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Cardizem (Diltiazem)

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Cardizem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolarization.

Other names for this medication:
Altiazem, Angizem, Cardem, Cardiorex, Cartia, Coriem, Dicard, Dilacor, Dilcardia, Dilcontin, Dilcor, Dilgard, Dilocor, Dilter, Diltia, Diltiaz, Diltiazem, Dilticard, Diltime, Diltp, Dilzem, Heartil, Icidil, Ionozem, Kaizem, Masdil, Onzem, Taztia, Tiamate, Tiazac

Similar Products:
Sporanox, Mysoline, Estrace, Persantine, Lanoxin, Glucophage, Imuran, Xanax, Panadol, Nuvigil, Zoamco, Estilo, Quinabic, Eliwel, Gabina,

Also known as: Diltiazem


Cardizem (diltiazem) is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.

Cardizem is used to treat hypertension (high blood pressure). It may be used alone or in combination with other high blood pressure medications.

Cardizem is also used to treat chronic stable angina (chest pain) and angina due to coronary artery spasm.


This section provides information on the proper use of a number of products that contain diltiazem. It may not be specific to Cardizem CD. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended-release tablet, extended-release capsule, or tablet whole. Do not open, crush, or chew it. It is best to take the extended-release capsule on an empty stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 120 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 milligrams (mg) once a day, either in the morning or evening. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 30 milligrams (mg) four times a day before meals and at bedtime. Your doctor may increase your dose if needed. Children—Use and dose must be determined by your doctor.

For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 180 to 240 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 180 to 240 milligrams (mg) once a day, either in the morning or at bedtime. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.

Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Cardizem LA dosage information

Side effects

The most common side effects associated with Cardizem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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To estimate age-specific prevalence of disability in activities of daily living for older Canadians, including the oldest old, those aged 90 and older. Diversity and the origin of the European population of Triticum dicoccum (Schrank) Schuebl. Our results show the differential proteomic profile of serum exosomes of patients with Kawasaki disease before and after intravenous immunoglobulin therapy, such as complement C3, apolipoprotein A-IV, and insulin-like growth factor-binding protein complex acid labile subunit. Saphenous vein graft chronic total occlusion interventions, a path less traveled, a frontier to be mostly avoided. Furthermore, we demonstrate that a strain deleted for the SKN7 gene and containing a temperature-sensitive mutation in Hsf1 is hypersensitive to oxidative stress. Postoperative stress reaction with respect to relative adrenocortical insufficiency in comparison with standard behavior. Nonprotein-bound iron in postasphyxial reperfusion injury of the newborn.

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Effects of cancer-testis antigen, TFDP3, on cell cycle regulation and its mechanism in L-02 and HepG2 cell lines in vitro. Experiment and calculations show good agreement and indicate that BANG polymer gels might become a valuable tool in proton therapy quality assurance. To determine whether adolescent smoking behaviour is associated with their perceived exposure to teachers or other pupils smoking at school, after adjustment for exposure to smoking at home, in school, and best friends smoking. Our aim was to validate a treatment approach with the objective of decreasing ERCP related adverse events (AEs). Although both groups suffered an increase in oxidative stress after CPB, this increase was higher in coronary revascularization group and therefore the possibility of post-CPB complications could be more severe in this group. In conclusion, this case highlights that chromosome 17p is genetically relatively instable, and thus it can lead to rare chromosomal conditions.

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Surgical management of recurrent urinary tract infections: a review. Modelling landscape dynamics with LST in protected areas of Western Ghats, Karnataka. We compared data between type 1 and type 2 diabetics and contrasted the amalgamated data with that of a matched control population of medical out patients using Students t tests. Localised corneal amyloidosis associated with herpetic keratitis. Decolorization of textile wastewater by photo-fenton oxidation technology. Three-loop corrections to hyperfine splitting in muonium, generated by the gauge-invariant sets of diagrams with muon and tauon loop light-by-light scattering blocks, are calculated. This method is not invasive for patients, and it is technically easy to execute.Oxidative stress monitoring is useful and may prove valuable for clarifying the pathophysiology of neuroemergency diseases, which has long been hampered by technical difficulties in measuring and monitoring oxidative stress.

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Conscious or deep sedation: a questionnaire regarding the experience of parents, children and staff during small bowel biopsy. These data strongly support the feasibility of development of intranasal vaccines with an enhanced protective efficacy against meningococci and possibly against other encapsulated bacteria. Agreement between total corneal astigmatism calculated by vector summation and total corneal astigmatism measured by ray tracing using Galilei double Scheimpflug analyzer. It also considers the implications of introducing exogenous genetic material into an oocyte via intracytoplasmic sperm injection (ICSI) and the possible implications of this for assisted reproduction. Diagnostic potential of virtual bronchoscopy: advantages in comparison with axial CT slices, MPR and mIP?. It is not known whether severe deficiencies are prevented by standard multivitamin supplementation and what parameters are influenced by patient adherence to nutritional care. Genetics of audiogenic seizures in mice: a parable for psychiatrists. Our finding that S100A7/psoriasin regulates differentiation and strengthens TJ barrier function provides novel evidence that, in addition to antimicrobial and immunoregulatory activities, S100A7/psoriasin is involved in skin innate immunity. The rate of increase after age 30 for each of the small chromosomes (groups D-G) was similar, with the exception of chromosome 16, which showed a significantly shallower rate. At present it seems clear that the surgery of epilepsy is used less than it could be.

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In vitro inhibition of prostaglandin biosynthesis by essential oils and phenolic compounds. The ability of these flavonoids to bind to thrombin receptors was investigated by competitive radioligand binding assays using (125 protonix dosage pediatric )I-thrombin. Microparticles made of low molecular weight polyesters were incubated with human macrophages and coronary artery endothelial cells (ECs). We describe the case of a young woman who presented with what was initially thought to be advanced ovarian cancer but who had tuberculosis of the peritoneum, uterus, and ovaries discovered at laparotomy. Antiapoptotic effect of nicorandil mediated by mitochondrial atp-sensitive potassium channels in cultured cardiac myocytes.

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Insulin-degrading enzyme (IDE), a 110-kDa metalloendopeptidase, hydrolyzes several physiologically relevant peptides, including insulin and amyloid-beta (Abeta). External validation of the interpretation of the 3D-QSAR model was derived from a response-independent procedure such as principal components analysis (PCA). Postoperative pain in total knee arthroplasty is a challenge that affects the facets of an optimal recovery process. We evaluated sublethal effects on blood meal ingestion and moulting. The study group comprised 242 eyes and included 118 virgin right eyes and 124 virgin left eyes of 155 individuals. We hypothesize that HSV-1 infection induces the formation of nuclear protein quality control centers to remodel or degrade aberrant nuclear proteins that would otherwise interfere with productive infection.

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The patient group, as compared with healthy controls, showed significantly enhanced amplitudes of P600 at the right temporoparietal area and prolonged latencies at the right parietal region. The effects of a photoperiod reduction in the entrainment of circadian rhythms of systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and spontaneous locomotor activity (SLA) were determined in conscious Wistar rats by using radiotelemetry. is examined, and it is suggested that the essential problem is not the character and habits of poor women but the persistence of poverty as a fundamental structure of the society. Experimental data are described in the paper, which demonstrate the possibility of a simultaneous extraction of acid and basic substances and of ampholytes from biological liquid for their subsequent gas-chromatography screening by means of a mass-selective detector. A review of the past and current status of the evolving field of spine oncology. The literature regarding the gynecologic effects of tamoxifen contains very little data on the vagina and lower urinary tract. This study describes the development of a growth hormone (GH) radioimmunoassay (RIA) using chum salmon (Oncorhynchus keta) GH and an antiserum raised against this preparation. As previously demonstrated in human myometrial cells, the cytoplasmic foci may correspond to centrosomes. Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement. Surface roughness and prometrium 200 mg benefits adsorptive coupling have only minor effects on macrophage activation.

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Studies on the glucose, fructose and saccharose content of various fruits. This X-linked or autosomal recessive trait may be a new entity, to be differentiated from other genetic lymphoedema syndromes, the so-called familial protein-losing enteropathy, and dominantly inherited intestinal lymphangiectasia. Maternal vitamin D deficiency had no effect on cardiomyocyte number, cardiomyocyte area, or the amaryl dosage proportion of mononucleated/binucleated cardiomyocytes in 3-day-old male and female offspring. Bone loss seems to be accelerated in untreated primary hyperparathyroidism. Urine cytology revealed many clusters of malignant cells suggestive of adenocarcinoma.

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A fatal case of cerebellar hypoplasia associated with anterior horn cell disease. Searches were conducted using MEDLINE (1946-August 2016), the Cochrane Library Database, clinical trial registries, and related reference lists. AIDS is causing increased stress on fragile African economic infrastructures as labor productivity declines, particularly in agricultural, labor-dependent economies. Selected strains (2.45, FSM 293, ATCC-12868, FSM-271) screened from 68 strains of Cronobacter spp. Current evidence indicates that tender points are not unique to fibromyalgia and are simply regions in the body where all people are more tender. We analyzed papers that were observational, models or that combined the two approaches. Importantly, we provided a guideline to construct libraries of frozen tissue with minimal effort, cost and space. Importantly, the mucosal vaccination, but not the conventional parenteral vaccination, induced bactericidal antibodies at the mucosal level. Imaging of choroid plexus infection by Stomatococcus mucilaginosus in neutropenic patients.

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The purpose of this study was to assess the feasibility and characterize the pharmacokinetics of squalamine administered as a continuous i.v. The modulation of protein A-IgG(Fc) binding by the reversible addition of 2-nitrobenzyl groups. From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. In an era when essentially no congenital heart defect is considered inoperable, it is reasonable to carefully consider the essentials of neonatal myocardial physiology and biochemistry, especially comparisons between immature and adult myocardial responses to ischemia. Arterial hypotension during stress echocardiography with Dobutamine (ESD) is an occasional complication with no prognostic value, but it sometimes necessitates termination of the investigation. In situ remediation strategies are an alternative approach in the management of radioactive contaminated areas, especially when based on modification of soil properties by the addition of amendments. The strongest predictors of cognitive impairment were age and timing of the test after operation. Mesenchymal stem cells (MSCs), a subpopulation of adult somatic stem cells, are an attractive stem cell source in regenerative medicine because of their multipotentiality. Elevated resting heart rate (RHR) or resting pulse rate (RPR) is associated with increased risk of hypertension development.

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