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Glyburide (Glibenclamide)

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Glyburide is an effective and affordable medication for lowering blood sugar, but it can sometimes make your blood sugar too low especially if you have kidney problems. Glyburide tells your pancreas to increase the amount of insulin it produces in your body. Insulin works to lower your blood sugar.

Other names for this medication:
Afdiex, Aviglen, Benformin, Daocon, Daonil, Diabetnil, Diabnil, Dutrol, Euglucon, Glime, Glinil, Glitrac, Glucosil, Glutowin, Glybenclamide, Glybonil, Glybovin, Glycurub, Iscept, Melitus, Monomet, Sugnil, Sugronil, Sycored, Triglucored

Similar Products:
Zudena, Evista, Soma, Eldepryl, Motilium, Vermox, Pantoflux, Novidrine, Rozagel, Linox, Kopram,

Also known as: Glibenclamide


Glyburide is an oral diabetes medicine that helps control blood sugar levels.

Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glyburide is not for treating type 1 diabetes.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Glyburide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Glyburide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Glyburide and metformin if you are allergic to Glyburide or metformin, or:

severe kidney disease; metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment); or if you are also using bosentan (to treat pulmonary arterial hypertension).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glyburide and metformin.

Tell your doctor if you have ever had:

kidney disease; an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD); liver disease; or heart disease, heart attack, or stroke.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Glyburide and metformin for a short time just before your due date.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while taking Glyburide and metformin.

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Poly(2-hydroxyethyl methacrylate) sponges as implant materials: in vivo and in vitro evaluation of cellular invasion. Robust-linear-model normalization to reduce technical variability in functional protein microarrays. Evaluation of GH-IGF-I axis in adult patients with coeliac disease. Sixteen patients satisfying dementia criteria had atypical findings or findings suggestive of autoimmune encephalitis. We report on a patient with ring chromosome 7 analyzed by both high-resolution mid-prophase G-banding and fluorescence in situ hybridization (FISH) resolving a subband deletion of 7q36.3 associated with the clinical manifestation of holoprosencephaly (HPE). These included myoclonus, eye blink, head drop, cessation of ongoing activity, and hand and arm automatisms. Feeding with 100 or 150 mg caused statistically significant decreases in specific maltase and sucrase activities in duodenum, jejunum and ileum. With the rising incidence of cancer and with more terminally ill patients wishing to be cared for at home, it is clear that there is a growing need for general practitioners (GPs) who are skilled in providing palliative care. Wg secretion is regulated by a specialized mechanism involving a repertoire of proteins including Wntless (Wls).

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