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Provigil (Modafinil)

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Provigil is used in the treatment of excessive daytime sleepiness (narcolepsy). Provigil improves wakefulness and helps you to stay awake. It reduces the tendency to fall asleep during the day, thus restoring the normal sleep cycle.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Cleocin, Klonopin, Hydrea, Rogaine, Avana, Diovan, Zofran, Tenormin, Lamisil, Glunas, Vandep, Lorista, Famtac, Distamine, Mecozol, Ubimax,

Also known as: Modafinil


How you take Provigil may depend on what you’re taking it for.


If you’re taking Provigil to reduce daytime sleepiness due to narcolepsy or sleep apnea, you’ll take it in the morning.

If you’re taking Provigil for shift work sleep disorder, you’ll likely take it one hour before your work shift.

Provigil will keep you awake for several hours, so you shouldn’t take it too close to your bedtime.

Taking Provigil with food

You can take Provigil with or without food. If the drug upsets your stomach, taking it with food might reduce this side effect. However, if you take it with food, Provigil might take slightly longer to start working.

Can Provigil be crushed?

Provigil tablets should not be crushed or split. If you’re having trouble taking Provigil, talk to your doctor or pharmacist about options that can make swallowing the tablet easier.


The Provigil dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Provigil to treat
  • your age
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for narcolepsy and sleep apnea

For daytime sleepiness caused by narcolepsy or obstructive sleep apnea, the typical dosage is 200 mg once a day in the morning. Higher doses are sometimes used, up to 400 mg daily. However, these doses may not be any more effective than 200 mg daily.

Dosage for shift work sleep disorder

For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.

Dosage for people with liver problems

If you have severe liver problems, your doctor will likely prescribe a lower dosage. The recommended dosage for people with this condition is typically 100 mg daily.

Dosage for seniors

Seniors may be more sensitive to the effects of Provigil, especially side effects. If you’re over 65 years of age, your doctor may prescribe a lower dosage.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. Remember that Provigil will keep you awake, so don’t take it unless you plan to be awake for several hours. If it’s close to your bedtime, skip the missed dose and take it the next day at the normal time.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Will I need to use this drug long-term?

Yes, Provigil is usually taken long-term by people with narcolepsy or sleep apnea. These are chronic conditions that often require long-term treatment to improve symptoms of daytime sleepiness.


If you overdose Provigil and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Provigil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Provigil can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Provigil and other medications

Below is a list of medications that can interact with Provigil. This list does not contain all drugs that may interact with Provigil.

Before taking Provigil, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Drugs that change the effects of Provigil

Several medications can lessen the activity of an enzyme called cytochrome P450 3A4 in your body. Taking these drugs with Provigil can cause your body to get rid of Provigil more slowly. This can cause more Provigil side effects.

Examples of these medications include:

  • antiviral medications such as:
    • cobicistat (Tybost)
    • darunavir (Prezista)
    • ritonavir (Norvir)
    • Viekira Pak, Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir)
  • antifungal medications such as:
    • fluconazole (Diflucan)
    • itraconazole (Sporanox, Onmel)
    • ketoconazole
  • antibiotic medications such as:
    • clarithromycin (Biaxin)
    • erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)
  • heart medications such as:
    • amiodarone (Pacerone, Nexterone)
    • diltiazem (Cardizem, Cartia XT, Diltzac, Taztia XT, Tiazac, others)
    • verapamil (Calan, Verelan)
Drugs that may be affected by Provigil

Provigil can increase the activity of an enzyme called cytochrome P450 3A4 in your body. This can cause your body to get rid of certain medications more quickly. As a result, these medications may become less effective.

Examples of these medications include:

  • oral contraceptives (consider using a backup method of birth control while taking Provigil, and for one month after stopping it)
  • cyclosporine (Neoral, Sandimmune)
  • midazolam
  • triazolam (Halcion)
Provigil can reduce the activity of enzymes called cytochrome P450 2C19 in your body. This can cause your body to get rid of certain medications more slowly. This may cause more medication side effects.

Examples of these medications include:

  • clomipramine (Anafranil)
  • diazepam (Valium)
  • omeprazole (Prilosec)
  • phenytoin (Dilantin, Phenytek)
  • propranolol (Inderal LA, InnoPran XL)
Many other medications may be affected when taken with Provigil. If you take other medications, talk to your doctor and pharmacist about how to avoid potential interactions.

Monoamine oxidase inhibitors (MOAIs)

Taking Provigil with monoamine oxidase inhibitors (MAOIs) might lead to dangerous side effects such as very high blood pressure, chest pain, severe headache, and increased body temperature. Provigil should not be taken within 14 days of using an MAOI.

Examples of MAOIs include:

  • isocarboxazid (Marplan)
  • linezolid (Zyvox)
  • phenelzine (Nardil)
  • selegiline (Eldepryl)
  • tranylcypromine (Parnate)

Taking Provigil with warfarin (Coumadin, Jantoven) may make your body get rid of warfarin more slowly. This may increase the effects of warfarin and increase your risk of side effects such as bleeding.

Provigil and herbs and supplements

Provigil may interact with certain supplements or herbal products you may be taking. Examples of these include:

  • acacia rigidula
  • bitter orange
  • green tea
  • guarana
  • hordenine
  • Indian snakeroot
  • octodrine
  • St. John’s wort
  • yohimbe

Taking Provigil with marijuana might change how marijuana affects you. Provigil alters enzymes in your body that control how quickly the body gets rid of marijuana chemicals that cause you to get high. This might increase or decrease the effects and side effects of marijuana.

Provigil and foods

Provigil may interact with certain foods you may eat.

Fruit juices

Drinking certain fruit juices, such as grapefruit juice and orange juice, while taking Provigil might change how your body handles the drug. This could increase the amount of Provigil in your body and increase your risk of side effects.

Foods and beverages that contain caffeine

Caffeine in foods and beverages might add to the stimulant effects of Provigil. This can increase the risk of stimulant-related side effects such as anxiety, nervousness, trouble sleeping, and others.

Examples of foods and drinks that contain caffeine include:

  • coffee
  • chocolate
  • soda
  • tea (such as black, green, and oolong)

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An experience of a case with perforation of an aneurysm in the anterior mitral cusp developing after aortic valve replacement. We report the management of 30 patients presenting with oligodontia. Apolipoprotein E hytrin medication alpha polymorphism and hyperlipemia in type II diabetics. The cross-buckled structure for stretchable electronic devices is expected to broaden the fields of wearable electronics, stretchable displays, and biocompatible applications. These were implemented in FORTRAN77 and tested for performance using a practical patient data file. Changes in the carbohydrate content of the KB cell during the growth cycle. A pelvic belt is most effective in a high position, while a tension of 100 N does not reduce laxity more than 50 N.

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Quasi-continuous ultrasound fields may enhance or suppress nucleation and the criteria to determine such effects are derived. Neither of these strains carries a luxI gene, but there are several luxR solos that might perceive AHL molecules. The patients were questioned daily from day 2 through day 5 by the same investigator and the severity of nausea or vomiting was scored on a numerical scale. Preventive effects of kudzu root on bone loss and cartilage degradation in ovariectomized rat. Tables showing the number of casualties throughout 1 year of the War of Attrition are presented. These achievements elevate the projects of a GDT-based neutron source on a higher level of competitive ability and make it possible to construct a source with parameters suitable for materials testing today. Higher levels of Cytomegalovirus antibodies are associated with lower levels of cognitive functioning in non-elderly adults. The spectrum of a molecule found inside white powder placed behind the lamb stomach tissue was detected as a fingerprint. Cyclic AMP regulates basement membrane heparan sulfate proteoglycan, perlecan, metabolism in rat glomerular epithelial cells.

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Dose dependently, MALP-2 prevented death from lethal TNF-alpha doses in TLR4(-/-) how to start differin gel but not in TLR2(-/-) mice, with protection lasting from 5 to 24 h. Patient empowerment in cancer pain management: an integrative literature review. These data indicate that intact and injured endothelial cells exert differing effects on NSCs, and suggest targets for stimulating regeneration after brain insults. A national network of sentinel hospitals that prospectively collects, time-trends, and reports additional influenza morbidity data would be useful to hospital administrators, hospital epidemiologists, infection preventionists, and public health officials. The gorilla incus resembles humans more closely in its metric dimensions, including functional length, perhaps as a result of the dramatically larger body size compared with chimpanzees. Epidemiology and assessment of health care services: new research trend. Membrane localization of N-acylphosphatidylethanolamine in central neurons: studies with exogenous phospholipases. This article provides some background information concerning the possibility of fetal noise-induced hearing less.

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Cumulative effects of mutations in newly synthesised mitochondrial aspartate aminotransferase on uptake into mitochondria. QOL was still reduced 3 and 13 years after ICU, compared to population scores. Finally, the importance of the P450 system is analyzed from the point of view of clinical practice. In addition to the total area of proximal ureteral cross sections, the proportion of lumen, epithelium, submucosa, and muscularis was determined. Odds ratio estimates of relative risk of neonatal encephalopathy associated with antepartum and intrapartum factors. The scapulothoracic crepitus resolved in 2 patients and decreased in 8 patients.

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There was one major peak of neurotrophic activity and this activity peaked early, about 3 to 6 hr after nerve injury. The results suggest that membrane trafficking events required for membrane growth generate sphingolipid-dependent signals. They received the nerve branches from the cervical and the upper thoracic branches of vagus nerve and cervical and upper thoracic segments of the sympathetic trunk. To describe the characteristic magnetic resonance imaging (MRI) findings of paraneoplastic autoimmune encephalitis in patients with new-onset status epilepticus. It is concluded, that in rats, vasopressin contributes to the neurogenic hypertension caused by baroreceptor denervation and NTS lesions. InVEST is an interactive and visual tool for constructing evolutionary trees from an ordered list of edges. Effect of ionic strength on the inactivation of micro-organisms by microwave irradiation.

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