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Benformin (Glibenclamide)
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Benformin

Benformin is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Benformin tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Benformin, Betanase, Bionil, Codica, Combidos, Daocon, Daonil, Diabetrol, Diabnil, Diolin, Duotrol, Dutrol, Eumet, Glibenclamide, Glibson, Glifil, Glime, Glinil, Glitrac, Glucomin, Gluconil, Glucored, Glucosil, Glutowin, Glybonil, Glyboral, Glybovine, Glycurb, Glymep, Melitus, Metica, Monomet, Sugatrol, Sugnl, Sugronil, Symet, Triglucored

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Desyrel, Xanax, Cymbalta, Adalat, Rhinocort, Levaquin, Motrin, Ovral, Lasix, Avodart, Slimfast, Amlodac, Ultrazac, Altiazem, Alpose,

Also known as: Glibenclamide

Description

Benformin comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. However, in some cases your doctor may tell you to take Benformin twice a day. To help you remember to take Benformin, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Benformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of Benformin and gradually increase your dose if needed. After you have taken Benformin for some time, Benformin may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment.

Benformin helps control blood sugar but does not cure diabetes. Continue to take Benformin even if you feel well. Do not stop taking Benformin without talking to your doctor.

Dosage

Usual Adult Dose for Diabetes Type 2:

Doses provided as Benformin-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Benformin (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Benformin and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Benformin (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Benformin-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Benformin component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Benformin/metformin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Benformin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Benformin if you are allergic to it, or if:

you are being treated with bosentan (Tracleer); you have type 1 diabetes; or you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

hemolytic anemia (a lack of red blood cells); an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); a nerve disorder affecting bodily functions; liver or kidney disease; or an allergy to sulfa drugs.

Before taking Benformin, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.

Benformin may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Tell your doctor if you are pregnant or breastfeeding.

Follow your doctor's instructions about using Benformin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

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A review of child welfare research suggests that children of color and their families experience poorer outcomes and receive fewer services than their Caucasian counterparts. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. Peptide mass fingerprinting revealed that the peptides obtained show high homology to the other members of SVMP family. However, the reconstruction of accurate spatial images of brain activity from optical measurements represents an ill-posed and underdetermined problem that requires regularization. Development of adrenal cortical carcinoma in systemic lupus erythematosus: a case report. In the present study we set out to determine which domains of TAX-1 are involved in promoting the homophilic, adhesive properties of the molecule. With the increased knowledge obtained from more formal and rigorous clinical trails in recent years on the benefit of more intensive management of blood glucose and blood pressure in preventing or delaying the development and progression of diabetic micro- and macro-angiopathies, the challenges for routine clinical practice have become even greater.

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The strong and specific induction of osteopontin in direct response to increased phosphate levels provides a mechanism to explain how expression of this product is normally regulated in bone and suggests how it may become up-regulated in damaged tissue. Therefore, it becomes increasingly important to focus on how these differences are reflected in the structures, and how these structural differences are related to function. There was sustained control of malaria incidence during IRS implementation. Our knowledge about the cause of cerebral palsy continues to expand and prenatal events are thought to play an important role. The effects triggered by the formation of complex between zwitterion and sugar alcohol provide a simple and safe way to remove biofilms without antibiotics and physical forces. A total of 15 different protein peaks were identified between the lysate of H(22) cells treated with ATO and controls. Steroid hormones regulate synthesis of growth stimulatory and inhibitory growth factors, growth factor receptors, and growth factor binding proteins. Secular trend in stature in the Portuguese population (1904-2000). Spectrophotometric and spectrofluorimetric determination of certain diuretics through ternary complex formation with eosin and lead (II). International Commission for Protection Against Environmental Mutagens and Carcinogens.

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The blocking properties of TsTX-Kalpha in a mammalian cell line (L929), stably transfected to express Kv1.3, were studied using the patch-clamp technique. Multivariate analysis was used to adjust for various confounders. The retina at the macula thickens and this can cause gradual loss of central vision. In addition, immunocytochemical staining showed the co-expression of cytokeratin and neurofilament. This study reports the exposure and respiratory health of street cooks in Ile-Ife, Nigeria.

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Findings show that respondents are aware of recommendations for less frequent Pap testing, but they believe that women should generally receive annual Pap tests and that regular Pap testing should not be discontinued among the elderly. Impact of a physical activity program emphasizing cardiovascular fitness, muscle strength, and flexibility among middle-aged women. The signal is resynthesized by summing exponentially damped sinusoids at frequencies corresponding to peaks in the masked spectra. The application of phenomenology to psychiatry and psychotherapy. The net result is that (-)deprenyl inhibits the releasing effect of tyramine, and at present, is the only safe MAO inhibitor that can be administered without dietary precautions. Alcohol and substance misuse was chosen as a topic for its relevance to college students and health professionals. Half standard deviation estimate of the minimally important difference in HRQOL scores?. HGF treatment promoted the sphere-forming capacity of HNSCC stem-like cells and increased the expression of stem cell markers such as Oct4, Sox2, and CD44. To examine the behavior of Bcl-2 in normal cells, T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling. Prolonged anti-oestrogenic and anti-fertility actions of sometriarylalkenes.

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Prophylactic surgery was justified by the size and as judged by cross-sectional echocardiography of the vegetation and its morphology. Clinical application of genetic information to individual health care requires simple and rapid identification of nucleotide changes in clinical settings. Enhanced salt tolerance of transgenic poplar plants expressing a manganese superoxide dismutase from Tamarix androssowii. This phenomenon is possibly not directly related to the temperature-sensitive block. Within 48 hr a significant increase in the corticosterone concentration was observed in each species. The objective of this study was to compare pathological findings from PRIAS-eligible and PRIAS-ineligible clinically low-risk prostate cancer patients.

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Laryngeal cancers had a better prognosis than cancers of the oro- and nasopharynx. HL is unique as it consists of a small percentage of malignant cells (Hodgkin Reed Sternberg cells) surrounded by an inflammatory microenvironment which promotes tumor growth and suppresses immune responses, making it an ideal target for immunotherapeutic approaches, such as PD-1 inhibitors and cellular immunotherapy. Feasibility study of Flextube reflectometry for localisation of upper airway obstruction in obstructive sleep apnea. Out-of-hours specialist palliative care provision in an oncology centre: is it worthwhile?. The results of this survey will be pivotal in setting goals for a provincial gynaecologic oncology program. Meta-analyses describing the impact of various treatments allow the case manager to better prepare the patient and family for the healthcare issues the patient may face in recovering from a diagnosis and/or treatment. Periodontal disease is a significant cause of tooth loss among adults. Dysplasia expresses altered nuclear matrix protein composition in human ulcerative colitis. Newborns who had diabetic mothers and were exposed to repeated heel lances in the first 24 to 36 hours of life learned to anticipate pain and exhibited more intense pain responses during venipuncture than normal infants.

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We previously reported that glomerulonephritis associated with Staphylococcus aureus infection (SAGN) showed an increased usage of T cell receptor Vbeta 5.3 and 8 in peripheral lymphocytes and mesangial IgA and IgG depositions. An epidemiological study of fascioliasis and/or schistosomiasis was conducted in Abis 1 village. The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats. Genomic islands and the evolution of catabolic pathways in bacteria. Existing education materials could be adapted for use in the ED and to accommodate the training preferences of Australian and New Zealand ED staff. Effect of metoclopramide on fed-state gastric myoelectric and motor activity in dogs. Estimating the cost effectiveness of alternative drug treatments for postmenopausal osteoporosis. Population density was indexed as the density of pika latrine sites. Pharmacy benefit management contracting: an assessment from a recent public sector procurement experience. Clinical value of positron emission tomography with F-18-FDG in the follow up of patients with cancer of the ovary.

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