome (CFS) involves the autonomic nervous system, although the precise mechanism has not been clearly indicated. A decrease in proliferation activity and p53 activity illustrate the potential role of thermo-chemotherapy as a promising intravesical treatment. Experience in the organization of measures for decreasing morbidity caused by epidermophytosis in the coal mines. Anatomical basis for distal sartorius muscle flap for reconstructive surgery below the knee.

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Treatment with amoxicillin (3g IV q6h), cefotaxim, gentamycin (120mg IV q12h) and aciclovir was started empirically. We measured mRNA expression and DPP enzymatic activity in intestinal segments. We report a case of laparoscopically assisted penile revascularization for vasculogenic impotence. For patients with cancer, sleep is potentially affected by a variety of factors, including the biochemical changes associated with the process of neoplastic growth and anticancer treatments, and symptoms that frequently accompany cancer, such as pain, fatigue, and depression. A new 16S rRNA sequence characteristic of green nonsulfur bacteria and their relatives was discovered, raising to two the number of such sequences known to exist in the mat. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.

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CvLPRIT (Complete versus Lesion-only Primary PCI trial) is a U.K. Dietary carbohydrates effects upon magnesium metabolism in sheep. G9a belongs to the subfamily of histone H3 lysine 9 (H3-K9)-specific methyltransferases. Predictors of Changes in Smoking From Third Trimester to 9 Months Postpartum. Systemic therapy, pain relief and quality of life of breast cancer patients with bone metastasis. High levels of dietary sugar consumption may result in dysregulated glucose metabolism and lead to noroxin medication elevated cardiovascular disease risk via autonomic nervous system and cardiovascular dysfunction. Early diagnosis of urinary tract infections by nitrite demonstration with urine test paper. Molecular characterization and functional analysis of three pathogenesis-related cytochrome P450 genes from Bursaphelenchus xylophilus (Tylenchida: Aphelenchoidoidea).

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Automatic devices are prone to unreliable readings in patients with certain conditions. Factors that govern this dimerization are the steric and electronic demands of the catalyst and the substrate. The anti-gD BomAb reacted strongly with all BoHV-1.1, 1.2, and 5 isolates tested. The physician is often not attuned to the psychosocial aspects of patient care and is frustrated and uneasy with patients. The procedure showed the polyethylene element to be broken into three pieces in the area corresponding to the upper border. One-year follow-up evaluation of 260 premature infants with respiratory distress syndrome and birth weights of 700 to 1350 grams randomized to two rescue doses of synthetic surfactant or air placebo. The efficacy of Brazilian black mud treatment in chronic experimental arthritis. Gender, justice and work: a distributive approach to perceptions of housework fairness.

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All patients underwent CT, T2- weighted MRI and diffusion-weighted MRI. Arsenic and antimony removal from drinking water by adsorption on granular ferric oxide. Primary care settings of three integrated healthcare systems in the United States that participated in the Back pain Outcomes using Longitudinal Data (BOLD) registry. HAPTOGLOBIN AND TRANSFERRIN TYPES OF INDIANS FROM SANTA CATARINA, BRAZIL. For further study of the effects of the repairment of facial nerve with vein tubulation, we used horseradish peroxidase (HRP) retrograde mark method to observe the changes of the labeled cells in facial neucleus after the tubulation of rat facial nerve. In addition, the putative function of destrin (also known as ADF) had not been explored in this context despite the fact that it is expressed in all colon cancer cell lines examined. Molecular cytogenetic characterisation of a small ring X chromosome in a Turner patient and in a male patient with congenital abnormalities: role of X inactivation. Hepatitis B virus reactivation in patients with HBs antibodies after allogeneic hematopoietic stem cell transplantation.

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The maximum existing population is first defined in this approach in order to determine a better bound of the number reactions. Surgical management of hypogonadic patients with hypotrophic testicles and small penis: a novel, combined technique with an infrapubic approach. A methodological review following systematic principles was undertaken. Employer-incurred health care costs and productivity losses associated with cleocin t generic name influenza. The unique N-terminal sequences of p51(ferT) thus interfere with its ability to autophosphorylate in vivo.

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