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Biolar (Lorazepam)

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Biolar is a drug used for treating anxiety. It is in the benzodiazepine family, the same family that includes Valium, Xanax, Klonopin, Dalmane, and others. It is thought that excessive activity of nerves in the brain may cause anxiety and other psychological disorders. Gamma-aminobutyric acid (GABA) is a neurotransmitter, a chemical that nerves in the brain use to send messages to one another. GABA reduces the activity of nerves in the brain. Biolar and other benzodiazepines may act by enhancing the effects of GABA in the brain. Because Biolar is removed from the blood more rapidly than many other benzodiazepines, there is less chance that Biolar concentrations in blood will reach high levels and become toxic. Biolar also has fewer interactions with other medications than most of the other benzodiazepines. The FDA approved Biolar in March 1999.

Other names for this medication:
Almazine, Anxilor, Anxionil, Anxipose, Atipam, Biokalm, Biolar, Calmese, Dulozep, Larosh, Larpose, Lopam, Lopez, Loracalm, Lorakar, Loralite, Lorazam, Lorazepam, Lorazine, Loricon, Loripam, Lorivan, Lorpam, Lorvin, Lotweet, Nexlor, Norpose, Olraz, Trapex, Urpam, Zelor, Zepatrac, Zepnap

Similar Products:
Maxalt, Zocor, Motilium, Xenical, Duricef, Famvir, Yasmin, Cetrose, Ezetrol, Periactin, Sayodol, Utamide, Rustin,

Also known as: Lorazepam


Biolar belongs to a class of medications called benzodiazepines. These medications work by boosting the activity of gamma-aminobutyric acid (GABA) within your body.

GABA is a neurotransmitter that transmits messages between cells in different parts of your body. Increasing GABA in the body results in a tranquilizing effect that reduces feelings of stress and anxiety.

How long does it take to work?

Benzodiazepines such as Biolar are categorized based on how fast they work. Biolar is classified as having a rapid to intermediate onset (start) of action. It begins to work right away after it’s taken, but its peak effect occurs within 1 to 1.5 hours.


When given intramuscularly, Biolar Injection, undiluted, should be injected deep in the muscle mass.

Injectable Biolar can be used with atropine sulfate, narcotic analgesics, other parenterally used analgesics, commonly used anesthetics, and muscle relaxants.

Immediately prior to intravenous use, Biolar Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. The rate of injection should not exceed 2.0 mg per minute.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if solution is discolored or contains a precipitate.

Biolar Injection is compatible for dilution purposes with the following solutions: Sterile Water for Injection, USP; Sodium Chloride Injection, USP; 5% Dextrose Injection, USP.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Biolar can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.


Store Ativan at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Biolar is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Side effects

The most common side effects associated with Biolar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid drinking alcohol within the first 1 or 2 days after you receive lorazepam injection. Dangerous side effects or death could occur.

Lorazepam can cause extreme drowsiness that may last for 24 to 48 hours after the injection. Older adults may feel sleepy for even longer.

Avoid driving or hazardous activity until the effects of lorazepam have worn off completely. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

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Through the implementation of the Omnibus Budget Reconciliation Act of 1990, considerable experience in ambulatory DUR programs has been achieved. The object of the study was the assessment of the mortality risk for persons with a mental disorder in an unselected representative community sample assessed longitudinally. Football, fast cars, and cheerleading: adolescent gender norms, 1978-1989. Our aim was to investigate whether the appearance of the proteolytic phenotype had any correlation with the expression of H-ras and nm23-H1 genes in carcinoma of the uterine cervix. Pro-inflammatory cytokines induce in vitro hyperresponsiveness in normal airway smooth muscle via a mechanism involving intracellular calcium mobilization. Prophylactic corticosteroids in singleton preterm pregnancies accelerate lung maturation and reduce the incidence of respiratory complications.

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The major drawback is the additional time needed for the interventional procedure, and the equipment and personnel requirements. Because high-flow nasal cannula presents some advantages, it may be used instead of NIV in obese patients after cardiothoracic surgery. A theoretical formalism is elaborated to determine the acoustic field scattered from a finite cylindrical shell reinforced by a set of ribs with internal axisymmetric oscillators, the locations and properties of which can vary arbitrarily along the cylinder axis. These effects of NO may result in impairment of cartilage repair, by interfering with the extracellular matrix regulation of chondrocyte function. These constraints can in turn be related to the generalized forces conjugate to the motion of grains rolling over each other. Quantities which sensitize with respect to these delayed type reactions do not induce antibody formation detectable by a sensitive hemagglutination. FeNO is higher for the acute onset than non-acute, which may be useful to evaluate the control degree. The two commonest surgical options are transection of the nervus intermedius, and microvascular decompression of the nerve at the nerve root entry zone of the brainstem. However vocational rehabilitation significantly improves these limitations, which in turn help these patients to integrate into the society so as to function efficiently in their roles as parents, home makers and social beings. In conclusion, DM aggravates brain damage in cirrhosis patients.

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Magnetic resonance imaging of the temporomandibular joint (TMJ) was performed on two normal volunteer subjects and two symptomatic subjects using a 0.15 T resistive magnet. Here, we provide a comprehensive study of several biofunctionalization methods, including the layer-by-layer technique and both the gas-phase and liquid-phase silanizations, and we propose a new maleimide-based protocol for grafting a protein to a sensor covered by alumina. The results indicate that Asp and Asn supplementation in rats with high glycogen concentrations (fed state) further increased the glycogen concentration in the muscle, and decreased in vitro 2-deoxyglucose (a glucose analog) uptake by the muscle at maximal insulin concentrations. Visible light-induced transition metal-catalyzed transformations: beyond conventional photosensitizers. In the first study the changes in the thiamine-dependent enzyme erythrocyte transketolase (TK) which followed the administration of oral thiamine are described. Isosafrole and safrole also prevented bromotrichloromethane (BrCCl3)-induced hepatocyte cytotoxicity, whereas PBO was ineffective. RYT had higher pH levels, electrical conductivity, and organic and ammonium nitrogen content than YT.

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The renal lesions characteristic of tuberous sclerosis are angiomyolipoma and cysts, with the former considered to be more common. Flow cytometric assay for the evaluation of phagocytosis and oxidative burst of polymorphonuclear leukocytes and monocytes in myelodysplastic disorders. Antisera raised against hemolymph proteins were also used to identify cross reactive antigens/epitopes present in other tissues by Western blotting, as well as by in vivo ELISA. This study explores the influence of individual factors and social support on traumatic reactions in firefighters exposed to tragic events in the line of duty. Factors affecting outcome in free-tissue transfer in the elderly. In some blood vessels efferent to the renal corpuscles, hydrostatic pressure may be as high as in the afferent supply. Rates of nearly all local and systemic reactions were significantly lower among the MPHBL group than the Lederle group. Other studies with older groups of persons are needed to examine the stability of scores. Pathological examination in each case revealed cavernous angioma.

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The hitherto obtained solutions for the replacement in diseases of kidneys, the heart, the lungs, the pancreas and the liver are developed in a different way. Instead, the data are most consistent with a pressure-linked increase in endothelial permeability to LDL. Cancer of the breast is the most common incident cancer and cause of death from cancer in women. Clinical trials of conjunctive anticoagulant strategies in thrombolysis. Baroreflex sensitivity and neurohormonal activation in patients with acute myocardial infarction. Neonatal outcome after indomethacin treatment for preterm labor.

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Coal dust explosions (CDE) are one of the main threats to the occupational safety of coal miners. The care of older persons with diabetes mellitus: families and primary care physicians. The 3.0 A crystal structure of the vitamin B(12) RNA aptamer revealed an unusual tertiary structure that is rich in novel RNA structural motifs. This report demonstrates the feasibility, demand, and effective synergy of integrating on-site primary care services into HIV VCT in Haiti. Further studies revealed that the effects of HG- and RGI-rich pectins were dependent on pretreatment, which caused alterations in cell morphologies such as cell size and shape, focal adhesion, and the organization of actin filaments, suggesting that HG and RGI pectins exert synergistic effects on cell migration, likely through different ways. Impacts of river bank erosion on population displacement in the lower Brahmaputra (Jamuna) floodplain.

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Dietary and activity habits and other life style components are assessed by questionnaires, prior to, during, and after training. This paper describes a case of occupational asthma caused by samba wood dust. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity. In revision total hip arthroplasty (THA), proximal femoral bone loss creates a challenge of achieving adequate stem fixation. They also were the commonest reasons for discontinuing treatment and reported as suspected ADRs. The cell death induced in a VR1-independent manner has the hallmark of apoptosis, whereas the cell death mediated by vanilloids binding to VR1 is seemingly necrotic. In intact transgenic animals expressing cameleons, fluorescence ratio changes accompanied muscular contraction, verifying detection of calcium transients.

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Especially in the field of anticancer therapy many efforts have been made to deliver drugs to specific tissues. Serum was assayed for nitric oxide (NO), lipid peroxidation, and antioxidant enzyme. Occurrence of diacylglyceryltrimethylhomoserines and major phospholipids in some plants. The limit of the method is mainly determined by the formation of adducts between triethylamine and some PL, namely, PE, monomethylphosphatidylethanolamine, phosphatidylethanolamine plasmalogens, and some lyso-PL. To assess the validity of a diagnostic protocol designed to predict the outcome of newborns of mothers suspected to have primary cytomegalovirus (CMV) infection during the first 4 months of pregnancy. Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface.

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To improve our understanding of the drought tolerance of the three common European temperate forest tree species Norway spruce, silver fir and common beech, we tested the influence of climate and tree-specific traits on the inter and intrasite variability in drought responses of these species. The temporal maturational changes in composition and structure of the mineral phase were difficult to assess because of the continuous deposition of crystals throughout culturing. Despite the regional nature of the PWVPWI measurements, as opposed to the global PWVtonometry measurements, abdominal PWVPWI and carotid-femoral PWVtonometry values were found to be similar, with an average bias equal to 0.25 m/s. As vaccination antigens should induce an appropriate mucosal IgA immune response against H. This is the first report of inducing HIV-1 Nef-specific cytotoxic T lymphocytes by DNA vaccine. To investigate whether or not the gamma-aminobutyric acid GABA receptor subtype Alpha genes GABRA5 and GABRB3 are associated with childhood absence epilepsy CAE . They exert multiple physiological effects on higher animals as immunoadjuvants, activators of macrophages, pyrogens, antitumor agents, inducers of contractility of smooth muscle, and promoters of slow-wave sleep, as well as nonspecific protectors of animals against infection. An incubation of the cells with 25 or 50 microm of CPt at 37 degrees C caused apoptosis, which progressively increased during the 24-72 h treatment. The study proposed a clinical decision rule: In patients who have taken a deliberate overdose, but deny taking paracetamol or paracetamol containing compounds, who have a GCS of 15, understand English well, and have not taken excessive alcohol, there is no need to take blood for paracetamol estimation.

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Terson syndrome in a course of cerebral aneurysm--clinical assessment. Seleno compounds and glutathione peroxidase catalyzed decomposition of S-nitrosothiols. To analyze the relationship between plasma level of cortistatin(CST) and coronary heart disease(CHD) and the factors that influence the level of CST. Insulin-like growth factor 1-induced alterations in lumbospinal monoamine dynamics. Attitudes are one of the most important outcomes of medical education, but little is known about curricular influences on specific attitudes. If Helicobacter pylori infection could be controlled through improved socio-economic standards and possible development of a vaccine, and if anti-inflammatory drugs devoid of gastric side effects can be developed, peptic ulcer may become a less important health problem in the future.

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The lethal effect of relative humidity on air-borne bacteria and viruses. Case managers using the PBI can determine specific problem behavior areas among client populations and for individual clients and institute client-specific interventions to address each issue. These findings provide evidence that the renatured recombinant extracellular domain of mouse epidermal growth factor receptor is immunogenetic and may be important for further application of this protein in functional and immunological research. Changes in thyroid status of rats after prolonged exposure to low dose dichlorodiphenyltrichloroethane. The importance of the knowledge of clinical features, a course of nephropathy for early recognition of tumors and correct therapeutic tactics was discussed. A method of taking into account the inhomogeneity backscatter contribution to the Batho correction factor. Consequently, a full understanding of the evolution of antibiotic resistance requires the study of natural environments as well as clinical ecosystems. Since this modification occurs in the complementarity determining region (CDR) it was found that binding is reduced. In cultured neonatal rat cardiomyocytes, transduction with a recombinant adenoviral vector expressing p35 (Ad2/CMVp35) but not a control adenoviral vector expressing no transgene (Ad2/CMVEV) significantly inhibited doxorubicin-induced increase in cellular reactive oxygen species (ROS), the activity of caspases 8 and 3, cytochrome c release, and apoptosis. The mass of the muscles influences both the resonant frequency and the damping.

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This study was commissioned on behalf of the Faculty of Pre-hospital Care at the Royal College of Surgeons of Edinburgh, to examine the handling of patients on spinal boards on arrival in the emergency department what happens if you drink alcohol with zyrtec . Adhesion molecules in primary biliary cirrhosis and primary sclerosing cholangitis. 14-3-3 proteins regulate a wide range of target proteins via direct protein-protein interactions. Instead of the conventional methods of immobilization including plaster cast or internal fixation we think that the use of the external fixation is highly satisfactory, providing an excellent method of immobilization and allowing an early weight-bearing gait. Little is known regarding the extent to which patient-reported health status, including symptom burden, physical limitation, and quality of life, is determined by psychosocial vs physiological factors among patients with chronic disease. To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner.

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High resolution DNA fiber-fish on yeast artificial chromosomes: direct visualization of DNA replication. Measurement of glenohumeral joint motion has, for the most part, been performed with the simple goniometer. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Since time immemorial, it has been of interest why children are able to acquire language so easily. These encouraging results with treatment of only one lung will be built on with both sequential lung and simultaneous, bilateral lung treatment protocols. In this review of 105 consecutive patients who underwent operation for previously untreated, N0 squamous carcinomas arising in the oral tongue or the floor of the mouth, 86 percent of the determinate patients remained alive and well 2 years after treatment. We show that beta recombinase binds sequentially to both sites, having a different affinity for each one. The negative enhancement of normal renal tissue seen in intermediate-weighted fast inversion-recovery MR imaging is caused by T2 shortening at high gadolinium concentrations. Screening for chronic obstructive pulmonary disease using spirometry: recommendation statement. Exogenous neutral (N) and acidic (A) SMase activated NF-kappa B with different kinetics, accounting for the diverse pattern of DNA binding of NF-kappa B complexes activated by tumor necrosis factor-alpha (TNF).

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Previous educational and behavioral interventions in type 2 diabetes have produced modest improvements in glycemic control. The visual properties of nLM cells recorded in vitro were very similar to those that were recorded in intact turtles.(ABSTRACT TRUNCATED AT 400 WORDS). The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. This research focuses on the effects of transients in porewater chemistry on colloid mobilization within water-saturated porous media. Nuclear run-off experiments were used to show that castration of the adult resulted in a 3-fold decrease in total transcription activity. Calcium phosphate pellets wrapped in BMSC sheets regenerated a bone-like tissue, but pellets lacking the cell sheet wrap did not. Younger patients had significantly lower mean ratings for constipation and dry mouth. Barriers and solutions to fieldwork rotations in hand therapy are examined, as well as proposed solutions, including recommendations for student preparation.

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Transcriptional studies indicated that RON activation inhibits LPS-induced luciferase activity driven by the Cox-2 gene promoter. Magnitude of reactive thrombocytosis and associated clinical conditions in dogs. Due to the failure, to this day, to effectively and ubiquity prevent and revert these diseases, the research into new compounds and therapeutic strategies is vital. New genes generated by retroposition are widespread in humans and other mammalian species. although respondents described symptoms as the main reason for the call, they also described a range of other factors that led to the call, including their feelings, concerns about specific illnesses, their responsibility for others, and their previous attempts to manage the problem themselves. Impact of changes in asthma severity on health-related quality of life in pediatric and adult asthma patients: results from the asthma outcomes monitoring system.

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We confirmed that the swollen ciliary body with anterior rotation and supraciliary space caused transient angle-closure glaucoma in this patient with Vogt-Koyanagi-Harada syndrome. The most interesting result of analysis of B12 elements is that B12-independent isozymes of the methionine synthase and ribonucleotide reductase are regulated by B12 elements in bacteria that have both B12-dependent and B12-independent isozymes. Several genes had been identified to be associated with the pathogenesis of dextro-transposition of the great arteries (d-TGA). A specific statute governing assisted reproduction is one way vasotec iv dosing to regulate assisted reproduction. Rpf is required to resuscitate the growth of dormant Micrococcus luteus organisms, and its homologues may be involved in mycobacterial reactivation. These differences persisted after adjusting for baseline differences in client characteristics. Report on a meeting of a Regional Working Group on Psychosocial Aspects of Voluntary and Involuntary Childlessness, held in London (UK) on 10-12 December 1979. These results strongly suggest that glucocorticoids do not have a significant role in mediating the LPS-induced acute suppression of pulsatile LH secretion in orchidectomized rats.

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Dysfunctional attitudes may be a risk factor for the onset (but not the outcome) of episodes of moderately severe, typically comorbid, anxiety and depression found in primary care settings. The immunoreactive material was localized on the granular cores and diffusely in the axoplasm in both nerves. Veterans with PSUD have more severe problems along several dimensions and use more numerous and varied services than cefpodoxime brand name those with 1 SUD. However, the effects of regression to the mean will confound a simple analysis of the repeated measurements obtained before and after the cross-over. Consequently, three DEGs, LRAT, SLC7A11, and ITGA2, were selected for further analysis. The aim of this study was to determine the clinical significance of the preoperative serum CRP level in patients with stage IV colorectal cancer.

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Virus culture was by the HEP-2 culture technique capable of detecting both herpes simplex Type 1 and herpes simplex Type 2. By observing the relationship between the receptive field sizes of the different layers in the network and the skeleton scales they can capture, we introduce two scale-associated side outputs to each stage of the network. Improved light collection and wavelet de-noising enable quantification of cerebral blood flow and oxygen metabolism by a low-cost, off-the-shelf spectrometer. Ring fission of this latter compound gave maleylacetoacetate which was isomerized to fumarylacetoacetate. This study investigated cyanotoxin release and elimination through different treatment trains in systematic pilot-scale studies with water from the Weida Reservoir, in Thuringia, Germany. In contrast, p18 protein increased 50-fold, from negligible levels in proliferating myoblasts to clearly detectable levels within 8-12 h of myogenic induction. Development of object permanence in food-storing magpies (Pica pica). These observations provide groundwork for future studies to examine the role of EGF-induced kinase cascades and transcription factors in zyrtec dose by weight liver regeneration and other growth factor-mediated hepatic processes. Lack of limb proprioceptive signals in an aquatic environment is thus the element, which links the Xenopus model with human scoliosis because a comparable situation occurs during gestation in utero. The predictive power of sIL-6R levels on outcome is also unknown in this patient population.

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Distribution and maturation of catecholaminergic (CA) neurons have been studied by tyrosine hydroxylase immunohistochemistry in the medulla oblongata of human fetuses aged 14.5-25 weeks of gestation. Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands. MTT assay was carried out to investigate the cytotoxic effect of what to do if you miss a lexapro pill herb extract on PAE cells. The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice. The present data give some support for a negative association between exposure to persistent organochlorine compounds and fertility among heavy smokers. Increase of high molecular weight fibrinogen after surgery for renal cancer. The aim of the study was to detect the number of latently infected cells with wild type virus and with mutant with reduced reactivation.

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We propose an effective range-separation of the coupling between the atomic response functions that extends the already broad applicability of the MBD method to non-metallic materials with highly anisotropic responses, such as layered nanostructures. Malaria, a parasitic infection transmitted by mosquitoes, is one of the most devastating infectious diseases, killing more than 1 million people annually. Immunoferritin study of the distribution of HL-A antigens on human blood cells. Small but significant effects of ethanol and its metabolite acetaldehyde on latent and free muscle protease activity were demonstrated. Stable cell lines were established by transformation of Sf9 cells with the expression vector pIEK1. Sequence similarity searching is an important and challenging task in molecular biology and next-generation sequencing should glucophage xr 500 dosage further strengthen the need for faster algorithms to process such vast amounts of data. 320 microm below the mean retina height), the interindividual variability of optic disc topography (oblique insertion, glaucomatous surface flattening) is respected at the cost of the need for an accurate optic disc border outline. In this review, we present structure and tissue distribution of PPAR nuclear receptors, discuss the mechanisms of action and regulation, and summarize the rapid progress made in this area of study and its impact on the cardiovascular system.

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Effect of high temperature in vitro on specific activity of beta-adrenoreceptors. Prenatal diagnosis of fetal cytomegalovirus infection in seropositive pregnant women. Ensuring that women choosing long-acting and permanent contraceptive methods are able to obtain either them or interim methods is essential. Self-help delivered with four sessions of face-to-face guidance led to improved outcome over 4 months. Tissue glucose transport and glucose transporters in suckling rats with endotoxic shock. To analyze the role of various elements comprising the lytic replicon, we assessed the ability of a wild type replicon to complement a defective replicon that contains a transposon inserted between an essential lytic replication gene (repL) and the promoter (P53) at which transcription of that gene is initiated. Morphine is typically given by intramuscular or intravenous injection but there are theoretical advantages for the subcutaneous route of administration.

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