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Avdol (Tramadol)

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Avdol is an opioid (narcotic) pain reliever. It works by binding to mu-opiate receptors in the brain and changes how you feel and respond to pain. Avdol is usually started at 25 mg per day. After slowly raising the dose over several days, a typical dose would be 50 to 100 mg by mouth every 4 to 6 hours as needed for pain.

Other names for this medication:
Accupain, Acuvin, Antram, Atdol, Bludol, Contramal, Damadol, Decotram, Didol, Dolodol, Inodol, Ivydol, Jpdol, Kevtram, Midol, Muzox, Mydol, Nictram, Oshdol, Ospidol, Paintrol, Paxmax, Radol, Rimol, Rybix, Siatram, Simol, Spasteez, Taramol, Tramache, Tramak, Tramalex, Tramataur, Trampar, Trapain, Trasic, Trazac, Trectadol, Tryme, Ultraspas, Veeradol, Xidol, Zotadol

Similar Products:
Aygestin, Diflucan, Zithromax, Aricept, Allegra, Viramune, Thorazine, Suprax, Dostinex, Lopid, Losazid, Cardules, Tidocol, Mobic, Perindan,

Also known as: Tramadol


Avdol (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Avdol is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Avdol ER) is for around-the-clock treatment of pain. Avdol ER is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Avdol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Avdol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Avdol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Avdol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Avdol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Avdol should not be given to a child younger than 12 years old. Avdol ER should not be given to anyone younger than 18 years old.

Do not give Avdol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Avdol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Avdol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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A total of 1,152 subfertile women undergoing their first in vitro fertilization (IVF) cycle. The corticotrophin-releasing hormone-proopiomelanocortin (CRH-POMC) system in the skin coordinates pigmentation and the immune response. UNUSUAL CAUSES FOR SUDDEN UNEXPECTED DEATH OF REGRESSED HOSPITALIZED SCHIZOPHRENIC PATIENTS. Serum 25(OH)D was measured using isotope-dilution liquid chromatography-tandem mass spectrometry. In contrast, yeast expressing GFP-Gal7p but lacking Gal1p (GALK), Gal10p (GALE), or both do not demonstrate spots in the majority of cells, implicating a role, either direct or indirect, for these other Leloir proteins in the Gal7p localization process. Wound education: American medical students are inadequately trained in wound care. The ocular globe is incompletely developed at the time of birth. The demographic data, laboratory investigations and diagnoses were collected. Phenotypic features, androgen receptor binding, and mutational analysis in 278 clinical cases reported as androgen insensitivity syndrome.

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Monolayer cultures of WI-38 cells from passages 18 to 60 were exposed to ultraviolet radiation, or to N-acetoxy-AAF, or to gamma-rays. Report of 37 cases with a study of factors influencing prognosis. When possible, we calculated and reported median effect size (odds ratio (OR), interquartile ranges (IQR)). Neuronal expression of p35 was also found to attenuate neurodegeneration associated with the excitotoxic glutamate analogue kainic acid (KA) in vitro and in vivo. Investigating the relationship between the demographic variables associated with suicide in different seasons, among suicidal people in the Shahid Mohammadi Hospital, Bandar Abass, Iran. Ictal recordings disclosed stereotyped seizures starting from the right mesial frontal. We emphasize to demonstrate the helpful of intensive care and the role of early surgery for a good prognosis.

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LXR, a nuclear receptor that defines a distinct retinoid response pathway. The KD (equilibrium dissociation constant) and the Bm (total number of binding sites per follicle), were estimated as 4 x 10(-8) M and 8 x 10(7) respectively. In all mice immunized with the pPcMSP1(19)-HBs, a Th1-specific response, including the production of anti-MSP1(19)-specific immunoglobulins predominantly of the immunoglobulin G2a subtype and reacting almost exclusively against discontinuous epitopes, was elicited. of the gland), followed by a rapid decrease to reach a plateau level of 1 mg maltose/30 s later than 1.5-2 min. Recently, a better understanding of the relevant anatomy and the evolving therapeutic modalities (including both open and closed techniques) have contributed to a renewed interest in aesthetic surgery in the forehead and brow area. Tandem zinc-finger gene families in mammals: insights and unanswered questions. The mutations were largely found to fall into a limited number of categories.

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The free arginine content was strongly reduced in the chemically induced recessive mutant tup5-1, root growth was restored by supplementation with arginine and its metabolic precursors, and a yeast (Saccharomyces cerevisiae) ACOAT mutant was complemented by TUP5. We are gradually developing a better understanding of how the gut works during critical illness, which has implications for optimizing the delivery of nutrition and thereby improving nutritional and clinical outcomes. Profile of paediatric umbilical hernias managed at Federal Medical Centre Umuahia. Although studies suggest that most addicted persons who need treatment do not receive it, innovative methods such as the one described here can help increase the number of pregnant women who engage in treatment, with likely benefits to the client, her unborn baby, and other children whom she may parent. In this review, we discuss several issues related to alternative splicing with a special emphasis on identification strategies based on bioinformatics. The GST-NDK protein was capable of transferring gamma-phosphate from ATP to nucleoside diphosphates such as GDP, CDP, TDP and UDP. Targeting the mineralocorticoid receptor in cardiovascular disease. The results indicate that the current components are caused by three different populations of light-sensitive channels. UT usually is a transudative pleural effusion that presents in patients with obstructive uropathy and it may occur following surgical procedures in the ureter or kidney such as ESWL, PCNL, and URS. Enzymatic formation of modular cell-instructive fibrin analogs for tissue engineering.

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In the in vivo study, we found obvious patterns of serum cytokine changes depending on the volume of tissue irradiated (2-mm vs. Epinephrine (5 mug i.c.) showed both centrally mediated alpha- and beta-sympathomimetic effects. Although LVIHR may be challenging, it has the potential to be considered a primary approach for most ventral and incisional hernias, regardless of patient status or hernia complexity. The beta subunits of these channels modify calcium currents through pore-forming alpha1 subunits of the high-voltage- activated calcium channels. The faecal occult blood test has been added to the yearly program of cancer prevention for each individual age 45 and higher. To return to the catalytic cycle, the cob(II)alamin forms of both the bacterial and mammalian enzymes must be reductively remethylated. The posterior means of genetic correlations between SC and AFC, FCI, HP, STAY were up to -0.70, -0.25, 0.48, and 0.29, respectively.

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Furthermore, histamine-induced release of intranuclear OT was also prevented by blockade of alpha-adrenergic receptors. In acute idiopathic TTP, decreased vWf metalloproteinase is the result of autoantibodies against the enzyme. We showed that T/E fusion can activate NF-kB pathway by increasing phosphorylation of NF-kB p65 Ser536 (p536), but the function of p536 has never been studied in PCa. Biliary conducts deep cannulation is a requirement for therapeutic Endoscopic Retrograde Cholangio-Pancreatography (ERCP). Imaging-guided needle puncture, infiltration and lavage of rotator cuff calcifications. We speculate that in this already compliant population, more targeted advice is necessary to increase compliance. Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation, as well as tumorigenesis and progression. Both systems were noninducible, stereospecific, dependent on temperature and pH, and sensitive to sulfhydryl-blocking reagents. The anti-inflammatory effects of resveratrol on human peripheral blood mononuclear cells are influenced by a superoxide dismutase 2 gene polymorphism.

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Social capital and social cohesion show complex, often unhealthy, relationships with mental health, suggesting considerable drawbacks in making social capital a key focus among policymakers. In this series of experiments we demonstrate that CT4S cells proliferate to recombinant as well as to naturally produced IL-12, and that IL-4 and IL-12 synergize in supporting proliferation of CT4S cells. Development of a program of laryngoscopy, therapeutic bronchoscopy and endobronchial blocking techniques: a progress report. It is only when such measures fail that drug therapy should be considered. We examined 92 internal carotid arteries from 46 randomly chosen patients with suspected carotid stenosis by color-coded duplex ultrasound and by three-dimensional CT angiography (CTA).

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Magnetic resonance spectroscopy allows neurochemistry to be probed noninvasively in vivo. Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy. Among the BMP groups, the new bone formation was highest in the IrM and lowest in the IF radiographically, histologically and biochemically. Hepatitis E carries high morbidity and mortality in patients with underlying liver disease and can become a chronic infection that causes fibrosis in immunocompromised hosts. Most hemangioendotheliomas are low-grade vascular what is the best brand of tramadol neoplasms, with a tendency to recur locally and a low metastatic potential, mostly to regional lymph nodes.

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Whereas nonspecific DNA has no stabilizing effect, specific DNA induces tightening of the dimer and a 750-fold decrease in the K(d). A total of 87 patients were assigned to either early elective surgery (44 patients) or endoscopic biliary drainage followed by exploration (43). This study tested the feasibility of catheter ablation of poorly tolerated VTs by targeting a region identified during sinus rhythm. Here, we compared the effects of two atypical antipsychotics, paliperidone and aripiprazole, on cAMP/calcium signaling and prolactin release in female rat pituitary lactotrophs in vitro. The most widespread geometries produced by photolithography are thin-film microdisc electrode arrays with different electrode distributions (square, hexagonal, or random). All patients were examined first with high-definition endoscopy followed by pCLE at 7 standardized locations and endoscopic-suspected lesions.

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The psychological reactions after witnessing a killing in public in a Danish high school. It is characterized by the abrupt onset (no forewarning) of massive episodic memory impairment, both anterograde and retrograde. NPY Y5 receptor protein was measured in hippocampal homogenates using a specific polyclonal antibody and quantitative Western blotting. It is though to be important to follow up with special concern about possible dilation of sinus of Valsalva due to intrinsic weakness of the aortic wall. We then conducted genome-wide linkage analysis, and whole-exome sequencing was carried out with samples of two patients. Describe ankle injury epidemiology among US high school athletes in 20 what allergy medicine can i take with zyrtec sports. Three complete DHDPS coding sequences and one partial sequence were obtained in Medicago truncatula via inverse PCR. Platelet glycoprotein IIb/IIIa blockade and outcome of cardiogenic shock complicating acute coronary syndromes without persistent ST-segment elevation.

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We used brownian dynamics to study the peeling of a polymer molecule, represented by a freely jointed chain, from a frictionless surface in an implicit solvent with parameters representative of single-stranded DNA adsorbed on graphite. Clinical comparison of QUANTA Flash dsDNA chemiluminescent immunoassay with four current assays for the detection of anti-dsDNA autoantibodies. Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain. We show via a facilitated knockout approach that chromosomal CYP51 genes can only be knocked out in the presence of episomal complementation and that this episome cannot be lost from the parasite even under negative selection. The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation. Secondly, the notion of the work situation outlined by an organization specializing in work safety measures is used as a guide for transfer evaluation. These two suppressive mechanisms are controlled differentially by the nature of the STAT6 DNA-binding site (i.e. In situ hybridization studies showed the absence of TRbeta and that TRalpha1 and TRalpha2 colocalized in Sertoli cells of prepubertal testis, whereas germ and interstitial cells appeared devoid of TR mRNA signals. This study determined the histological features of the atrial myocardium connecting the coronary sinus and the left atrium in humans. The glutathione and thiol contents of fresh spleen T cells from LPS- and poly A:U-treated mice were significantly higher than control values.

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Post-processing was performed on an Aquarius Workstation (TeraRecon, San Mateo, Calif.). The practical value of the ultrasonic method, both in establishing diagnosis and in treatment, is emphasized. We show here that ectopic expression of hBH in 293APPwt and CHOAPPsw cells altered the processing of amyloid precursor protein (APP) and increased significantly the release of its proteolytic fragment, beta amyloid (Abeta). Incidence rates of specific histological types of lung cancer in Singapore Chinese dialect groups, and their aetiological significance. The tumor-suppressor protein phosphatase 2A (PP2A) belongs to the serine-threonine phosphatases family and accounts for the majority of serine-threonine phosphatase activity in eukaryotic cells.

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These drugs interact with numerous antihypertensive medications and tricyclic antidepressants. Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. Recent experimental evidence supports the role of glucocorticoids in the neuroendocrine control of food intake and energy expenditure. Furthermore, FGF-23 has emerged as a counter regulator of the renal 1alpha(OH)ase and sodium-phosphate cotransporter activities to modulate phosphate homeostasis. ASHP therapeutic position statement of optimizing treatment of hypertension. Quality of life and mood in women receiving extensive chemotherapy for gynecologic cancer. CoilA and CoilB showed to be effective in reducing the red blood cell lysis mediated by EHEC O157:H7 and the in vitro secretion of translocator proteins EspB and EspD by EHEC O157:H7 and EspD by C. FURTHER STUDIES ON THE GOITROGENIC ACTION OF THYROXINE ADMINISTERED WITH PROPYLTHIOURACIL, METHIMAZOLE OR PERCHLORATE.

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A phylogeny of the flowering plant family Apiaceae based on chloroplast DNA rpl16 and rpoC1 intron sequences: towards a suprageneric classification of subfamily Apioideae. Both the radioimmunoassay and measurements of plasma concentrations of methylmalonic acid were applied to the diagnosis of cobalt/vitamin B12 deficiency in sheep. Because many radiolucent foreign bodies have sufficient contrast for imaging in the optical domain, laser-induced optoacoustic imaging could be advantageous for the detection of such objects. In male mammals, the X and Y chromosomes are transcriptionally silenced in primary spermatocytes by meiotic sex chromosome inactivation (MSCI) and remain repressed for the duration of spermatogenesis. Privileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. Heme b containing chlorite dismutase (Cld) catalyses the conversion of chlorite to chloride and dioxygen which includes an unusual OO bond formation. The neutralisation of circulating ghrelin, the only known peripheral orexigenic peptide hormone, is a promising approach for the pharmacological treatment of obesity. Phase 1 and phase 2 studies of Salmonella enterica serovar paratyphi A O-specific polysaccharide-tetanus toxoid conjugates in adults, teenagers, and 2- to 4-year-old children in Vietnam. A residual foreign body should be seriously considered after neck trauma because it can result in a lethal hemorrhage originating from a delayed rupture of blood vessels. Quantitative Determination of Ciprofibrate in Tablets by Derivative UV Spectroscopy and RP-HPLC Method.

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The prosegment has a unique fold and inactivation mechanism that involves displacement of the catalytically essential His residue by a loop inserted into the active site. These investigations also suggest that the phonemic deficit resides in a different mode of speech perception which is based on allophonic (subphonemic) units rather than phonemic units. In this way, one stainless steel stent produced less intra-luminal hyposignal than a nitinol device. Red-blood-cell potassium as a practical index of potassium status in elderly patients. PW was applied at intensities between 0.1 W cm-2 and 0.77 W cm-2 (Isatp) and CW intensities were 0.1 W cm-2 or 0.5 W cm-2 (Isata). Methodology of calculation of the relationship concentration (dose) - time - effect of general toxic effect of xenobiotics on organism from the point of view of chemical and biologic kinetics. This may result from trandate dosing increased catabolism of precursors of proteins and nucleic acids as reflected by the more rapid breakdown of nitrogenous compounds.

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There was a significant reduction in pain and improvements in function and quality of life with custom-made laterally wedged insoles with arch support in older adults with mild-to-severe medial KOA. In the second cycle, mild ovarian hyperstimulation with 75 IU IM hMG was applied daily and ovulation was induced with 5,000 IU hCG. Multiple subfamilies of mariner transposable elements are present in stalk-eyed flies (Diptera: Diopsidae). A case of multiple metastatic giant rectal GIST successfully treated with surgical intervention after administration of imatinib mesylate. 63 ASA physical status I and II adult patients scheduled for elective orthopedic surgery. This stent system aims to provide both tactile and visual confirmation of the ostium at the aorta, allow for improved accuracy during stent positioning and placement, provide complete scaffolding of the lesion at the aortic junction to the native vessel, and enable future vessel reaccess.

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