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Sovaldi (Sofosbuvir)
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Sovaldi

Sovaldi is an expensive antiviral medication used with other antiviral medications to treat chronic hepatitis C infection. Sovaldi is an antiviral medication used for the treatment of chronic hepatitis C. It will not work for any other type of bacterial or viral infection.

Other names for this medication:
Sofosbuvir

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Also known as: Sofosbuvir

Description

Sovaldi (sofosbuvir) is an antiviral medication that prevents hepatitis C virus (HCV) from multiplying in your body.

Sovaldi is used to treat chronic hepatitis C in adults and children who are at least 3 years old.

Sovaldi must be given in combination with other antiviral medications (usually ribavirin with or without peginterferon alfa). It should not be used alone.

Sovaldi treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Sovaldi is sometimes used in people who also have HIV, or people who have liver cancer and are going to have a liver transplant. This medicine is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 1 or 4: Sofosbuvir, peginterferon alfa, and ribavirin for 12 weeks -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Genotype 1, 4: This regimen is recommended for therapy-naive patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Genotype 2, 3: Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The dose recommendations for genotype 1, 2, 3, or 4 should be followed for HCV/HIV-1-coinfected patients. -The manufacturer product information should be consulted for ribavirin tablet dose recommendations; with genotype 1 or 4, the manufacturer product information for peginterferon alfa should also be consulted for dose recommendations. -Sofosbuvir and ribavirin for 24 weeks can be considered for patients with genotype 1 infection who cannot use an interferon-based regimen; treatment decision should be guided by benefit/risk assessment for the individual patient. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: As a part of a combination antiviral treatment regimen, for the treatment of chronic HCV infection -In combination with pegylated interferon and ribavirin: For genotype 1 or 4 infection without cirrhosis or with compensated cirrhosis -In combination with ribavirin: For genotype 2 or 3 infection without cirrhosis or with compensated cirrhosis

Usual Pediatric Dose for Chronic Hepatitis C:

3 years or older: -Weight less than 17 kg: 150 mg orally once a day -Weight 17 to less than 35 kg: 200 mg orally once a day -Weight at least 35 kg: 400 mg orally once a day Recommended Regimen and Duration of Therapy: -Genotype 2: Sofosbuvir and ribavirin for 12 weeks -Genotype 3: Sofosbuvir and ribavirin for 24 weeks -Hepatocellular carcinoma awaiting liver transplantation: Sofosbuvir and ribavirin for up to 48 weeks or until liver transplantation (whichever occurs first) Comments: -Both regimens are recommended for therapy-naive and therapy-experienced patients without cirrhosis or with compensated cirrhosis (Child-Pugh A). -Therapy-experienced patients have failed an interferon-based regimen (with or without ribavirin). -The manufacturer product information should be consulted for ribavirin dose recommendations. -The same dose recommendations should be followed for HCV/HIV-1-coinfected patients. -The regimen for patients with hepatocellular carcinoma awaiting liver transplantation is recommended to prevent posttransplant HCV reinfection. Use: In combination with ribavirin, for the treatment of chronic HCV genotype 2 or 3 infection in patients without cirrhosis or with compensated cirrhosis

Detailed Sovaldi dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Sovaldi are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Avoid taking an herbal supplement containing St. John's wort.

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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Early extracorporeal life support as rescue therapy for severe acute respiratory distress syndrome after inhalation injury. Transient expression of acetylcholinesterase in fetal area V2 reveals the separate compartments that project to V4 (temporal directed pathway) and V5 (parietal directed pathway). Coherent stimulated Raman emission from a microcavity-excited optical resonator. The route of the upper screw runs obliquely forward in the plane parallel to the sacral plate. Deformity of the vertebral column and ribs and dilation of the renal pelvis were frequently observed after administration on days 7 to 9. In this study, the flanking regions of several human and mouse Ig V(H) and Ig Vkappa genes were analyzed extensively for the presence of MARs by in vitro matrix-binding assay, and for interaction with the MAR-binding proteins cut-like protein x/CCAAT-displacement protein (Cux/CDP), B cell regulator of IgH transcription (Bright), and special AT-rich sequence-binding protein (SATB1) by EMSA. Assessment of natural radioactivity levels and radiation hazards due to cement industry. It recommends that i) health professionals and officials be better educated about pain, palliation and opioids, ii) regulatory restrictions be updated in light of clinical and scientific evidence, iii) opioid procurement policies be adjusted to facilitate increased medical use, iv) medical charts and records be modified to routinely elicit and document patients levels of pain, and v) educational campaigns be developed to inform the public that moderate and severe pain can be safely relieved at the end of life and other stages of life. On the other hand, no mutagenic synergism was detected between MNU and X-rays, even in a relatively high X-ray dose range (up to 862 mGy). Despite ongoing challenges, tremendous progresses have been made in recent years for the synthesis of carbohydrates.

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Relationship between soil properties and patterns of bacterial beta-diversity across reclaimed and natural boreal forest soils. All tumours were successfully reached with two cases of complications. Measurement of aluminum in neuronal tissues using electrothermal atomization atomic absorption spectrophotometry. Higher doses of ZD 7114 and BRL 35135 produced no further increase in HSL activity and, in the case of BRL 35135, provoked symptoms of non-selective beta-adrenoceptor activation. The structures were determined by MS, IR and NMR spectroscopic analyses, (6E)-5-Tigloxy-9-hydroxynerolidol is reported here for the first time. The treatment of sphincter incontinence with periurethral silicone implants (macroplastique). Histologic investigation of hollow implants retrieved for psychological reasons. Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress.

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Characterization of monoclonal antibodies to a crystal protein of Bacillus thuringiensis subsp. According to an Orwellian account a briefly presented stimulus is seen and then forgotten, whereas by a Stalinesque account it is never seen. The Papp value suggests the moderate absorption characteristic of the compound. New binary solid dispersion of indomethacin with surfactant polymer: from physical characterization to in vitro dissolution enhancement. The place for environmental professionals in protecting and promoting health. Effect of exogenous bovine somatotropin on pubertal mammary development in heifers. Cloning of a cDNA encoding a developmentally regulated 22 kDa polypeptide from tobacco leaf plasma membrane. Coexistence of these two lesions may be accidental, but it is also possible that the arachnoid cyst was secondary to the neurinoma. Treatment consisted of 6 weeks of thoracic radiation, 2 Gy daily for 5 days a week for a total dose of 60 Gy. To demonstrate usefulness of single-crystal PEDOT nanowires, we fabricated an organic nanowire field-effect transistor array contacting the ultrahigh conductive PEDOT nanowires as metal electrodes.

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