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Lunesta (Eszopiclone)

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Lunesta is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is slightly effective for this use. Lunesta is the active dextrorotatory stereoisomer of Lunesta, and belongs to the class of drugs known as cyclopyrrolones. It is also classified as a therapeutic sedative hypnotic and pharmacological cyclopyrrolone.

Other names for this medication:
Bexomer, Eszopiclone, Fulnite, Zolnite, Zopimin, Zopipure

Similar Products:
Strattera, Claritin, Levlen, Azulfidine, Arimidex, Tofranil, Lodine, Exelon, Ditropan, Mericobal, Randor, Sebifin, Helmapax, Clomiphene, Combivir, Tagat, Escitozan,

Also known as: Eszopiclone


Lunesta is a nonbenzodiazepine hypnotic agent that is a pyrrolopyrazine derivative of the cyclopyrrolone class.

Lunesta is a white to light-yellow crystalline solid. Lunesta is very slightly soluble in water, slightly soluble in ethanol, and soluble in phosphate buffer.

Eszopiclone is formulated as film-coated tablets for oral administration. Lunesta tablets contain 1 mg, 2 mg, or 3 mg eszopiclone and the following inactive ingredients: calcium phosphate, colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide, and triacetin. In addition, both the 1 mg and 3 mg tablets contain FD&C Blue #2.


Usual Adult Dose for Insomnia:

Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 3 mg orally once a day immediately before bedtime Maximum dose: 3 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Usual Geriatric Dose for Insomnia:

Initial dose: 1 mg orally once a day immediately before bedtime Maintenance dose: 1 to 2 mg orally once a day immediately before bedtime Maximum dose: 2 mg/day Comments: -The lowest effective dose should be used. -Patients should be monitored for cognitive and/or motor impairments, especially if this drug is used repeatedly. -Patients should be reevaluated if insomnia persists after 7 to 10 days of treatment.

Detailed Lunesta dosage information


According to the U.S. Prescribing Information, overdoses of Lunesta up to 90 times the recommended dose have been reported in which the patient fully recovered. According to the May 2014 edition of the official U.S. Prescribing Information, fatalities have been reported only in cases in which eszopliclone was combined with other drugs or alcohol.

Texas poison control centers reported that during 2005–2006 there were 525 total Lunesta overdoses recorded in the state of Texas, the majority of which were intentional suicide attempts.

If consumed within the last hour, Lunesta overdose can be treated with the administration of activated charcoal or via gastric lavage.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Do not share this medication with others. It is against the law.

Side effects

The most common side effects associated with Lunesta are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There is an increased risk of increased central nervous system depression when it is used with eszopicolone including anti-psychotics, sedative/hypnotics, antihistamines, opioids, and antidepressants. There is also increased risk of increased risk of central nervous system depression with other medications that inhibit the metabolic activities of the CYP3A4 enzyme system of the liver. Medications that inhibit this enzyme system include nelfinavir, ritonavir, ketoconazole, itraconazole and clarithromycin. Alcohol also has an additive effect when used concurrently with eszopicolone. Eszopicolone is most effective if it is not taken after a heavy meal with high fat content.

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Atmospheric phase distribution of oxidized and reduced nitrogen at a forest ecosystem research site. The release rate of the fluorescent dye was controllable by changing the molecular weight and the monomer composition of the copolymers in vitro. In vitro studies identified Th1 cytokines, particularly IFN-alpha and IFN-gamma, as the principal cytokines responsible for this induction. Head injuries are a frequent cause of death and disability in western society with the first 72 h being an important period for prevention of further brain damage. Autophagy interplays with apoptosis and cell cycle regulation in the growth inhibiting effect of Trisenox in HEP-2, a laryngeal squamous cancer. Complicated urinary tract infections--from the perspective of the medical technologist. Interaction of septal lesions and experience on the suppression of punished responses. Further work is required to improve and evaluate arthroscopic techniques for the treatment of these injuries. Whether preceded by preeclampsia, or occuring without antecedent warning symptoms, eclamptic seizures usually occur in the antepartum period between 20 and 40 weeks of gestation or within a few hours to 2 days postpartum.

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Analysis of serum metabonome of patients with breast cancer by gas chromatography-mass spectrometry. The human cytomegalovirus (HCMV) DNA polymerase is composed of the UL54 catalytic subunit and the UL44 accessory protein. BIID subjects showed specific personality and interpersonal characteristics: high agreeableness, autonomy, autarky and restrained behaviour towards others. However, there is little standardization of dose-specification, fractionation and optimal dosage using this isotope, and homogeneous, objective analyses of the clinical results of treatment using iridium-192 is lacking. Potentially, the epidermis and dermis communicate by utilizing cell surface receptor expression, cell adhesion molecules, extra cellular matrix products, and chemical messaging via secreted molecules. The primary aim of this article was to assess the evidence for the effectiveness of Dutch evidence-based clinical guidelines in improving the quality of care. Intrauterine synechiae appear as bands of varying thickness traversing the uterine cavity.

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A comparative analysis of microRNAs expressed in normal and malignant GC B cells identified microRNA 28 (miR-28) as significantly down-regulated in BL, as well as in other GC-derived B-NHL. Commercial and custom programs developed and used in a typical multidoctor mixed species veterinary practice are described. This discrepancy may indicate that Japanese patients with SSc show a different genetic predisposition to TGF theolair -beta1. Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse. The data obtained led to the change of the diagnosis at presentation in 4/8 patients and to a more accurate description of the clinical picture in all patients. In vivo and in vitro experiments were conducted to investigate the effect of alpha-isoproterenol on the inner ear stria vascularis with intracellular cytochrome oxidase activity used as an index. However, expression of both genes, zntA and cadA, was diminished in the presence of CzcCBA.

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The absence of pure vergence and the slowness of the saccades in the combined movements could be due to a brainstem deficit specific to the vergence oculomotor system. Influence of experimental neurosis on the blood pressure of albino rats in desoxycorticosterone administration. Quasi-likelihood methods and generalized estimating equations (GEE), which model the marginal mean/variance relationship, also avoid strict distributional assumptions. Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications. Patient demographics, major diagnoses with associated International Classification of Diseases (9th rev.) codes, and aeromedical disposition recommendations were abstracted into a separate database for analysis. We demonstrate the application of the method using two different types of features: the outer cortical surface and major sulcal ribbons.

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