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Zofran

Zofran is a medication used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, and surgery. Zofran works by blocking the actions of serotonin, a natural substance in your body, that may cause nausea and vomiting.

Other names for this medication:
Acidom, Domar, Donrid, Emeset, Emitus, Emtop, Odanse, Ondansetron, Ondar, Ondeo, Ondet, Ondon, Onsett, Ontron, Onzil, Osetron, Periset, Rancet, Ranidom, Ranon, Renol, Renty, Sanron, Supracetron, Tiron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Vorast, Xondmet, Zondan, Zonde

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Also known as: Ondansetron

Description

Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Zofran and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Zofran ODT may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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In the last years, hepatitis C virus has been known to be involved as a causative agent of so called essential mixed cryoglobulinemia. However, the motion profiles at L5/S1 segment during forward flexion were different from those during backward flexion. Therefore, this differential binding was not a function of the type I fimbrial shaft or the presence of other types of fimbriae produced by one strain but not the other. Successful repair of aortic and mitral incompetence induced by methylsergide maleate: confirmation by intraoperative transesophageal echocardiography. Disorders of the extra- and intracellular water and electrolyte household in delirium tremens. Insensitivity to external hydroxyl ions of Na efflux from the toad oocyte into K-free Ringer.

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Cisplatin did not elicit a stress response, in contrast to geldanamycin. The role of genes in tobacco smoking during adolescence and young adulthood: a multivariate behaviour genetic investigation. Newborn mice labeled at E15 and analyzed at P1 and P9 served as controls. A multicenter randomized double-blind study of enoxaparin compared with unfractionated heparin in the prevention of venous thromboembolic disease in elderly in-patients bedridden for an acute medical illness. Conversion of serine-48 to a glycine (S48G) resulted in a BPV-1 genome that was unable to replicate and had reduced transformation capacity. Differences in urinary incontinence symptoms and pelvic floor structure changes during pregnancy between nulliparous and multiparous women. The ability to bank fish embryos by cryopreservation could be crucial for preserving species diversity, for aquaculture (allowing circannual fish farming), and for managing fish models used in human biomedical research. Panic symptoms that persist are associated with worse depression outcomes in the maintenance phase.

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Comparison of the staining patterns of RET-PE10 with those of various cytoskeletal elements suggests that RET-PE10 may be associated with part of the intermediate filament network. For heart failure, new therapeutic strategies based on augmentation of the regenerative resources of the heart muscle are under evaluation. Previously unknown aspects of remodeling that might be revealed by the novel approach are discussed. Finally, the observation that dimorphism is thermally regulated suggests similarities between the lifecycle of C. Significant skeletal changes included anterior position of the maxilla and posterior position of the mandible. Increased ethanol elimination following administration of glucose: activation of the enzyme system or nonspecific gastrointestinal stimulation?. Alternative tests versus measurement of fasting plasma glucose and oral glucose tolerance test for diagnosis of pediatric type 2 pre-diabetes: a systematic review protocol. The results of the study showed moduretic 25/2 5 mg bula high diagnostic possibilities of the method in detecting ischemic foci in the brain. Intensive care units (ICUs) are generally considered epicenters of antibiotic resistance and the principal sources of outbreaks of multi-resistant bacteria.

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Probably as children between 3 to 6 years old have a magical concept of death, it makes it easier to talk about their terminal phase. No deviations of the observed allele frequency from Hardy-Weinberg equilibrium expectations were found for any of the systems studied. Deuterium spin probes of backbone order in proteins: 2H NMR relaxation study of deuterated carbon xanax dosage image alpha sites. Strong evidence of the formation of halogen bonds in the excited state is also presented, confirming the idea of symmetry-breaking-induced asymmetrical photochemistry. No cases of premature closure of the ductus arteriosus or persistent fetal circulation were seen. The predominant ocular findings were strabismus and blepharoptosis. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. The authors observed zolpidem-induced SRED in restless legs syndrome (RLS). Mammalian cells defective in Ku are hypersensitive to ionizing radiation due to a deficiency in DSB repair. Determination of the standard oxyhemoglobin dissociation curve in horses.

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GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR). Finally, some rational assembly modes in organogels were proposed and discussed. This article examines the legal setting and background under traditional criminal and civil law concepts of nontreatment of handicapped newborns. In recent years, high-throughput screening assays have become indispensable for early stage drug discovery because of the developments in synthesis technologies, such as combinatorial chemistry and automated synthesis, and the discovery of an increasing number of new pharmacological targets. Perforation of the esophagus electrocardiographically mimicking myocardial infarction. Where surgery was successfully completed further haemorrhage was prevented in eight out of nine affected pouches (89 per cent). This study shows that the psychosocial determinants of tobacco use may protonix dosing inpatient vary substantially between ethnic groups and cultural contexts.

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