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Bionil (Glibenclamide)

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Bionil is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Bionil tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Aviglen, Benclamet, Benformin, Comdiab, Daocon, Diolin, Dutrol, Euglucon, Eumet, Glibact, Glibet, Glibson, Glifil, Glinil, Glitrac, Glucomin, Glucored, Glucosafe, Glucosil, Glucotrac, Glutowin, Glybenclamide, Glybid, Iscept, Melitus, Metica, Monomet, Pionorm, Sugatrol, Sugnil, Sugronil, Triglucored

Similar Products:
Starlix, Zyvox, Nexium, Panadol, Micardis, Ceclor, Geodon, Hytrin, Zithromax, Flonase, Monic, Starval, Valric, Veromon, Ramifin,

Also known as: Glibenclamide


Bionil is used to treat high blood sugar levels caused by a type of diabetes mellitus (sugar diabetes) called type 2 diabetes. In type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your bloodstream. Chronic high blood sugar can lead to serious health problems in the future.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Bionil belongs to a class of medicines called sulfonylureas. It causes your pancreas to release more insulin into the blood stream. This medicine may be used alone or with another oral medicine such as metformin.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

Side effects

The most common side effects associated with Bionil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Bionil in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving Bionil.

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Seventy consecutive patients aged 6-49 y with CF were investigated using dual X-ray absorptiometry and the findings related to anthropometric data. This response was virtually absent in cultures of cerebellar neurons from transgenic mice expressing a dominant-negative form of the FGFR1. We conclude from these data that the inhibitory effect of heparin on SMC migration induced by thrombin relies, at least in part, on a blockade of HB-EGF-mediated EGFR transactivation. However, Tax stimulates CREB binding to a consensus CRE in the context of the 21-bp repeats, indicating the importance of these sequences in stimulating CREB binding. Facile Synthesis of Phosphono-Substituted Heterocyclic Compounds. Metastatic follicular thyroid carcinoma to the mandible: a case report. Activity experiments suggested that the presence of cellulose binding domains (CBDs) is not essential for cellulase performance in the textile processes, where high levels of mechanical agitation are applied. However, the role of innervation in adult myogenesis is unclear. Despite their versatility, however, peptides tend to display unfavourable pharmacological properties, such as low bioavailability, high renal clearance and proteolytic degradation rates, and low cell permeability.

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To investigate changes in atrial natriuretic peptide (ANP) and angiotensin II (AT-II) levels in a canine model of pulmonary embolism (PE), created by embolizing the left posterior pulmonary artery with gelatin powder. Modulation of the background variation, the starting concentrations, and the cutoffs enabled identification of criteria that were robust against false-positive signals of progression. Based on the advanced 3D structural design, the maximum peak power density of 3D textile can reach 263.36 mW m-2 under the tapping frequency of 3 Hz, which is several times more than that of conventional 2D textile TENGs. Models explaining how GcvR and GcvA might interact to regulate gcv expression are proposed. We investigated gene expression and cellular localization of NADPH oxidase isoforms in ULTR cells and confirmed expression of NOX1, NOX4, and NOX5 in myometrial tissue. Significant advances in water treatment over the last century have resulted in massive improvements in the microbiological safety of public drinking water supplies in the UK and the developed countries. Erika sisters in Hamburg - the development of an urban sisterhood at the end of the 19th century: soon responsibility for nursing in public hospitals was added. Gene expression analysis of microarrays of CAF and paired NCF populations enabled us to identify 108 deregulated genes (38 upregulated and 70 downregulated genes). In other words, contractility can best be conceived of as the calcium-contractile protein interaction. Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.

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Serological evidence of chronic infection with C pneumoniae is associated with risk of ischemic stroke in an urban, multi-ethnic population. The aim of this study was to determine the changes in sympathetic nerve activity (SNA) after atrioventricular junction (AVJ) ablation in patients with chronic atrial fibrillation (AF). On the other hand, certain types of amyloid aggregates revealed surprisingly strong VCD spectra with the sign and shape dependent on the conditions of fibrillation. Further longitudinal studies in this population are needed to confirm the associations. To evaluate the influence of hamstring tendon harvest on knee flexion strength in patients undergoing anterior cruciate ligament reconstruction.

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Expansion of EBV latent membrane protein 2a specific cytotoxic T cells for the adoptive immunotherapy of EBV latency type 2 malignancies: influence of recombinant IL12 and IL15. We consider catheter debanding a valuable alternative in selected cases. We report the cases of two male preterm newborns with X-linked centronuclear myopathy (CNM). Beta 1 and beta 2 integrins as well as Platelet-Endothelial Cell Adhesion Molecule-1 (PECAM-1) have been shown to be involved in transmigration. Effect of glycosylation and glucose trimming inhibitors on the influenza A virus glycoproteins. These contaminated wounds were then covered either with musculocutaneous flaps, random flaps, or left uncovered as a control. Purified FSH yields similar clinical outcome to hMG in terms of oocytes retrieved and clinical pregnancies in a standard IVF regimen. Compared to the controls, examinees with SX had signs of hyperinsulinemia, high levels of LDLP cholesterol, VLDLP cholesterol, is it safe to take zyrtec and cold medicine atherogenic index, packed cell volume, fibrinogen and platelet aggregation.

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Laminar distribution of neocortical senile plaques in senile dementia of the Alzheimer type. Among dyspneic patients with and without acute heart failure, sST2 concentrations are associated with prevalent cardiac abnormalities on echocardiography, a more decompensated hemodynamic profile and are associated with long-term mortality, independent of echocardiographic, clinical, or other biochemical markers of risk. The role of prometrium generic side effects high-affinity transporter, Pho84, in sensing and signalling of phosphate has also been discussed. A patient was a 65-year-old female who had a complaint of palpitation was diagnosed aortic valve stenosis due to congenital bicuspid aortic valve with pseudotendon by the echocardiographic examination. During the 8 yrs there was a steady increase in the number of admissions and a steady reduction in the length of stay. This problem can be finessed using empirical Bayes in which prior variances are estimated from the data, under some simple assumptions about their form.

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Effect of intramuscularly injected polyprenols on influenza virus infection in mice. Computed tomography enterography (CTE) showed tortuous thread-like calcifications in the ileocolic vein and right colic vein, while colonoscopy revealed purple-blue mucosa extending from the cecum to the splenic flexure. However, the idea that a cardiovascular component may be involved in human skeletal muscle stretching is relatively new. A randomised prospective study of patients presenting for elective inguinal hernia repair. Amiodarone seems to be a promising candidate, but only few randomized trials are available and the results are inconsistent. Gastro-intestinal manifestations of the initial phase of schistosomiasis mansoni.

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Relationship between head and neck squamous cell carcinomas and fibrinolytic factors. Sequence analysis and genetic mapping of porcine chromosome 11 centromeric S0048 marker. Our previous work genetically linked, for the first claritin d dosing time, PHMs to alternative polyadenylation and established EDM2 as a critical component mediating PHM-dependent polyadenylation control. Mycotic aneurysm of dorsalis pedis artery due to recurrent Candida albicans foot infection. The dorsalized phenotype could be rescued by the ventral specifying factor, BMP4. Dyspnea evaluation should be considered for all clinical practice guidelines and care pathways. ROP6 directly binds and activates MT-associated RIC1 to achieve the MT ordering. The arrival times for fall-out in each area of the scale are fixed, whatever the energy of the explosion and the speed of the wind might be. Class I suppressors were partial deletions of Mu insertion sequences in the disrupted chromosomal motA gene. The main outcome measures were duration and complications of pregnancy, mode of delivery, complications during and after childbirth, birthweight, Apgar score, and congenital anomalies.

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