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Benformin (Glibenclamide)

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Benformin is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Benformin tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Benformin, Betanase, Bionil, Codica, Combidos, Daocon, Daonil, Diabetrol, Diabnil, Diolin, Duotrol, Dutrol, Eumet, Glibenclamide, Glibson, Glifil, Glime, Glinil, Glitrac, Glucomin, Gluconil, Glucored, Glucosil, Glutowin, Glybonil, Glyboral, Glybovine, Glycurb, Glymep, Melitus, Metica, Monomet, Sugatrol, Sugnl, Sugronil, Symet, Triglucored

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Also known as: Glibenclamide


Benformin comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take Benformin twice a day. To help you remember to take Benformin, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Benformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Benformin and gradually increase your dose if needed. After you have taken Benformin for some time, Benformin may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Benformin helps control blood sugar but does not cure diabetes. Continue to take Benformin even if you feel well. Do not stop taking Benformin without talking to your doctor.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Benformin-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Benformin (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Benformin and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Benformin (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Benformin-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Benformin component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Benformin/metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benformin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Benformin if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking Benformin, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Benformin may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using Benformin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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Laryngeal cancers had a better prognosis than cancers of the oro- and nasopharynx. HL is unique as it consists of a small percentage of malignant cells (Hodgkin Reed Sternberg cells) surrounded by an inflammatory microenvironment which promotes tumor growth and suppresses immune responses, making it an ideal target for immunotherapeutic approaches, such as PD-1 inhibitors and cellular immunotherapy. Feasibility study of Flextube reflectometry for localisation of upper airway obstruction in obstructive sleep apnea. Out-of-hours specialist palliative care provision in an oncology centre: is it worthwhile?. The results of this survey will be pivotal in setting goals for a provincial gynaecologic oncology program. Meta-analyses describing the impact of various treatments allow the case manager to better prepare the patient and family for the healthcare issues the patient may face in recovering from a diagnosis and/or treatment. Periodontal disease is a significant cause of tooth loss among adults. Dysplasia expresses altered nuclear matrix protein composition in human ulcerative colitis. Newborns who had diabetic mothers and were exposed to repeated heel lances in the first 24 to 36 hours of life learned to anticipate pain and exhibited more intense pain responses during venipuncture than normal infants.

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