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Fasigyn (Tinidazole)
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Fasigyn

Fasigyn is indicated for the oral treatment of: Trichomonas vaginalis infections of the genitourinary tract in both female and male patients. When infection with Trichomonas vaginalis has been confirmed or is suspected, simultaneous treatment of the consort is recommended.

Other names for this medication:
Simplotan, Tindamax, Tinidazole

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Also known as: Tinidazole

Description

Fasigyn manufacturer is Pfizer. Fasigyn tablets contain active ingredient is Tinidazole, a 5-nitroimidazole anti-parasitic agent, which belongs to a drug class Amebicides, Antimalarials and gynecological Antiinfectives.

Dosage

Fasigyn tablets should be taken with plenty of water with or after meal. Swallow Fasigyn tablets whole, do not chew or crush. Fasigyn is not recommended for use in children less than 12 years. For urogenital Trichomoniasis: The recommended dose is 4 tablets (2 g) given as a single dose. For amoebic involvement of the liver (a liver infection): the recommended dose is 3 to 4 tablets (1,5 to 2 g) once a day for 3 to 6 days. For the infection associated with stomach ulcers: the recommended dose is 1 tablet (500 mg) taken twice a day. For most bacterial infections: the recommended dose is 4 tablets (2 g) on the first day then 2 tablets (1 g) once a day or 1 tablet (500 mg) twice a day. The usual length of treatment is 5 to 6 days. For bacterial vaginitis (a vaginal infection) and acute ulcerative gingivitis (a gum infection): the recommended dose is 4 tablets (2 g) given as a single dose. For vaginitis you may be given 4 tablets (2 g) on two consecutive days. For protozoal infections (intestinal amoebiasis): the recommended dose is 4 tablets (2 g) once a day for 2 to 3 days. Prevention of postoperative infections in adults (over 12 years): the recommended oral dose of 2 g approximately 12 hours before surgery.

Overdose

In acute animal studies with mice and rats, the LD50 for mice was >3600mg/kg and >2300mg/kg for oral and intraperitoneal administration respectively. For rats, the LD50 was >2000mg/kg for both oral and intraperitoneal administration.

Signs and symptoms of overdosage: There are no reported overdoses in humans with Fasigyn.

Treatment for overdosage: There is no specific antidote for treatment of overdosage with tinidazole. Treatment is symptomatic and supportive. Gastric lavage may be useful. Tinidazole is easily dialysable.

Storage

Keep all medicines out of the sight and reach of children.

Do not take this medicine after the expiry date stamped on the pack after EXP. The expiry date refers to the last day of that month.

Store below 25 C in a dry place. Store in the original package to protect from light and moisture.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Side effects

The most common side effects associated with Fasigyn are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Pregnancy: Fertility studies in rats receiving 100mg and 300mg tinidazole/kg had no effect on fertility, adult and pup weights, gestation, viability or lactation. There was a slight, not significant, increase in resorption rate at the 300mg/kg dose. Tinidazole crosses the placental barrier. Since the effects of compounds of this class on foetal development are unknown, the use of tinidazole during the first trimester is contraindicated. There is no evidence that Fasigyn is harmful during the latter stages of pregnancy, but its use during the second and third trimesters requires that the potential benefits be weighed against possible hazards to mother or foetus.

Breast-feeding: Tinidazole is excreted in breast milk. Tinidazole may continue to appear in breast milk for more than 72 hours after administration. Women should not nurse until at least 3 days after having discontinued taking Fasigyn.

No special precautions should be necessary. However, drugs of similar chemical structure, including Fasigyn, have been associated with various neurological disturbances such as dizziness, vertigo, ataxia, peripheral neuropathy (paraesthesia, sensory disturbances, hypoaesthesia) and rarely convulsions. If any abnormal neurological signs develop during Fasigyn therapy, the drug should be discontinued.

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Atrial tachycardia after ablation of persistent atrial fibrillation: identification of the critical isthmus with a combination of multielectrode activation mapping and targeted entrainment mapping. These data have paved the way for a translational programme aimed at a phase I clinical trial. However, the resultant effect of such induction on patient outcome has received limited study. The periacetabular region would be a fixed point around which the lower limbs and spine describe varying orientations. Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells. Systematic review and meta-analysis of relevant randomized controlled trials (RCTs) extracted from the Medline, Embase, and Cochrane Central Register of Controlled Trials databases. Methods of analysis for infant formula: Food and Drug Administration and Infant Formula Council Collaborative Study, Phase III. A 69-year-old man was diagnosed as having a malignant tumor in the retroperitoneum and underwent successful tumor extirpation. Recently developed methods attempt to go beyond anatomy to give information about the health and function of the kidneys.

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Despite considerable advances in medicine, the incidence of heart failure remains high in patients after myocardial infarction (MI). To compare traditional self-report measures of low back pain recovery with a quantitative measure of recovery. The production of nitrating species by the reaction between nitrite and hypochlorous acid. Modification of plastic surgery on the posterior urethra for its traumatic constriction. Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide. Altogether, our results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. Effect of dietary fluoride and aluminum on laying hen performance and fluoride concentration in blood, soft tissue, bone, and egg. Most clinical research in the United States has been carried out in atypical populations. The EGFR has been associated with the pathogenesis and progression of breast cancer.

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