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Cytoxan (Cyclophosphamide)
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Cytoxan

Cytoxan is a nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma. Cytoxan is a fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45°C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.

Other names for this medication:
Cyclomet, Cyclophosphamide, Cycloxan, Cycram, Cycrame, Cydoxan, Cyphos, Eldamide, Endoxan, Ledoxan, Neophos, Neosar, Oncomide, Oncophos, Oncoxan

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Also known as: Cyclophosphamide

Description

Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by cyclophosphamide, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with cyclophosphamide, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain cyclophosphamide. It may not be specific to Cytoxan. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your doctor to help you plan a way to remember to take your medicines at the right times.

While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. Also, empty your bladder frequently, including at least once during the night. This will help prevent kidney and bladder problems and keep your kidneys working well. Cyclophosphamide passes from the body in the urine. If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. Follow your doctor's instructions carefully about how much fluid to drink every day. Some patients may have to drink up to 7 to 12 cups (3 quarts) of fluid a day.

Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. However, your doctor may want you to take it with food in smaller doses over the day, to lessen stomach upset or help the medicine work better. Follow your doctor's instructions carefully about when to take cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and loss of appetite. However, it is very important that you continue to use the medicine even if you begin to feel ill. Do not stop taking this medicine without first checking with your doctor. Ask your doctor for ways to lessen these effects.

If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets): For the treatment of cancer: Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 milligrams (mg) per kilogram (kg) of body weight per day. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 1 to 5 mg per kg of body weight per day.

Overdose

If you overdose Cytoxan and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Cytoxan dosage information

Side effects

The most common side effects associated with Cytoxan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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In the human neocortex with normal appearance, we identified the same local neuronal circuitry as in the normal monkey cortex, but in some regions of the same cortex, a fine disorganization of neuronal circuits (loss of inhibitory neurons and presumptive thalamocortical terminals) was found. In cases where radon data were available during the exposure period of the volume trap, a remarkable agreement was found. Using longitudinal surveys, we assessed the experience of clinicians and staff in 296 clinical sites that participated in the Centers for Medicare and Medicaid Services (CMS) Federally Qualified Health Center (FQHC) Advanced Primary Care Practice Demonstration. They normally appear in an invaginated area of the perikaryon in the proximity of large numbers of synapsis buttons, and often close to unfenestrated capillaries. A phenomenological model for mechanically mediated growth, remodeling, damage, and plasticity of gel-derived tissue engineered blood vessels. Alpha-particle-induced osteosarcoma in the mouse has been adopted as a model of human radiation carcinogenesis, and genome-wide screens have been conducted for allelic imbalance and genetic linkage. Contribution to the factors involved in the protective effect of ischemic preconditioning. These data support a hypothesis that metabolic conversion of homocysteine to thiolactone and protein homocysteinylation by thiolactone may play a role in homocysteine-induced vascular damage.

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Health related quality of life of donors was not compromised after full recovery. The authors will also provide us with some new approaches and methodologies that we can apply to the study of mosquito physiology and behaviour. These data demonstrate that the neurotrophin receptor trkB undergoes phosphorylation in the mossy fiber pathway and CA3 stratum oriens of the hippocampus during limbic epileptogenesis. Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C. The transition through a merger of two residency programs is difficult and has direct educational and emotional impact. This has not yet been attempted in youth, but has already been attempted in Australian adults.

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Respiratory motor responses to cranial nerve afferent stimulation in rats. Transfection of embryonal carcinoma (EC) cells with the plasmid resulted in significant cellular apoptosis and elevated expression of death receptor 4 (DR4) and death receptor 5 (DR5). During exercise, individuals require 200 to 800 mL/hour of liquid that should contain 20 to 30 mEq/L of sodium. To investigate the role of granulocyte elastase in ischemia/reperfusion injury of liver, the effect of ONO-5046, a granulocyte elastase inhibitor, was examined in ischemia/reperfusion-induced liver injury in rats. A sample of six probable fragmentary ankylosaur ossicles, collected from Cenomanian deposits of the Dunvegan Formation along the Peace River, represent one of the first dinosaurian skeletal fossils reported from pre-Santonian deposits in Alberta. Larger mask intensities increased masking only at very short ISIs, and longer mask durations increased backward but not forward masking. Small GTPase Rab5 is a multifunctional protein, which regulates early steps of endocytosis, due to its interactions with numerous effectors such as: Rabaptin-5/Rabex-5, EEA1, phosphatidylinositol 3-kinases hVPS34-p150 and p110beta-p85alpha, phosphatidylinositol 4- and 5-phosphatases, Rabenosyn-5/hVPS45, Rabankyrin-5, Huntingtin-HAP40, APPL1 and APPL2.

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Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide or prostacyclin. Their management is often extremely complex and experience with large numbers is restricted to a few centres worldwide. It is unknown whether morbid obesity independently affects postoperative complications and resource use after TKA. Emotional dissonance as stress factor was more prevalent among oncology health care workers. Welded tracheal stent removal in a child under cardiopulmonary bypass. Decrease in mortality occurred at a slower rate in the elderly population than in middle-aged population. The individual with blue cone monocromasy had only a red-green hybrid gene inactivated by a critical mutation in codon 203. Histological examination disclosed that the inner surface of the cystic part consisted of bi-layered epithelial lining, portions of which had changed to stratified squamous epithelium. Dom (Labiatae) which is used as an anticonvulsant in the Brazilian Amazon. One of the main obstacles that needs to be overcome is the development of systems that treat both information and knowledge as clinical objects with same modelling requirements.

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The objective of the present study was to develop cross-sectional reference values for S-IGF-I measured by an automated chemiluminescence immunoassay (Nichols Advantage). Comparison of base inclination of ribo-AU and deoxyribo-AT polymers. 1H MR spectroscopy detection of lipids and lactate in metastatic brain tumors. The goal of this prospective study was to determine the outcome of double level osteotomy of the knee performed after analysis with computer-aided preoperative planning software in patients with varus malalignment. The Golgi complex (GC) of mammalian cells is composed of stacks connected by tubular bridges to form a continuous membranous system. Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans. Juvenile angina pectoris erroneously diagnosed as cardioneurosis. Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. US forensic pathologists on a new case: examination of living persons.

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Living arrangements after divorce: cohabitation versus remarriage. When the trachea was opened, supplemental oxygen was administered via a modified cholangiocatheter placed into the distal segment. The possibility also exists that JNK and/or ERK pathways amplify a differentiation signal provided by 1,25D(3). Low employment and low willingness of being reemployed in Chinese working-age maintained hemodialysis patients. Contests over reproductive resources in female roller beetles: Outcome predictors and sharing as an option.

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Higher resting HRV is associated with more adaptive and functional top-down and bottom-up cognitive modulation of emotional stimuli, which may facilitate effective emotion regulation. The authors have experienced a low neurologic injury rate with this technique. Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. We aimed to determine their prevalence in samples referred for ANA testing and to identify factors predicting more specific reactivities. The method is simple, inexpensive and non-invasive, and it can be performed at bedside. After 2 h, granules from both dispersion patterns were retrieved equally. Indomethacin tablets made of two types of cross-linked polymers--very low water soluble and relatively high water soluble--were made and analysed for their water uptake and drug release characteristics.

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Combining mechanical and optical approaches to dissect cellular mechanobiology. Effect of triclosan and triclocarban biocides on biodegradation of estrogens in soils. Either glutathione S-transferase (GST) fusion proteins containing the SH2 domains of these proteins, or antibodies specific for these polypeptides, were microinjected into cells. Our Medical Library enters into this program by providing training in medical literature resources to students and staff involved in this program. Early infection and progression of cystic fibrosis lung disease. Calcium traces were analyzed for basal, peak and plateau responses. A loading dose of 200 mg/kg was infused over 30 minutes, followed by a maintenance dose of 20 to 50 mg/kg/h. Efficacy of early intensive rosuvastatin therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (ROSEMARY Study). No study sought to reduce maternal mortality associated with unsafe termination of pregnancy.

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Systolic hypertension is more strongly associated with cardiovascular disease than diastolic hypertension, and occurs more commonly in older people. These results demonstrate that comprehensive TP can be performed on FNA biopsies. The solubility of zinc, lead, cadmium and copper was very low in the mimicking salt solution even at very low pH values (up to pH 1) in agreement with the theoretical solubility of their discrete metal sulfides. Each member prepared a description of a model and the results were compared in two workshops. The enhanced areas were complementary to each other in the whole pancreatic head, including the tumor. A clear and present danger: endogenous ligands of Toll-like receptors. This study suggests that diffusion MR cannot detect alterations in NAWM of patients with a CIS suggestive of MS. This study was designed to evaluate quantitatively the inhibitory effects of argatroban on leukocyte- and platelet-endothelial cell interactions after transient retinal ischemia. Rate constants and activation parameters for the mobility of bulk and DNA-associated glycol-water solvents.

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On admission, he was in cardiogenic shock with the systolic blood pressure of 70 mmHg. Due to the potential severity of SARS in transplant recipients and the large number of cases of SARS in the community, in order to avoid transmission of SARS from a donor, we developed guidelines for SARS screening what type of drug is compazine of organ donors. Aspects of the optimisation of sampling procedure, sample preparation and analysis are described. The mechanical knot performance of Monocryl is identical to that of Vicryl, less than that of one other synthetic absorbable monofilament suture (Maxon) and comparable to or somewhat less than the other alternative (PDS-2). The stimulation of TLRs by microbial components triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent downstream signaling pathways. Males have consistently an earlier onset, poorer premorbid functioning and different premorbid behavioral predictors. Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide. Of interest is the finding that while higher doses of UV-B (500-700 J/m2) irradiation of BMC prior to transplantation into CsA-treated animals prevented hemopoietic reconstitution, lower doses (100-300 J/m2) allowed for hemopoietic recovery and, in addition, prevented the development of syngeneic GVHD following the discontinuation of CsA. The effect of EEBL on erythrocyte membrane and thrombocyte membrane fluidity were measured by fluorescence polarization.

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Three-dimensional analysis of eye movements induced by roll and pitch tilt. The right pedicles were dilated with stainless steel dilators and instrumented with screws of same dimension. Dependance of the substrate concentration in the heart on the glucose and ketone bodies concentration in blood of normal and alloxan diabetic rats. This means that not all of the NORs are transcriptionally active in non-stimulated lymphocytes and that these inactive NORs lie at a distinct distance from the active ones. Although beta-naphthoflavone did not exhibit any significant effect, phenobarbital significantly increased the activity and maximal velocity of indomethacin O-demethylation. This work investigates the role of the surface roughness of Ti6Al4V on the cell morphology, proliferation and adhesion, and in particular on the variation of the expression of cell adhesion proteins. Several reports in the literature have shown that, compared with endometrioid adenocarcinoma, patients with papillary serous (PS) and clear cell (CC) histologic features do worse. pH determination in body fluids using a cell with an isotonic sodium chloride bridge.

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Biblical interpretations of woman-to-woman sexuality are reviewed. The methanol and the fractionated extracts (hexane, chloroform, ethyl acetate, and water) of P. Interconvertible kinetic and physical forms of human erythrocyte pyruvate kinase. Treatment was discontinued in two of the patients after 12 months but was continued in the other five for 24 months. Congenital HPD deficiency is a rare, relatively benign condition known as hereditary type III tyrosinemia. Psychological and physical morbidity in the aftermath of a cyclone. In one case, an extended iliofemoral approach was tolerated in a coreg patient with absent superior gluteal artery flow. Two ways popularly used to measure lower esophageal sphincter pressure are the mid-respiratory and end-expiratory methods.

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Eighteen observational studies were reviewed, the results of which indicate that total dairy intake does not contribute to cardiovascular disease incidence or death. A comprehensive exploration of all possible cross-links posed a formidable computational problem. The effects of divergence and nonuniformity on the x-ray pencil-beam dose kernel. Cerebrovascular changes elicited by electrical stimulation of the centromedian-parafascicular complex in rat. Issues and prospects of microRNA-based biomarkers in blood and other body fluids. Phthalic anhydride as an impurity in industrial atmospheres: assay in air samples by gas chromatography with electron-capture detection. Oncostatin M is produced during pregnancy by decidual cells and stimulates the release of HCG.

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Treatment of human breast cancer cell lines in culture with SL11144 decreased cell proliferation and induced programmed cell death in a time- and dose-dependent manner. 1 alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3) enhances osteoclast precursor differentiation in vivo by mechanisms that are still not clearly understood but entail enhanced attachment of cells to bone. In many countries of the industrialised world second generation (atypical) antipsychotics have become first line drug treatments for people with schizophrenia. The amount of active ingredients in commercial products was determined from the amount of methylamine found. Solution conformation of bovine lens alpha- and betaB2-crystallin terminal extensions. Angioplasty and stenting may offer a useful alternative treatment for these patients. The CDDP-induced enhancement of K562 cell susceptibility to lysis by PBL also was observed when purified NK cells and LAK cells were used as effector cells.

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Sequence analysis by tandem mass spectrometry (MS/MS) was performed to confirm mapping assignments and to resolve possible ambiguities arising from the concomitant formation of isobaric products with identical base composition and different sequences. Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument. Parasite-driven dysfunctional adaptive immunity represents an emerging hypothesis to explain the chronic or persistent nature of parasitic infections, as well as the observation that repeated exposure to most parasitic organisms fails to engender sterilizing immunity. Neither SD nor LD exercise at the VeT increased short-term food intake and SD exercise attenuated increases in appetite. The alteration in virus activity in 1981 and 1982 was not associated with changes restricted to these 2 years in factors such as the age groups or sex ratio of patients affected or in the clinical categories predominantly affected. T3SS-OFF strains outcompeted WT PA103 in vivo, whereas a T3SS-ON mutant showed decreased fitness compared with WT. The use of PVP increased the aqueous solubility of the nonoxynol-9 formulations containing oligomers 1 to 18 and 8 to 10 slightly. Immunization with inactivated antigens of Neospora caninum induces toll-like receptors 3, 7, 8 and 9 in maternal-fetal interface of infected pregnant heifers. The performance of the neural network model was evaluated by computing their prediction error statistics of average value, standard deviation, root mean square and their correlation with the true data for normal, restrictive and obstructive cases. Bray has served in prison for the bombing of amethopterin ten abortion clinics in Washington, DC.

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Following partial amino acid sequence analysis, we have identified a complementary DNA encoding a 39-kD DNA-binding protein called pur alpha. Antibodies to prostaglandin were obtained by immunization of rabbits with PGA(1), PGA(2), and PGE(1), protein conjugates of prostaglandins. Intermediate filaments (IFs) are fiber-forming proteins and part of the cytoskeleton of eukaryotes. Nerve fibres were not observed at pulpal horn levels and in the ligamentous attachment. More disappointing was the failure to engage in a deep debate over development issues. Our data were at the lower range when compared with the available literature. The primary objective of this study was to develop a mathematical model to predict the monotonic tensile mechanical behavior of these sterilized components as a function of changes in density arising from oxidative degradation. The goal of this study was to confirm the effectiveness of our novel treatment strategy, neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy, which are performed before complete excision of residual tumor in patients with intracranial nongerminomatous malignant germ cell tumors (NGMGCTs).

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In summary, our data point towards a model in which specific inhibitors of DUBs not only interfere with virus spread but also increase the immune recognition of HIV-1 expressing cells. Residual kidney function (RKF) contributes significantly to solute clearance and fluid removal for dialysis patients, and the presence of RKF is associated with less morbidity and better long-term outcome. However, few studies have investigated age-dependent changes in the uterus. The design was based on previous evidence indicating that retrieval at short delays is easier leading to high-evidence mnemonic decisions, whereas retrieval at longer delays is more difficult but also more hippocampus-dependent. A working party lead by the University of Melbourne was established in 1998 to develop clinical indicators and a database for the RMH consultation-liaison service.

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Behavior of body weight in adult females of Gobra race (Senegalese peuhl zebu). High-energy eccentric excimer laser angioplasty for debulking diffuse iIn-stent restenosis leads to better acute- and 6-month follow-up results. Anticomplement action in vitro of animal phospholipids of various organs. Systemic booster immunization, through increasing the number of circulating TEM, increases lung TRM, providing a potential new avenue to enhance IAV vaccines. We used molecular analysis to determine the dominant species of SRB responsible for As thiolation. Parallel rise in the amount of glycolysis metabolites (pyruvate and lactate) in the blood and the decline in blood plasma glucose level were observed. Control and leukocytopenic rats received saline instead of ultram tab 50mg other drugs. Only the 0.5 mg/kg-day dose group showed any effect on serum hormones: a slight downward trend in thyrotropin levels in morning blood draws during perchlorate exposure, with recovery by P15. We expect that assessment of lung volumes, compliance, and resistance will become a routine part of management in children with life-threatening pulmonary diseases in the near future, and that a more intimate knowledge of the pathophysiology of respiratory disorders treated in PICU will lead to improved outcomes.

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