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Dosulfin

Dosulfin is a combination of two synthetic (man-made) antibiotics, sulfamethoxazole and trimethoprim. Both drugs reduce the ability of some bacteria to utilize folic acid for growing. Sulfamethoxazole is an anti-bacterial sulfonamide, a sulfa drug.

Other names for this medication:
Alfatrim, Anitrim, Assepium, Bactelan, Bacticel, Bactiver, Bactoprim, Bactrimel, Bactron, Baktar, Balkatrin, Biotrim, Colizole, Cotrim, Cotrimoxazol, Cotrix, Daiphen, Danferane, Diseptyl, Ditrim, Dosulfin, Ectaprim, Escoprim, Exazol, Globaxol, Groprim, Ifitrim, Infectrin, Kepinol, Letus, Megatrim, Methotrin, Metrim, Nopil, Nufaprim, Onetrim, Politrim, Primazole, Septran, Sulfa, Trifen, Trimecor, Trimethox, Trimetoger, Trisulfose, Urobactrim, Wiatrim, Xepaprim

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Also known as: Trimethoprim

Description

Dosulfin contains a combination of sulfamethoxazole and trimethoprim. Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria.

Dosulfin is used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.

Dosage

This section provides information on the proper use of a number of products that contain sulfamethoxazole and trimethoprim. It may not be specific to Dosulfin DS. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). .

For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (liquid or tablets): For treatment of bacterial infections: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 10 to 14 days. Your doctor may adjust this dose if needed. Children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 40 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 8 milligrams (mg) per kilogram of body weight of trimethoprim, given in two divided doses every 12 hours for 10 days. Weighing 40 kilograms (kg)—4 teaspoonfuls (20 mL) of oral liquid or 2 tablets (or 1 DS tablet) 2 times a day for 10 days. Weighing 30 kg—3 teaspoonfuls (15 mL) of oral liquid or 1 ½ tablet 2 times a day for 10 days. Weighing 20 kg—2 teaspoonfuls (10 mL) of oral liquid or 1 tablet 2 times a day for 10 days. Weighing 10 kg—1 teaspoonful (5 mL) of oral liquid 2 times a day for 10 days. Children younger than 2 months of age—Use is not recommended. For treatment of bronchitis: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended. For treatment of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults and children 2 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 75 to 100 milligrams (mg) per kilogram of body weight of sulfamethoxazole and 15 to 20 milligrams (mg) per kilogram of body weight of trimethoprim each day, given in equally divided doses every 6 hours for 14 to 21 days. Weighing 80 kilograms (kg)—10 teaspoonfuls (50 milliliters (mL)) or 5 tablets (or 2 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 64 kg—8 teaspoonfuls (40 mL) or 4 tablets (or 2 DS tablets) 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls (30 mL) or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls (25 mL) or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls (15 mL) or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 16 kg—2 teaspoonfuls (10 mL) or 1 tablet 4 times a day for 14 to 21 days. Weighing 8 kg—1 teaspoonful (5 mL) 4 times a day for 14 to 21 days. Children younger than 2 months of age—Use is not recommended. For prevention of Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP): Adults—800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim once a day. Children 2 months of age and older—Dose is based on body size and must be determined by your doctor. The usual dose is 750 mg of sulfamethoxazole and 150 mg of trimethoprim per square meter (m[2]) of body surface each day. This is given in equally divided doses two times a day for 3 days a week on consecutive days (eg, Monday, Tuesday, Wednesday). However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. Children younger than 2 months of age—Use is not recommended. For treatment of traveler's diarrhea: Adults—1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 5 days. Children 2 months of age and older—Use and dose must be determined by your doctor. Children younger than 2 months of age—Use is not recommended.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe nausea/vomiting/diarrhea, severe dizziness or drowsiness, mental/mood changes.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Side effects

The most common side effects associated with Dosulfin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Dosulfin is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency.

Dosulfin is contraindicated in pediatric patients less than 2 months of age. Dosulfin is also contraindicated in patients with marked hepatic damage or with severe renal insufficiency when renal function status cannot be monitored.

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Analysis of the mutant DnaK756 protein, which has a lower affinity for GrpE, reveals a role for residue Gly 32 in GrpE binding. This observational study describes the efficacy and safety of rituximab in 5 patients with voltage-gated potassium channel (VGKC)-complex/leucine-rich, glioma-inactivated 1 (LGI1) antibody-associated encephalopathy. Plasma concentrations of different local anesthetics after facial nerve block. The cGMP immunoreactivity seems to be contained within the nongranular type. Cell wall transferases utilizing beta-(1-3)-glucan chains as substrates may play important roles in cell wall assembly and rearrangement, as beta-(1-3)-glucan is a major structural component of the cell wall of many fungi. Factors associated with isolated anti-hepatitis B core antibody in HIV-positive patients: impact of compromised immunity. Responses of young women to gradually increasing and constant load maximal exercise.

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This review aimed to identify the trials using such instruments in order to guide the design of future trial-based cost-effectiveness studies. A theoretical model for the prediction of ambient noise level due to collective oscillations of air bubbles imdur 30 mg er tab under breaking wind waves is presented. Both diseases are linked to an alteration in chromosome 12, but this clinical association seems to be random rather than causal. In patients who are refractory to first-line therapy, tricyclic antidepressants (TCA) and selective serotonin reuptake inhibitors are both effective to obtain symptomatic relief, but only TCAs have been shown to improve abdominal pain in meta-analyses. Reflexology for the treatment of pain in people with multiple sclerosis: a double-blind randomised sham-controlled clinical trial. This confirmed that the layer staining with trypan blue was the basement membrane, a consistent feature on all the specimens. This paper compares 2 approaches aimed at producing an image on the basis of restricted data: the common source method and the effective aperture technique.

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He showed bradykinesia and small step gait with supranuclear vertical gaze palsy, especially upward gaze palsy. The authors describe their case studies and results on the implantation of various radial head prostheses. Approaching CPOE from a patient safety what is the prescription drug lamisil and care quality perspective is the first critical step toward success. The cytogenetic changes of osteosarcoma were much more complicated. Hemodynamic and cardiodynamic effects of lidocaine in a normal subject. A cohesive European policy for hepatitis B vaccination, are we there yet?.

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A computed tomography (CT) scan revealed an abnormal mass between the descending aorta and esophagus. Confocal microscopic study, however, indicated that NBD-labeled AmBisome was localized on the surface of the fungal cells at either temperature. There was no evidence of a protective effect of brief psychological therapy or educational booklets on preventing disability. A method of evaluating drug efficacy by statistical analysis of healing speed of peptic ulcer. Spontaneous decrease of a pilocytic astrocytoma in neurofibromatosis type 1. HEGESMA confirms the region encoding CD80, CD86, and interleukins on chromosomes 3 and 5.

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Insights about odour processing in the CNS of female mosquitoes should help us to understand how sensory information can lead to host-seeking behaviour. In contrast to the periphery, the immunoreactivity only accumulated on the proximal side of a lesion of the dorsal root. The values of tu averaged over ten 30ns-long trajectories for each solvent composition are shown to decrease very rapidly with addition of dimethyl sulfoxide, and rather small singulair montelukast sodium 10 mg amounts of dimethyl sulfoxide are found to change the pathway of unfolding. However, MHP before and during cold stimulation in mice that did not improve their cold tolerance as a result of the cold-acclimation procedure was significantly lower than the MHP of animals in which cold tolerance was improved, and was not different from MHP of the NAIVE group. One group consists of angle and posterior body fractures, the other group consists of anterior body, canine and symphysis fractures. Adaptive techniques in electrical impedance tomography reconstruction. Bromoacetophenone as an affinity reagent for human liver aldehyde dehydrogenase.

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The sizes of core, core-corona, and core-corona-shell particles were determined by TEM. Patients with tumors of low malignant potential and nonepithelial histologic diagnosis and those who received neoadjuvant chemotherapy were excluded. It also correlates with time between the first and subsequent operations. This report reinforces the need to consider a misplaced Essure device in the differential diagnosis of late-onset acute pelvic pain in women who had difficult placement of the device. Despite residing megabases apart, these tandem repeats make frequent inactive X-specific interactions. We have shown that ET-1 stimulates the adaptor protein p66Shc through Rac/Cdc42 guanine nucleotide exchange factor beta(1)Pix. Glycinergic synaptic transmission to bullfrog retinal bipolar cells is input-specific. As momilactone A and B are phytoalexic and allelopathic, the increasing secretion of momilactone A and B may be associated with the activation of the defense responses of H. Acquired hemophilia is a rare disorder due to spontaneous development of antibodies directed against the factor VIII molecule in patients with previously normal levels of factor VIII.

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To evaluate the pharmacokinetic profiles of aztreonam and imipenem in critically ill trauma patients with pneumonia. The highest levels of the Braunwald classification are associated with a greater size and intensity of myocardial perfusion and wall motion abnormalities and with the angiographic findings of complex morphology, intracoronary thrombus, and decreased TIMI flow. pFOS-LA: a modified vector for production of random shear fosmid libraries. The transport of sound and heat, in the form of phonons, can be limited by disorder-induced scattering. Our study suggests that insulinic therapy could be effective in slowing cognitive decline in patients with AD. Contribution of angiogenesis to the progression of colon cancer: possible inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and hepatic metastasis. Existing and future interventions on HIV prevention should focus on empowering young FSWs with innovative and sustainable approaches aimed at improving their health and wellbeing.

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Unexpectedly, schlank mutants also show reduction of storage fat, which is deposited as triacylglyerols in the fat body. As viral infection may alter macrophage functions, nitric oxide production was investigated in murine macrophages infected with a Flavivirus, tick-borne encephalitis virus. A total of 384 plaque samples were collected from 32 patients with chronic gastritis and chronic periodontitis, one supragingival plaque sample and one subgingival plaque sample from one tooth, totally 6 teeth having been examined for one patient. Pairwise comparison of amino acid composition in all analyzed taxons demonstrated high similarity between taxons from different subclasses and at different levels of biochemical specialization. We performed the surgical simulation to fix these structures with cementless cups and screws with angular eccentricities. Evaluation of a porcine dermal collagen (permacol) implant for abdominal wall reconstruction in a pediatric multitrauma patient. These distinct biological responses to NGF are controlled by receptors signaling from different locations within the cell. Bilateral acute arteritic anterior ischemic optic neuropathy during chronic steroid therapy. The results reveal an enormous growth of urban medical service demand in the future.

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