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Isodem (Zolpidem)

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Isodem is the best sleeping tablets for insomnia patients. Isodem is a sedative, also called a hypnotic. It affects chemicals in your brain that may become unbalanced and cause insomnia. Isodem is used to treat insomnia.The immediate-release forms of Isodem are Ambien, Intermezzo, Edluar, and Zolpimist, which are used to help you fall asleep. The extended-release form of Isodem is Ambien CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep. Ambien, Edluar, and Zolpimist are used to help you fall asleep when you first go to bed. Intermezzo, is used to help you fall back to sleep if you wake up in the middle of the night and then have trouble sleeping.

Other names for this medication:
Ambiz, Ambulax, Azold, Dactive, Getrest, Insom, Inzofresh, Kayzole, Lipidem, Lopitas, Lypin, Nidra, Nitrest, Olpid, Sobrium, Stilnoct, Syzol, Zanlop, Zedem, Zleep, Zodem, Zolax, Zolcent, Zolfresh, Zolip, Zolit, Zolnex, Zolojet, Zolpel, Zolpiapt, Zolpid, Zolpidem, Zolpirest, Zolpistar, Zolpitrac, Zolsoma, Zoltar, Zolway, Zopid

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Also known as: Zolpidem


Isodem (zolpidem) is a sedative, also called a hypnotic. Zolpidem affects chemicals in the brain that may be unbalanced in people with sleep problems insomnia).

Isodem is used to treat insomnia. The immediate-release tablet is used to help you fall asleep when you first go to bed. The extended-release form, Isodem CR, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep.

Your doctor will determine which form of Isodem is best for you.


Use the lowest effective dose for the patient. The recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7–8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness.

The total dose of Isodem should not exceed 10 mg once daily immediately before bedtime. Isodem should be taken as a single dose and should not be readministered during the same night.

The recommended initial doses for women and men are different because zolpidem clearance is lower in women.


In postmarketing experience of overdose with Isodem tartrate alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Isodem's sedative hypnotic effect was shown to be reduced by flumazenil and therefore may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following Isodem overdosage, even if excitation occurs. The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Isodem is not dialyzable.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Isodem CR dosage information

Side effects

The most common side effects associated with Isodem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid taking Isodem during travel, such as to sleep on an airplane. You may be awakened before the effects of the medicine have worn off. Amnesia (forgetfulness) is more common if you do not get a full 7 to 8 hours of sleep after taking Isodem.

Avoid driving or hazardous activity until you know how zolpidem will affect you. You may still feel sleepy the morning after taking Isodem, and your reactions could be impaired. Wait until you are fully awake before you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Do not take this medicine if you have consumed alcohol during the day or just before bed.

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Models with a limited number of factors may work better than complex models when applied to a limited number of patients. Due to its epidemiology and incidence in the population, the most frequent tumor indications that lend themselves to gamma knife radiosurgery are meningiomas, acoustic neurinomas, pituitary adenomas and brain metastases. Hepatitis B virus superinfection in a patient with chronic hepatitis C receiving alpha-interferon treatment. Development of the lateral line canal system through a bone remodeling process in zebrafish. Further enhancement of health insurance schemes and scale-up of social pensions are an important component of bolstering the security of dependent older people and supporting their continued social and economic participation. We compared the times of select events documented in the medical record (PCR) with times from time-stamped audio recordings in the monitor-defibrillator (AUD). This is consistent with the observation that the mammalian PAR-1 homologues, the MARKs, dramatically reduce the number of microtubules, when overexpressed in tissue culture cells. Comparing vertebral to hip fractures the distinguishing variables were: vertebral BMD, height, NSA and HAL.

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Supernatant reduction of stored gamma-irradiated red blood cells minimizes potentially harmful substances present in transfusion aliquots for neonates. Water intake induced by subcutaneous furosemide or isoproterenol was not changed by LPBN-methysergide injections. Expression of pituitary adenylate cyclase activating polypeptide receptors in the early mouse embryo as assessed by reverse transcription polymerase chain reaction and in situ hybridisation. VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. The number of total ankle arthroplasties (TAAs) performed in the United States has risen significantly in recent years, as has utilization of orthopaedic specialty hospital (OSH) to treat healthy patients undergoing elective surgery. Somatostatin and octreotide in the management of acute variceal hemorrhage. The cells were evaluated with a semiquantitative scoring method. Different GMA patterns are associated with different gastric symptoms and there exist some nonlinear mechanisms to govern the formation and dynamic evolution of these patterns. The system has been developed using human alpha(2B)-adrenergic receptor (alpha(2B)-AR) expressed from Semliki Forest virus vectors in CHO cells.

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Proteinase assay by capillary electrophoresis employing fluorescence-quenched protein-dye conjugates. We genotyped the TG SNPs rs2069566, rs2076739, rs121912646, rs121912647, rs121912648, rs121912649, rs121912650, rs137854433, rs137854434, and rs180195 by MassARRAY SNP analysis using iPLEX technology in a cohort of 529 patients with thyroid autoimmunity with and without ophthalmopathy, and controls. DNA bending has been suggested to play a role in the regulation of gene expression, initiation of DNA replication, DNA packaging, and the recognition of specific DNA sequences by proteins. Persistence and vulnerability, which also play an important role in the priority setting process, are discussed briefly. Over the last 10 years, transoesophageal echocardiography has allowed the visualisation of the particularly frequent atheromatous involvement of the initial part of the aorta in patients suffering from cerebral as well as peripheral embolism. These results demonstrate that the increased expression of c-fos and c-myc mRNAs appears to be a common response to diverse agents that induce DNA synthesis and cell proliferation. To investigate the cause of disagreement within the large body of literature concerning the effect of exercise on the capacity of circulating neutrophils to produce reactive oxygen species (ROS), 10 male endurance-trained athletes underwent maximal exercise. Outcomes associated with pediatric after-hours care by call centers: a multicenter study. The accumulation of HIF-1alpha was not observed at the youngest ages, but was apparent in neurons of 9-month-old SHR and SP-SHR. Estimation of pressure gradients in pulsatile flow from magnetic resonance acceleration measurements.

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Granuloma inguinale: first case reported in the last four decades in China. Pseudotumor cerebri syndrome (PTCS) is a disorder defined by increased intracranial pressure in the absence of an intracranial space-occupying lesion. A retrospective evaluation of the treatment of 7 patients with Churg-Strauss syndrome. Visual outcomes were 20/30 or greater in all cases at 5 to 18 month follow up. Eighty genetic markers were anchored to the cytogenetic map, fixing all the genetic maps in the physically correct orientation. The purpose of this study was to evaluate the effect of a specific type of chiropractic treatment on the wet night frequency of patients between the ages of 3 and 18 years who were treated for primary nocturnal enuresis (PNE) in the chiropractic setting. Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats. The apparently reduced level of WHV replication intermediates and viral RNA in the reinfected liver grafts compared with the carrier animals was caused by the severe morphological changes leading to a replacement of hepatocytes by extended portal infiltrates. However, feelings of self-worth tend to be lowest for those with very little religious commitment rather than those with moderate levels of religious involvement. Using the determinant quantum Monte Carlo method, the temperature- and magnetic-field-dependent conductivity is calculated, as well as the degree of spin polarization.

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563 patients were included from the European Palliative Care Research Collaborative Study (EPCRC-CSA), an international, multi-centre, cross-sectional study. Although 23 of these peptides were active on all 3 cell types screened, 25 others showed cell-type specificity in their activity. Intermolecular alkyne hydroaminations involving 1,1-disubstituted hydrazines. In vivo micro-CT scanning of rat tibiae and morphometric analysis were performed at 0, 2, 4, 8, and 12 weeks after ovariectomy, with zoledronic acid treatment beginning 2 weeks after ovariectomy. Multiplicative genetic effects in scrapie disease susceptibility. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid peroxidation, and protein damage after chronic ethanol ingestion. Broad specificity in binding of NIPP-1, nuclear inhibitor of protein phosphatase-1, to PP1 isoforms in vivo. All 9 successfully rehabilitated patients reported a remarkable functional and psychologic improvement after the treatment.

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The activity of the new fluoroquinolone trovafloxacin (CP-99,219) was compared with that of ciprofloxacin and ofloxacin against 517 bacterial isolates representing 50 different species. After the treatment, ghrelin levels were not different from those of the controls. Clinical significance of soluble interleukin-2 receptor as a putative systemic nutritional index in the elderly. Coverage of the left subclavian artery in thoracic endovascular aortic repair is still a controversial procedure. A prognostic significance of nucleolar organizer region (AgNOR) in renal cell carcinoma. By having a better understanding of the role of macrophages in the tissue healing processes, especially in events that follow biomaterial implantation, we can design novel biomaterials-based tissue-engineered constructs that elicit a favorable immune response upon implantation and perform for their intended applications. We measured maternal circulating 25-hydroxyvitamin D (25-OH-D) and CRH from 97 samples collected from 15 early-preterm, 31 late-preterm, 21 early-term, and 30 term births. The results suggest that susceptibility to infection in obstructive jaundice is due to impaired phagocytic function of Kupffer cells. During carotid revascularisation, embolic material originating from unstable atherosclerotic plaques and thrombi forming within the stent is generated. Seasonal variability of mercury contents in street dust in Brno, Czech Republic.

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