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Betrol (Glibenclamide)

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Betrol is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes. Betrol is in a class of medications called sulfonylureas.

Other names for this medication:
Benclamet, Comdiab, Daocon, Diabetnil, Diabetrol, Diabnil, Diolin, Duotrol, Euglucon, Giclamide, Glibact, Glibet, Glifil, Glinil, Glucomin, Gluconil, Glucosafe, Glunil, Glyboral, Glybovine, Iscept, Melitus, Metclam, Metica, Pionorm, Secrin, Sugatrol, Sugnil, Sugronil

Similar Products:
Furadantin, Nuvigil, Parlodel, Periactin, Xenical, Loxitane, Silagra, Zofran, Megestone, Glycomet, Peloscab, Lodales, Lostan,

Also known as: Glibenclamide


Betrol is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Betrol belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. Betrol, micronized may be used alone or with another oral medicine such as metformin.

Betrol, micronized is available only with your doctor's prescription.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Betrol-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Betrol (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Betrol and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Betrol (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Betrol-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Betrol component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Betrol/metformin dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Betrol overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Betrol dosage information

Side effects

The most common side effects associated with Betrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Betrol in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Betrol.

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