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Atipam (Lorazepam)
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Atipam

Atipam, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3- dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one. It is a nearly white powder almost insoluble in water. Each Atipam tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of Atipam. The inactive ingredients present are lactose monohydrate, magnesium stearate, microcrystalline cellulose, and polacrilin potassium.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Danocrine, Xeloda, Sumycin, Cordarone, Cymbalta, Kamagra, Avelox, Depakote, Micardis, Vantin, Sarotena, Bonetuf, Metochlopramide, Plusgin, Loxin, Alprogard, Clobetasol,

Also known as: Lorazepam

Description

Atipam belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Atipam are categorized based on how fast they work. Atipam is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.

Dosage

When given intramuscularly, Atipam Injection, undiluted, should be injected deep in the muscle mass.

Injectable Atipam can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Atipam Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Atipam Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.

Overdose

In cases of a suspected Atipam overdose, it is important to establish whether the patient is a regular user of Atipam or other benzodiazepines, since regular use causes tolerance to develop. Also, one must ascertain whether other substances were also ingested.

Signs of overdose range through mental confusion, dysarthria, paradoxical reactions, drowsiness, hypotonia, ataxia, hypotension, hypnotic state, coma, cardiovascular depression, respiratory depression, and death.

Early management of alert patients includes emetics, gastric lavage, and activated charcoal. Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil.

Patients are ideally nursed in a kind, nonfrustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. Opportunistic counseling has limited value here, as the patient is unlikely to recall this later, owing to drug-induced anterograde amnesia.

Storage

Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Atipam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Atipam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Atipam should be avoided in people with:

Sleep apnea – Sleep apnea may be worsened by Atipam's central nervous system depressant effects. It may further reduce the patient's ability to protect his or her airway during sleep.

Myasthenia gravis – This condition is characterized by muscle weakness, so a muscle relaxant such as Atipam may exacerbate symptoms.

Pregnancy and breast feeding – Atipam belongs to the Food and Drug Administration (FDA) pregnancy category D, which means it is likely to cause harm to the developing baby, if taken during the first trimester of pregnancy. Evidence is inconclusive whether Atipam, if taken early in pregnancy, results in reduced intelligence, neurodevelopmental problems, physical malformations in cardiac or facial structure, or other malformations in some newborns. Atipam given to pregnant women antenatally may cause floppy infant syndrome in the neonate, or respiratory depression necessitating ventilation. Regular Atipam use during late pregnancy (the third trimester), carries a definite risk of benzodiazepine withdrawal syndrome in the neonate. Neonatal benzodiazepine withdrawal may include hypotonia, reluctance to suck, apneic spells, cyanosis, and impaired metabolic responses to cold stress. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth. Atipam may also inhibit fetal liver bilirubin glucuronidation, leading to neonatal jaundice. Atipam is present in breast milk, so caution must be exercised about breast feeding.

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beta-Amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration. These nanochannels have some properties similar to biological channels, such as selectivity, voltage-dependent current fluctuations, ionic rectification current and ionic gating, etc. We found no differences in the abundance and biodegradation potential of theses communities at the three sites, and only a slightly elevated number of hydrocarbon degraders at one of the marinas. Short-term efficacy of laparoscopy-assisted vs open radical gastrectomy in gastric cancer. Gas bremsstrahlung shielding calculation for first optic enclosure of ILSF XPD beamline.

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To test the cytokine production of peripheral blood mononuclear cells in a group of HIV-infected women with breast enlargement and lower limb wasting while receiving antiretroviral therapy (ART) including a protease inhibitor. Specifically, I examine the discrepancy which exists between medical knowledge and nursing education, and show this discrepancy to be a difference in type, not quality. In patients undergoing fusions and instrumentation for foraminal stenosis, distraction of the lumbar spine may improve the dimensions of the intervertebral foramen. In the following stages of delivery (I, II, III) it was assumed the increase in enzyme activity in urine. They compare favourably with previous branched building blocks as regards to steric hindrance and branched effect. The effect of the opening of Waitakere ED on ED presentations to other hospitals was assessed using control charts. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. Since no global DNA methylation change was detected between first and third trimesters, LINE-1 methylation changes appeared to be a specific epigenetic entity contributing to placental development.

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This randomized, evaluator-blinded, split-face trial compared the safety and efficacy of two variable-particle NASHA fillers in the correction of nasolabial folds in patients with Fitzpatrick skin types IV, V, and VI. maculans (A22) that penetrates stomatal apertures of Col-0 and Ler-0 five to seven times more often than the wild-type isolate is described. Standard halogen irradiation at reduced intensity delayed the start and slowed down the progression of shrinkage strain, but (except for Z250) as well produced lower hardness. Levels of p16(INK4a) increased exponentially and then saturated at later chronologic ages. Our comparative study of tip terminations shows that two subatomic features can appear for a single adatom when it is imaged by a Si(001)-type tip having two dangling bonds on its apex, while only one feature would appear if it were imaged by a Si(111)-type tip having one dangling bond on the apex. Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. All patients fulfilled criteria for resectability as assessed by computed tomography: no metastatic disease, no encasement of the superior mesenteric or hepatic arteries, and a patent superior mesenteric-portal venous confluence. This was a retrospective health record review of children aged 3 to 17 years presenting to a tertiary pediatric emergency department (ED) with suspected appendicitis. Our aim was to assess its cost-effectiveness compared with usual orthopaedic care. In addition to bronchodilator and anti-inflammatory therapy, exacerbations in patients with chronic obstructive pulmonary disease (COPD) are often treated with antibiotics.

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In contrast to dominant perspectives, being autistic was not considered a hindrance to aging well. The outlines of the neuroanatomical structures are drawn onto transparencies which are scanned. Significant differences were observed among the dietary groups and between sexes in several values, but all animals appeared to be healthy and robust. The effect of demographic variables and vascular conditions offers opportunities for prevention. FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY PROTOCOL FOR STANDARDIZED PRODUCTION OF CLINICAL PRACTICE GUIDELINES, ALGORITHMS, AND CHECKLISTS - 2017 UPDATE.

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SKA1 over-expression promotes centriole over-duplication, centrosome amplification and prostate tumourigenesis. Asthma mortality rates have been increasing despite our improved understanding of the pathophysiology of asthma and advanced methods of treatment. Evaluating geographic imputation approaches for zip code level data: an application to a study of pediatric diabetes. Because of the broad-spectrum antibacterial activity, established mode of action, lack of rapid resistance development, and tolerance by human cells, the C(12)-TA scaffold may also serve as a new lead compound for the development of antimicrobial therapeutics. All were typical of the species in biochemical properties, except that they were NAD-independent, and all were Page serovar A.

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A further aim was to compare the prolactin response following remoxipride and thyrotropin release hormone (TRH) during the refractory period. Parallel analyses of 77 blood samples using the existing BR6 assay and our new DB6 assay demonstrate that the DB6 assay produces cleaner bivariate flow histograms with generally lower variant cell frequencies and lower coefficients of variation on replicate analyses of individual blood samples. Deformation and failure of rock samples probed by T1 and T2 relaxation. Visual short-term memory load affects sensory processing of irrelevant sounds in human auditory cortex. In the sample studied Taguchi ureterocystoneostomy proved to be a more rapid method without increasing the incidence of urological or anastomotic complications. Longitudinal split tears of the peroneus brevis tendon have been increasingly reported as a source of lateral ankle pain and disability.

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Uni- and multivariate Cox regression analyses were used to examine firstly the prognostic value of preoperative QoL and several clinical factors, and secondly of postoperative QoL, several clinical factors, and pathological staging. Equisetum giganteum L and Copaifera reticulate Ducke efficiently blocked HSV-2 infection of cell cultures without major cell cytotoxic effects. Cellular expression of alpha 4 subunit mRNA of the nicotinic acetylcholine receptor in the developing rat telencephalon. Urine samples from 64 PCa patients and 51 individuals diagnosed with BPH were analysed using 1H nuclear magnetic resonance (1H-NMR). Laparoscopic lateral lymph node dissection is safe and feasible for cancer stage II to III low rectal cancer and is associated with similar oncological outcomes as open lateral lymph node dissection. If adopted, this legislation has the potential to set back important improvements to professional regulation that have been implemented in Australia in the past 20 years. We hypothesised change in synovitis assessed using dynamic imaging could explain the reduction in pain. PCR amplification and DNA sequencing of SRV-2 from archived tumor tissues. Potential gain in precision and power by matching on strong risk factors in case-control studies: the example of laryngeal cancer.

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