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Zocor (Simvastatin)

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Zocor is an inexpensive drug used to lower levels of cholesterol and triglycerides in the blood. Zocor may also reduce the risk of heart attack or stroke in patients with risk factors for heart disease. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions.

Other names for this medication:
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Also known as: Simvastatin


Zocor is an HMG-CoA reductase inhibitor. Zocor is used to: reduce the risk of heart attack, stroke, and death due to coronary heart disease; reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina; low high cholesterol and triglycerides; increase high-density lipoprotein (HDL, "good") cholesterol levels. Zocor is also known as Imvastatin, Simlup, Simcardis, Ranzolont, Simvador. Zocor works by reducing the production of certain fatty substances in the body, including cholesterol. Generic name of Zocor is Simvastatin. Brand name of Zocor is Zocor.


Take Zocor exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Zocor is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Zocor, you may need frequent blood tests at your doctor's office.

You may need to take Zocor on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Zocor is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Zocor dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zocor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Zocor if you are allergic to Zocor components. Be careful with Zocor if you're pregnant or you plan to have a baby. Do not use it if you are a nursing mother. Be careful with Zocor if you suffer from low blood pressure, kidney problems, diabetes, serious infection, metabolism problems, hormonal problems. Do not use potassium supplements or salt substitutes. Avoid eating grapefruit or drinking grapefruit juice while taking Zocor. While taking Zocor, you can make laboratory tests (blood cholesterol levels, liver function tests, creatine phosphokinase blood levels) to monitor the condition of your health. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Be very careful when you are driving machine. Do not stop taking Zocor suddenly.

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To evaluate the interleukin-6 receptor inhibitor tocilizumab for the treatment of patients with polyarticular-course juvenile idiopathic arthritis (pcJIA). Extensive plexuses of labeled mossy fibers were observed in the hilus and adjacent pyramidal cell layer of non-irradiated dentate gyrus explants. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. On the initial magnetic resonance angiogram 3 intracranial aneurysms were detected in 3 patients. The diagnosis is based on simple clinical examination, although it is easily overlooked.

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Statistical teleodynamics is a mathematical framework that unifies three seemingly disparate domains-purpose-free entities in statistical mechanics, human engineered teleological systems in systems engineering, and nature-evolved teleological systems in biology and sociology-within the same conceptual formalism. Percutaneous FNB, routinely performed in large hospital centers, has a high diagnostic yield and a low complication rate. Studies on the influence of puromycin on the ultrastructure of neurosecretory cells in enchytraeus. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. When compared with unmodified LMB-2, both PEGylated immunotoxins showed similar cytotoxic activities in vitro but superior stability at 37 degrees C in mouse serum, a 5- to 8-fold increase in plasma half-lives in mice, and a 3- to 4-fold increase in antitumor activity. Based on these and earlier genetic results we propose that PleC and DivK are members of a signal transduction pathway that couples motility and stalk formation to completion of a late cell division cycle event. The aim of this study was to clarify the relative contribution of hats, masks and clothing to the control of wound contamination in both ultraclean (enclosed vertical laminar-flow) and conventional (plenum ventilated) airflow theatres. This paper describes a suture technique to correct nasal tip cartilage concavities.

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Indigenous and minority peoples and cultural safety: the role of Nursing Praxis. The curves were analyzed for ejection fraction, peak filling rate (normalized for end-diastolic counts and for stroke counts), time to peak filling rate and filling fraction in the first-third of diastole normalized for cycle length. Males were individually mated to successive females in a single session for one ejaculatory series each. The main cause of death in patients with intermittent claudication was cardiac disease. A new approach to defining regional work of the ventricle and evaluating regional cardiac function: mean wall stress-natural logarithm of reciprocal of wall thickness relationship. Superposition of the apoenzyme and holoenzyme crystal structures is used to determine a rigid rotation axis for closing of the cleft. Current guidelines recommend partial nephrectomy for the management of T1a tumours. In a retrospective study, we evaluated HPV genotyping and p16 expression as prognostic markers of overall survival (OS) and disease-specific survival (DSS) in patients diagnosed with American Joint Committee on Cancer (AJCC) stages I to III carcinoma of the anal canal. We derive an exact expression for the photocurrent of photo-emission spectroscopy using time-dependent current density functional theory (TDCDFT).

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Unexplained acute renal failure in a toddler: a rare complication of Epstein-Barr virus. Thus, the aim of this study was to compare the pretreatment cervicovaginal loads of A. Also, the noise bound for images synthesized with O less than or equal to TEs less than or equal to TE1 is minimized by making TE1 as short as possible. Acute catarrhal or catarrhal-hemorrhagic inflammation was found regardless of the colitis etiology (Shigella, Salmonella, Campylobacter, rotavirus). Fluorometric determination of the oral hypoglycemic agent -phenethylbiguanide using alkaline ninhydrin. New analogues of known illegal intoxicants are invisible to most forensic detection techniques, while the alleged natural status and the lack of avert acute toxicity make them appealing to a wide range of users. Convection, the main mechanism for drug transport between the intravascular and extravascular spaces, is mostly related to interstitial fluid pressure (IFP) and tumor blood flow (TBF). The views of participants in peer review groups were analysed, and categories evolved which identified differences in how they perceived the structure and function of group peer review. A preferable wetting of the polystyrene (PS) domains with poly(styrenesulfonate) (PSS)-coated PtCo nanoparticles (instead of residing in the space between the domains) is observed. Phase-contrast imaging provides visualization of altered cartilage regions invisible in absorption CT with simultaneous high detail of the underlying bony abnormalities.

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The regular reviewers (most of whom were unaware that a dedicated methodology and statistical reviewer would be reviewing the article) paid much less attention to methodology issues. Development of the performance measure for activities of daily living-8 for patients with congestive heart failure: a preliminary study. Phylogenetic analysis indicated that these two serpin genes were highly clustered with other serpins associated with the immune response in other insects. Using a cross-species comparison I examined the percentage of offspring sired within a litter (single paternity) and in social species the percentage of offspring sired by the dominant male (alpha paternity). Performance on the Verbal Fluency Test, as a measure of the ability of initiating processes, is reduced in depressed suicidal patients. The aim of this study was to identify the clinical course of incidental parathyroidectomies after thyroidectomy. In the last decade, hospital outbreaks involving KPC-producing K. In this work, we present numerical evidence that for generic nonintegrable systems these fluctuations scale with a universal power law D-1/2 with the dimension D of the Hilbert space. Global upregulation of genes encoding components of the respiratory pathway under conditions of intermediate oxygen suggested a regulatory mechanism to control these genes as a response to the need of more efficient energy production. In the one-cell embryo, PAR-2 is localized to the posterior cortex and is partitioned into the posterior daughter, P1, at the first cleavage.

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The proliferative effect of IFNT may constitute an additional mechanism that promotes luteal cell survival, thus, extending the luteal life span during early pregnancy in cows. Communication in health can contribute to all aspects of disease prevention and health promotion. Ethnic/racial minorities often live in neighborhoods that are not conducive to physical activity (PA) participation. Human metapneumovirus can lead to severe respiratory illness during pregnancy. Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo. Status of antithrombotic therapy for patients with atrial fibrillation in university hospitals. Hence, a second trial measured interleukin 1 (IL-1), IL-6 and vascular endothelial growth factor (VEGF) concentrations in serum, follicular fluid and granulosa cell cultures. The third patient achieved locoregional control in the ipsilateral breast and regional lymph nodes but relapsed in the contralateral axilla.

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X-ray microanalysis of intestinal chloride transport in vitro and in vivo. This review focuses on the ability of prostaglandins to exert anti-inflammatory, and therefore anti-ulcerogenic, effects in the gastrointestinal tract. Basolateral processes are rare in perinatal mice and do not attain their mature form until 3-6 weeks of age. Giant right ventricular metastasis of hypopharyngeal cancer complicated by ventricular tachycardia and cardiogenic shock. The TAT-TR fusion protein was purified using Ni-NTA-agrose and PD-10 desalting columns, and analyzed by SDS-PAGE. Brief experimentally induced seizures have been shown to increase the expression of mRNA encoding basic fibroblast growth factor (FGF-2) in specific brain regions. Roles of general medicine faculties in undergraduate medical education. Stability and biological variability of TARC in plasma were also assessed for clinical sample analysis and data interpretation. Group I, which served as the control received 0.2 ml/kg normal saline, Groups II and III received 0.5 mg/kg and 1.0 mg/kg body weight (BW) of nicotine respectively. In our current understanding of pancreatic carcinoma, these neoplasms can arise either sporadically or in familial clusters.

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We conducted linkage analysis and association studies using the microsatellite markers D16S298 and D16S403 and a single nucleotide polymorphism in the promoter region of the IL-4 gene (- 590C/T) in 406 Swedish families with at least two siblings affected with AD, in total 1514 individuals. However, in vivo, siRNAs are vulnerable to degradation by serum nucleases and rapid renal excretion due to their small size and anionic character. To gain insight into the strategy to target PBR ligand-drug conjugates to brain tumors, novel N-imidazopyridinacetyl-melphalan conjugates and the corresponding ethyl esters have been prepared and evaluated for their cytotoxicity in melphalan-sensitive human (SF126, SF188) and rat (RG-2) glioma cell lines. Case 1 underwent two lumpectomies in 3 years, but even now new lesions have developed. We present the preoperative findings on computed tomography and magnetic resonance imaging. Scavenging released PDGF-B also markedly augmented the analgesic effect of morphine. Thirty normal subjects and a patient with a left unilateral neglect were submitted to a straight-ahead pointing task in the three following trunk orientations: head and trunk aligned at 0 degree, and trunk rotated 15 degrees to the left or to the right relative to the head. Later responses were observed in activated conditions (weak force production, preparatory period) at a mean latency of 62.8 ms (SE 3.5 ms).

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Despite the large number of in vitro mutations that increase resistance to extended-spectrum cephalosporins in TEM-type beta-lactamases, only a small number occur in naturally occurring enzymes. albicans were visualized using a mixed-linker polymerase chain reaction (PCR) and a C. Toward resolution of the dependency-premature termination paradox for females in psychotherapy. After 16 years of medical treatment he developed a malignant sarcoma of the right distal thigh. Reverting to normoxic conditions readily restored endothelium-dependent and neurogenic relaxation. We posit that trapidil affects the intracellular signal transduction pathway PKC activity and c-fos expression in cells stimulated with serum containing growth factors. By using supershift assay, Ca/CRE-binding activity in the SCN was shown to contain not only CREB but also activating transcription factor-1 (ATF-1).

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To measure these responses, monitoring strategies including a range of antibody-based and cellular assays have been developed. We have found that cyclin D1 is expressed in STSP-arrested G1 fibroblasts but not in low-serum-arrested G0 fibroblasts, whereas cyclin-dependent kinase 4 (cdk4) and proliferating cell nuclear antigen (PCNA) are equivalently expressed under conditions of both STSP treatment and serum deprivation. In addition, we showed that a reduction of oxidative stress protected cells from CsA-induced apoptosis, and myoblasts that had survived after preexposure to CsA not only proliferated and differentiated reversibly but also gained resistance to subsequent CsA exposure. We propose and demonstrate optical logic operations using polarization encoding and wave mixing in photorefractive crystals. The lung responds stereotypically to many disparate insults, so a better conceptual construct of ARDS may be to consider it as one component of the multiple organ dysfunction syndrome. Solution behavior of amidine complexes: an unexpected bactrim dose uti pediatrics cis/trans isomerization and formation of di- and trinuclear platinum(III) and platinum(II) species. Ninety-one of 351 patients who received an aortic valve replacement (AVR) with the St. There are few recent data regarding blood micronutrient concentrations and supplementation in children on maintenance dialysis.

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The goals of cancer treatment and cancer prevention are to extend life expectancy and to improve quality of life in the years prior to death. This article seeks to explore the legal issues and concepts that arise when treating a minor, and to show how the courts and legal process may become involved. Interestingly there was a significant difference in locomotor activity between the two groups of animals that were subjected to maternal deprivation. To test whether material debunking widely shared myths influences knowledge and the intention to provide adequate help to others, and if such information reduces reading enjoyment. Results suggest that hyaluronan-mediated binding of blood cells might play a role in oral inflammations. In vivo 3-D distributions of electric fields in pig skin with rectangular pulse electrical current stimulation (RPECS).

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In patients with stable chronic heart failure, waltz dancing is safe and able to improve functional capacity and endothelium-dependent dilation similar to traditional aerobic exercise training. coli upon induction by 1 mmol/L IPTG and then purified with affinity chromatography. Diagnostic value of the monoclonal antibody to thyroid transcription factor -1(TTF-1) in CNS metastases. DCIS lesions containing a comedo or cribriform element are more likely to have microscopic spread and involvement of lobules and DCIS lesions containing a papillary element are likely to be multicentric, whether the pattern are predominant in the tumor or not. Relationships between mefloquine blood levels, gender, and adverse reactions. As a result of arthroscopic findings, 10 operative procedures were necessary. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. It decreases the severity of symptoms, diurnal variation of PEF, bronchial hyper responsiveness as well as improves pulmonary function.

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The purpose of this study was to describe the short-term clinical outcome of a new arthroscopic fixation technique for primary osteochondral talar defects: lift, drill, fill and fix (LDFF). The correspondence between the usual ambipolar and free diffusion coefficients and those related to the presence of two groups of ions is discussed. Early PPH remains a significant problem in obstetrics with serious maternal morbidity and mortality. In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone. Patients treated for tumors in the hypothalamic-pituitary region or treated with testicular irradiation or with high doses of alkylating agents had severe gonadal and sexual dysfunction. In XO mice on the other hand, oocytes surviving through pachytene increasingly show the X axis making a non-homologous association with itself or with an autosome. Of the 16 cows, 5 had elevated concentrations of serum calcium and 10 had decreased concentrations of serum magnesium. A series of angiographic analyses were performed, before SAH and on Days 7 and 14, to examine changes in the diameters of the ipsilateral internal carotid artery, middle cerebral artery, and anterior cerebral artery. The present study illustrates the wide variety and the long history of misconceptions related to children born with congenital malformations of the pinna and the external ear canal. The effects of infant diet (breast milk or formula containing 2, 30 or 60 mg/dl cholesterol) and subsequent dietary cholesterol (0.02, 1.0 or 1.7 mg/kcal) and fat (saturated or unsaturated) on heparin-releasable lipolytic activity from omental adipose tissue was estimated from 99 baboons of 5-8 years of age.

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Beta-transducing repeat-containing protein (betaTrCP) targets the ubiquitination and subsequent degradation of both beta-catenin and IkappaB, thereby playing an important role in beta-catenin/Tcf and NF-kappaB-dependent signaling. Extending the Scope of GTFR Glucosylation Reactions with Tosylated sumycin generic Substrates for Rare Sugars Synthesis. This may be of practical benefit to reverse the extensive use of the chest wall muscles and alleviate dyspnea in severe COPD. microRNAs (miRNAs) regulate numerous physiological processes such as cell division and differentiation in many tissue types including stem cells. Combining carmustine wafers, radiation, and temozolomide led to a significant increase in the median survival of patients with glioblastoma. However, the lack of portable refrigeration/freezing techniques (and the inviolate second law) limited the use of cryopreservation in every-day life, until the early 19th century. In the past 2 years, eight patients have undergone posterior semicircular canal occlusion at the Chicago Otology Group. Biomechanical treatment of traumatic foot and ankle injuries with the use of foot orthotics. In this study, we investigated the barrier properties of HSEs established with the keratinocyte cell line N/TERT (N-HSEs). Submucosal and intramural leiomyomata which distort the endometrial cavity clearly affect outcome.

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Application of acetylcholine in the presence of noradrenaline induced a relaxation and tension oscillations, both of which were negatively dependent on age and blood pressure. Frequencies and damping rates for a standing-wave mode are extracted and compared with theory. Confusion in the definition of a phylum has thus led to attempts to explain (especially from a developmental perspective) a feature that is partly inevitable, partly illusory. Two strains of Eeniella nana were examined for their partial base sequences of 18S and 26S rRNAs. This paper reviews the effects of TGF-beta1 type II (TGF-beta1 R II what is the highest dosage of effexor xr you can take ) receptor and IL-13 receptor alpha2 (IL-13 Ralpha2) on hepatic fibrosis. This is a retrospective cohort study of subjects with newly diagnosed IFG from the Singapore National Healthcare Group hospitals and primary care clinics from 1 January 2008 to 31 December 2010.

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The use of agroforestry crops is a promising tool for reducing atmospheric carbon dioxide concentration through fossil fuel substitution. Although endotracheal intubation, surgical crossfield intubation, and jet ventilation are standard techniques for airway management in tracheal resections, there are also reports of new approaches, ranging from regional anesthesia to extracorporeal support. Of the species studied, mice are the most efficient at metabolizing BD to the initial metabolite, the monoepoxide (BDO). Fabrication of chitosan/poly(lactic acid)/graphene oxide/TiO2 composite nanofibrous scaffolds for sustained delivery of doxorubicin and treatment of lung cancer. In our study, we analyzed the allelic frequency of XPD Lys751Gln polymorphism of the XPD gene and the correlation between its variant alleles with colorectal cancer in patients and control groups. Leuprorelin acetate 6-month depot demonstrates a higher value than leuprorelin acetate 3-month depot through saving medical costs and loss of productivity, as well as intangible costs saved for having one less injection when treating pre-menopausal breast cancer patients. Interlocking nailing without imaging: the challenges of locating distal slots and how to overcome them in SIGN intramedullary nailing. Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life--are they thyroid hormone endocrine disrupters?.

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Pathological analyses of specimens revealed recurrence of her primary ICC in both pancreas and lungs. Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease. We recorded somatosensory-evoked magnetic fields and potentials produced by painful intra-epidermal stimulation (ES) and non-painful transcutaneous electrical stimulation (TS) applied to the left hand in 12 healthy volunteers to compare cortical responses to noxious and innocuous somatosensory stimulations. Since 1993, the American College of Surgeons has sponsored an annual 6-day course entitled the Surgeons as Educators. Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells. The amplitude of the stretch reflex component - and the subsequent force enhancement - may vary according to the increased stretch-load but also to the level of fatigue. The mid-year estimates (MYEs) resulting from the 2001 Census have a sex ratio pattern differing from patterns in previous estimates. IFT-B and kinesin are associated to anterograde transport whereas IFT-A and dynein participate to retrograde transport. A subset of 14 patients continued maintenance treatment for 3.5 years to study the long-term effects of cyclosporine on renal function and structure.

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Applied psychometrics in clinical psychiatry: the pharmacopsychometric triangle. As determined by clonogenic assay, the chromophore served as the active part of the molecule, displaying potent cytotoxicity similar to that of intact C1027. Dynamic Proteomics: a database for dynamics and localizations of endogenous fluorescently-tagged proteins in living human cells. Organization of the work of a division for the forensic medical expert assessment of cadavers. In this double-blind study, we evaluated the cozaar overdose effects of a preferential inhibitor of the inducible isoform of cyclo-oxygenase-2, nimesulide, on the spinal nociceptive flexion reflex (RIII reflex) before and after administration of an NO donor in healthy volunteers. Type 1 Gaucher disease: identification of N396T and prevalence of glucocerebrosidase mutations in the Portuguese. The risk of NODAT development increases with time from transplantation. HPLC showed that most of the injected (125)I-mahogany (1377-1428) reached the brain intact, and capillary depletion with washout showed that most of it reached the parenchyma.

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This implies that SnO was responsible for a good bond between particle surface and 4-META coupling agent. Here, we present a multi-modal magnetic resonance imaging (MRI) atlas constructed from the brain of an adult female squirrel monkey. Maintenance on does pepcid interfere with thyroid medication (-)deprenyl facilitates the activity of the catecholaminergic system in the brain, and this effect, too, is unrelated to either its effects on MAO or on neurotransmitter uptake. A hallmark of highly malignant human gliomas is their infiltration of the brain. Carcinogen-associated error-prone DNA repair increases the mutation rate of active genes in cancer. Betulin is a pentacyclic triterpene found in many plant species, among others, in white birch bark.

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