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Aptric (Amitriptyline)

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Aptric is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine. Aptric is normally taken before bedtime because it can make you feel sleepy.

Other names for this medication:
Abamax, Amitar, Amitin, Amitop, Amitrac, Amitrim, Amitriptyline, Amiwel, Amizep, Amline, Amoten, Amtipax, Amypres, Anitryp, Bluneel, Cotrip, Emotrip, Eptanol, Estiline, Maxitrip, Mitryp, Nextrip, Normaline, Raitrip, Ronet, Trixide, Zodep

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Also known as: Amitriptyline


Aptric (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Aptric is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Aptric dosage information


If you overdose Aptric and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Aptric overdosage: seizures, loss of consciousness for a period of time, seeing things or hearing voices that do not exist, agitation, feeling drowsy, rigid muscles, vomiting, high temperature, cold body temperature, problems concentrating, abnormal heartbeats, confusion.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aptric are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Aptric if you are allergic to Aptric components. Do not take Aptric if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Aptric if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Aptric if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Aptric you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Aptric if you are going to have a surgery. It can be dangerous to stop Aptric taking suddenly.

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Wilhelm Zwick successfully transmitted Borna disease to rabbits in 1924. Hypomagnesemia and renal magnesium wasting in patients treated with cisplatin. This review emphasizes the latest discovery in the field of miRNA research involved in cancer, biomarkers, and therapeutics. These devices were evaluated in terms of their impedance spectra, pulse-echo response, and surface displacement characteristics. Cytogenetic analyses of malignant peripheral nerve sheath tumors (MPNST) and malignant triton tumors (MTT) are few to date. Colour blindness was associated with presentation with more advanced bladder tumours. The stage of 15 degrees orientation difference was learned by 4 N cats, 2 C cats, and 1 BD cat. Using cytotoxicity and cytokine release assays as functional readouts, we demonstrated that CD1c.

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Individuals who drink heavily are at an increased risk for adverse consequences of drinking and progression of their drinking habits to abuse or dependence. Partial knockdown of eIF5A-1 by siRNA led to inhibition of HIV-1 gene expression that was non-additive with drug action. They also continue to have elevated rates of panic disorder and to evidence some confusion about the cause of their symptoms. Also, with regard to the association of CCR5 Delta32 with disease severity in RA and SLE, more data are needed to draw firm conclusions. Here time-resolved visible transient absorption spectroscopy ( micardis plus generic brand femtosecond to second) has been used, in conjunction with time-resolved IR spectroscopy (femtosecond to nanosecond) and cryotrapping techniques, to follow the entire photoconversion of the blue-absorbing states to the green- and red-absorbing states of the full-length form of Tlr0924 CBCR. Effect of equimolar amounts of long-chain triglycerides and medium-chain triglycerides on small-bowel transit time in humans.

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Coadministration of thalidomide and cyclophosphamide gave markedly greater activity against Colon 38 tumour compared with either drug alone. HPV infection was studied via polymerase chain reaction (PCR) using two PCR primer sets, to determine DNA integration. The stability and degradation of a new biological pesticide, pyoluteorin. A Critical Comparison of Methods for the Analysis of Indigo in Dyeing Liquors and Effluents. Gynecologic patients administered GnRH-a as therapy for ovarian hyperandrogenism, premenstrual syndrome, dysfunctional uterine bleeding, uterine leiomyomata, and symptomatic endometriosis. We sought to determine the influence of IgE-mediated sensitization on adenotonsillar disease in children. Hepatitis has been a recent focus with the development of a National Strategic Plan on Hepatitis and plans to subsidize HCV treatment. Overexpression of Akt1 mutants that bind JIP1 reduced excitotoxic apoptosis. Socioeconomic indicators of heat-related health risk supplemented with remotely sensed data.

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Familial preexcitation syndrome is linked to mutations in PRKAG2. The activities of the peroxidase enzymes responded different to various substrates and effectors and had different thermal stabilities and pH and temperature optima. However, the developmental and morphological basis of feather shape is not simple, and the developmental processes involved in vane width asymmetry are poorly understood. The SND technique just needs one step to obtain clear ridge details in a wide pH range (2.5-5.0), whereas the standard multi-metal deposition (MMD) technique requires six baths in a narrow pH range (2.5-2.8). ApoE4 phenotype was independently associated with an increased risk of carotid atherosclerosis and elevated LDL-cholesterol levels in asymptomatic middle-aged Japanese men. Using lymph nodes and pre- and postoperative peripheral blood dissected from 30 patients with pT3N0 prostate cancer treated by radical prostatectomy, we used RT-PCR for prostate-specific membrane antigen (PSM) and serum prostate-specific antigen (PSA) to determine the presence of prostate cancer. Since macrophages, like osteoclasts, are particularly susceptible to BPs, these observations support the recent suggestion that the mechanism by which BPs inhibit bone resorption may involve osteoclast apoptosis. Postoperative culture positive surgical site infections after the use of irradiated allograft, nonirradiated allograft, or autograft for spinal fusion. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidine analog that may be an endogenous imidazoline receptor ligand, can interact with both I1 and I2 imidazoline receptors as well as alpha 2-adrenoceptors, although, interestingly, other guanidines such as guanabenz are highly selective for alpha 2-adrenoceptors versus I1 receptors.

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Treatment of advanced, metastatic soft tissue sarcoma: latest evidence and clinical considerations. Individuals with DSI experience higher rates of adverse events across many health-related outcomes and QIs. Surgical bone defects were created in 24 adult rabbits and repaired with either ADDM and PTFE (experimental group) or PTFE alone (control group). The evolutionary computation is a different concept, which can find many different solutions of the problem. Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical flomax dosage instructions intractability and requires surgical treatment. 126 couples in five fertility centers in Hungary filled out the FertiQoL and Beck Depression Inventory and answered some sociodemographic questions. Of 269 octogenarians who underwent coronary artery bypass grafting at our institution between January 1995 and May 1999, 172 had the operation with CPB (CPB group) and 97, without CPB (off-pump group). The overexpression of c-myc associated with uncontrolled cell proliferation is a frequent genetic event in androgen-refractory prostatic neoplasia. Analogous unsubstituted compounds stimulated cleavable complex formation but were considerably less potent than the corresponding 5,6-bridged compounds.

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