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Aplenzin (Bupropion)

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Aplenzin is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Aplenzin is an effective antidepressant on its own, but it is also popular as an add-on medication in the cases of incomplete response to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant.

Other names for this medication:
Aplenzin, Budeprion, Bupdep, Bupraset, Bupron, Bupropion, Ession, Nicotex, Smoquit, Unidep, Zyban

Similar Products:
Ambien, Priligy, Sporanox, Moduretic, Colospa, Strattera, Valium, Vantin, Aldactone, Sustiva, Glyson, Cycram, Evafem, Rextop, Calaptin,

Also known as: Bupropion


Aplenzin XL is an antidepressant used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Too much of this medicine can increase your risk of a seizure.

You may take Aplenzin XL with or without food.

Swallow the extended-release tablet whole and do not crush, chew, or break it.

You should not change your dose or stop using Aplenzin XL suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

If you take Zyban to help you stop smoking, you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the first 2 weeks of treatment. Talk to your doctor if you have trouble quitting after taking Zyban for 7 to 12 weeks.

Your doctor may prescribe a nicotine replacement product (such as patches or gum) to help you stop smoking. Start using the nicotine replacement product on the same day you stop (quit) smoking or using tobacco products.

Some people taking Aplenzin XL (Aplenzin or Zyban) have had high blood pressure that is severe, especially when also using a nicotine replacement product (patch or gum). Your blood pressure may need to be checked before and during treatment with this medicine.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You may have nicotine withdrawal symptoms when you stop smoking, including: increased appetite, weight gain, trouble sleeping, trouble concentrating, slower heart rate, having the urge to smoke, and feeling anxious, restless, depressed, angry, frustrated, or irritated. These symptoms may occur with or without using medication such as Zyban.

Smoking cessation may also cause new or worsening mental health problems, such as depression.

This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use Aplenzin XL.

Store at room temperature away from moisture, heat, and light.

Detailed Aplenzin XL dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Protect from light and humidity. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Aplenzin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Aplenzin XL if you are allergic to it, or if you have:

a seizure disorder; an eating disorder such as anorexia or bulimia; or if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take Aplenzin XL. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Aplenzin XL to treat more than one condition at a time. If you take this medicine for depression, do not also take Aplenzin XL to quit smoking.

Aplenzin XL may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Tell your doctor if you have ever had:

a head injury, seizures, or brain or spinal cord tumor; narrow-angle glaucoma; heart disease, high blood pressure, or a heart attack; diabetes; kidney or liver disease (especially cirrhosis); depression, bipolar disorder, or other mental illness; or if you drink alcohol.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether Aplenzin XL will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of bupropion on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Aplenzin XL is not approved for use by anyone younger than 18 years old.

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Cerebral crises during acclimatization under conditions of tropical humidity. Combat casualties who present pulseless or in extremis who were injured as a result of an explosive/blast injury mechanism resulting in a primary extremity injury may have a survival benefit from undergoing a RT in an austere environment. This study assesses the value of contrast magnetic resonance imaging (MRI) using ultrasmall superparamagnetic iron oxide particles (Combidex, Advanced Magnetics, Inc., Cambridge, MA) to characterize and stage neck nodes. Independent contributions of error-monitoring effort and verbal WM to executive functions may reflect distinct contributions of prefrontal and medial frontal cortical dysfunctions. Impact-induced muscle damage and urinary pterins in professional rugby: 7,8-dihydroneopterin oxidation by myoglobin. This journal requires that authors assign a level of evidence to each article. These results indicate that beta 1 integrins play an important role in the tissue attachment, migration, invasion and metastasis of human carcinoma cells, and that this new monoclonal antibody is useful for studies aimed at prevention of metastasis. Continuous biplane transesophageal echocardiography (TEE) was performed in a 64-year-old woman who had an acute pulmonary embolism. Effect of ether on evoked potentials of cerebral cortex under conditions of hexenal narcosis. Multivessel coronary thrombosis in a patient with idiopathic thrombocytopenic purpura.

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Assessment of coronary stenosis severity and transmural perfusion gradient by myocardial contrast echocardiography: comparison of gray-scale B-mode with power Doppler imaging. Cognitive and neurological deficits fully reversed more than 1 year after seizure remission, and were associated with normalization of FDG-PET and EEG. Mechanisms underlying long-term changes in synaptic function are likely to be at the heart of many cognitive and emotional processes in humans. However, in the presence of antiverse process, damaging stress occurs in the next higher joint. Recently, many new findings have been uncovered about the relationship between M(3)-mAChR and cardiac diseases, including cardiac ischemia, pathological cardiac hypertrophy, cardiac arrhythmias, cardiac conduction and heart failure. Two factors significantly affected network motif structure: the proportion of dyads that were observed to interact and the interaction rates of the top-ranked individuals.

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Generic evidence of asphyxia (acute pulmonary emphysema and petechiae) allowed a diagnosis to be formulated. Under some circumstances adaptive management can also be a viable alternative to detailed CE assessments. Pathological and clinical aspects of degenerative disease of the knee. Autoradiographic analysis of 125I-substance P binding in rat spinal cord following chronic constriction injury of the sciatic nerve. Such findings suggest the importance of addressing craving beliefs during smoking cessation treatment, especially for less dependent smokers whose craving beliefs are associated with abstinence self-efficacy across multiple situations. Agriculture plays a major role in the global fluxes of the greenhouse gases carbon dioxide, nitrous oxide, and methane.

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A mixture of dissipative hard grains generically exhibits a breakdown of kinetic energy equipartition. This study examines the prevalence of anatomic variation and asymmetry in female thoracic contour and evaluates their effect on breast projection. Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo. Furthermore, amoxycillin dose-dependently inhibited the phorbol myristate acetate-stimulated luminol-dependent chemiluminescence responses of isolated human poylmorphonuclear leukocytes in vitro. For lead optimization and the further structural diversification of natural-product libraries, combinatorial biosynthetic engineering has also become indispensable. The effect of predictor variables on pain severity was examined with multivariate regression. There is a need for reliable data on gametocytogenesis from field studies. The influence of fluoride anions on the fluorescence and gel-sol processes is a result of the dissociation of intermolecular hydrogen bonds by bonding of fluoride anions with urea groups of the gelator. Some viruses can induce the secretion of IL-18 for immune evasion.

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Practice guidelines for the management of community-acquired pneumonia in adults. Atrial stimulation by means of floating electrodes: a multicenter experience. Previously, we demonstrated that irradiation induces an increase in the expression of BN/GRP in the innervation of the salivary glands in rats. Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production. Children with Down syndrome (DS) carry an elevated risk of developing clonal hematologic disorders. Spatial accuracy demand in aiming movements: kinematic analysis of subtended angle and tolerance width. Eight dry mandibles with 236 selected markers were scanned by CBCT scanner, and the distance from alveolar ridge crest to cemento-enamel junction were measured on every marker by the images of CBCT. This study presents the results of syphilis screening from 2000 to 2004 and describes its impact on Canadian syphilis reporting and epidemiology. The expression of EGF mRNA and EGF receptors in human trabecular meshwork cells in vitro. However, apart from the established basal archaeal transcription system, little is known about the modulation of gene expression in archaea.

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A similar pattern of sensitivity to ouabain was observed in bilaterally vagotomized animals. However, these beneficial effects seem to depend on the type and duration of the used feeding protocol. The underwhite (uw) locus acts autonomously and reduces the production of melanin. Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors. Does posturography differentiate malingerers from vertiginous patients?. At present, a better prognosis of stroke is more often the consequence of good general management than of a specific therapy. This symptom of growth disruption is used here to examine possible changes in health occurring at the transition between the Bronze Age and Iron Age in Jordan, through examination of enamel hypoplasias in skeletal remains from two tombs at the archaeological site of Pella. Consecutive records during 1990 and 1991 resulted in 331 patients at the acute level and 97 at the subacute.

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Optimal substituents on the terminal urea nitrogen are cyclohexyl, bicycloheptenylmethyl, and in certain cases propyl, 7-oxabicycloheptanylmethyl, and adamantyl. The optimum temperature was 55 degrees C and the enzyme was stable below 50 degrees C. Hypertension and diabetes mellitus relate to one another aetiologically and prognostically. Obestatin is present not only in the gastrointestinal tract, but also in the spleen, mammary gland, breast milk, and plasma. Further research is required to explore the underlying mechanisms and clinical relevance and to determine whether the use of age-related PTH reference ranges improves diagnostic accuracy, particularly in elderly individuals.

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Southern blot analysis reveals that the ceratotoxin gene family is not specifically amplified in the female reproductive accessory glands of C. The forkhead transcription factor FoxH1 (also known as Fast1) is a component of the Nodal signaling pathway. The detailed evaluation of MSI in tumor samples from 71 STS patients was performed by pentaplex PCR of the MSI markers NR-27, NR-21, NR-24, BAT-25, and BAT-26, followed by capillary electrophoresis. Several observations suggest an interaction of the sodium channel alpha-subunit with the cytoskeletal structures. The high protein diet-fed group had greater liver weight and zinc and GSH concentrations after TNF than the group fed the low protein diet supplemented with alanine. Measles vaccination as a risk factor for inflammatory bowel disease. Six years relapse-free treatment of a case with Langerhans cell histiocytosis grade III treated with thalidomide and prednisone. The results show that adherence to wearing custom-made footwear is insufficient, particularly at home where patients exhibit their largest walking activity.

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It is concluded that hysterectomy leads to a decreased LH max dose of risperdal secretion by the pituitary gland, but has no influence on the maximal progesterone concentrations during PSP. In the present study, we evaluated whether scheduled administration of acetaminophen (paracetamol) for pain management after ESS would allow faster recovery to normal daily activities compared with acetaminophen administered on an as needed basis. On the differential diagnosis of erythremia and secondary erythrocytoses. Community Growth Monitoring requires less time and is effective in measuring the growth of children of a community as a whole, rather than the individual child. In later extra-striate areas neurons with larger receptive fields integrate information across the visual field. Apparent Ca absorption was lower in rats administered omeprazole (30 mg/kg body weight per d) for 8 d than in rats administered the vehicle. However, VR-QOL in type 2 diabetic patients with macular oedema was similar to those individuals with ARMD.

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Further understanding of KIT and RAS signalling in TGCTs may lead to novel therapeutic approaches for these tumours. These results suggest that obese, postmenopausal women with a lower initial SHBG and more visceral obesity have a greater decrease in leptin with weight loss, independent of the amount of weight lost. Patients with large baseline DWI lesion volumes who achieve early reperfusion appear to be at greatest risk of SICH after tPA therapy. Left out in the cold: arguments against non-medical oocyte cryopreservation. The prevalence of the problem is presented, followed by a discussion of contributory factors and the effects violent incidents may have on victims. The lichen species Polychidium muscicola was found in South Korea for the first time and this is the first record of the genus Polychidium from the Korean peninsula. We reexamined 43 patients with stable knees at a mean of 13 years after arthroscopic meniscectomy. Cortical reorganization after experimental traumatic brain injury: a functional autoradiography study. The differentially conserved residues of carbamoyl-phosphate synthetase. STR was increased for epididymal sperm from the males treated with SASP when compared with xanax pill blue 029 the controls.

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Improving outcomes from acute kidney injury: report of an initiative. From public health to international law: possible protocols for inclusion in the Framework Convention on Tobacco Control. Bovine insulin was without effect on GVBD or steroid production. Protection was better in turkeys given the LaSota spray vaccine at 4 weeks and 30 days later than in turkeys given one vaccination by spray or intramuscular route or exposed 4 times at 10-day intervals by the aerosol route. Results of the effect and process evaluation will become available in 2013. Endoscopic therapy for the treatment of pain in chronic pancreatitis: a success story in tropical pancreatitis. Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients.

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