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Zofran (Ondansetron)

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Zofran is a medication used to prevent nausea and vomiting caused by cancer medications (chemotherapy), radiation therapy, and surgery. Zofran works by blocking the actions of serotonin, a natural substance in your body, that may cause nausea and vomiting.

Other names for this medication:
Acidom, Domar, Donrid, Emeset, Emitus, Emtop, Odanse, Ondansetron, Ondar, Ondeo, Ondet, Ondon, Onsett, Ontron, Onzil, Osetron, Periset, Rancet, Ranidom, Ranon, Renol, Renty, Sanron, Supracetron, Tiron, Vomicare, Vomigo, Vomikind, Vomipra, Vomiven, Vomiz, Vomizen, Vorast, Xondmet, Zondan, Zonde

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Also known as: Ondansetron


Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. It is also used to prevent nausea and vomiting that may occur after surgery. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

Make sure your hands are dry. Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

Make sure your hands are clean and dry before and after using this medicine. Fold the pouch along the dotted line to expose the tear notch. While still folded, tear the pouch carefully along the edge and remove the film out from the pouch. Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole. Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (oral disintegrating tablets, solution, or tablets): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, 8 milligrams (mg) taken 30 minutes before starting cancer treatment. The 8-mg dose is taken again 8 hours after the first dose. Then, the dose is 8 mg every 12 hours for 1 to 2 days. Children 4 to 11 years of age—At first, 4 mg taken 30 minutes before starting cancer treatment. The 4-mg dose is taken again 4 and 8 hours after the first dose. Then, the dose is 4 mg every 8 hours for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—One 24-milligram (mg) tablet taken 30 minutes before starting cancer treatment. Children younger than 12 years of age—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—At first, 8 milligrams (mg) taken 1 to 2 hours before radiation treatment. Then, the dose is 8 mg every 8 hours. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) one hour before anesthesia is given. Children—Use and dose must be determined by your doctor. For oral dosage form (soluble film): For prevention of moderate nausea and vomiting after treatment with cancer medicines: Adults, teenagers, and children 12 years of age—At first, one 8-milligram (mg) film taken 30 minutes before starting cancer treatment. The second 8-mg film is taken 8 hours after the first dose. Then, one 8-mg film is taken two times a day (every 12 hours) for 1 to 2 days. Children 4 to 11 years of age—At first, one 4-milligram (mg) film taken 30 minutes before starting cancer treatment. The second and third 4-mg films are taken 4 and 8 hours after the first dose. Then, one 4-mg film is taken three times a day (every 8 hours) for 1 to 2 days. Children younger than 4 years of age—Use and dose must be determined by your doctor. For prevention of more severe nausea and vomiting after treatment with cancer medicines: Adults—24 milligrams (mg) or three 8-mg films taken 30 minutes before starting cancer treatment. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after radiation treatment: Adults—One 8-milligram (mg) film three times a day. Children—Use and dose must be determined by your doctor. For prevention of nausea and vomiting after surgery: Adults—16 milligrams (mg) or two 8-mg films taken 1 hour before anesthesia is given. Each film should be dissolved in the tongue before taking the next film. Children—Use and dose must be determined by your doctor.


If you overdose Generic Zofran and you don't feel good you should visit your doctor or health care provider immediately.


Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the unused soluble film in the foil pouch until you ready to use it.

Detailed Zofran dosage information

Side effects

The most common side effects associated with Zofran are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Zofran ODT may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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The RBE values for the nitrogen-ion beams were 0.45 for gaps, 0.43 for deletions and 0.20 for exchanges. The proposed classification uses a short, simple practical tool to assess different levels of low back pain. Our study shows that chronic pain is common and often results from injury. Our results suggest that elevated plasma levels of immunoreactive adrenomedullin are an independent predictor of prognosis in predominantly mild to moderate chronic heart failure treated by conventional therapy and provide additional prognostic information. On the importance of rehabilitation in chronic respiratory insufficiency in elderly patients. The NGOs have undertaken increasingly important activities in their countries. Birthweight, head circumference and crown-heel length, preterm delivery and low birthweight. Drugs that target multiple pathways or bifunctional agents that block intratumoral androgen biosynthesis and antagonize the AR offer the most promise.

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A quantitative analysis of mRNA expression of alpha 1 and beta-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders. Our results indicate that Ang II increases autophagy levels via activation of AT1 receptor and NADPH oxidase. To better understand this interaction, we created several truncation mutants of apoA-I and then followed up with more specific point mutants and helix translocation mutants to identify and characterize the locations of apoA-I required for ABCA1-mediated cholesterol efflux. The multipoint videoconference lasted approximately 4.5 hours and was attended by 16 APEC members who shared best practices in public-private partnerships for pandemic influenza preparedness planning. In order to evaluate certain assumptions of the method, diets with low and high levels of strontium were fed to male, virgin female, and pregnant female laboratory rats. By day 7, stroke volume was comparable to pretreatment values, whereas cardiac output was still increased.

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The subgroup B serotype Ad3 recognized a receptor distinct from the Ad2, 5, and 9 fiber receptor. Clonidine prophylaxis for narcotic and sedative withdrawal syndrome following laryngotracheal reconstruction. A single prolonged trial produced hyperalgesia which lasted for 30 min. These findings suggest that the abnormal production of MMP-9 by macrophages is a reflection of the pathological conditions in joints of patients with GA, and that the activation of MMP-9 in the joint is known to play an important role in joint disease. Time of day had an effect on cortisol, on progesterone only at one testing time, and no effect on testosterone. Diabetes-induced hyperglycemia increases the extracellular concentration of methylglyoxal. In the present study we examined whether olfactory information processing depends on the phase of the menstrual cycle. We report a case in which a critically ill patient developed a Brugada ECG pattern following high-dose propofol infusion.

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An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. The results of these devices allow us to study the vibroacoustic impact on the facade depending on the height. Bronchoscopic findings in a case of bronchopulmonary histoplasmosis. In relation to the number of vessels and muscular fibers, groups I, II and III were similar to each other and superior to group IV in the bladder and urethra. Furthermore, OLAARP formation seems to be an unavoidable process that should be considered as a last step in the lipid peroxidation process. Addition of laser did not lead to better functional outcomes or lower treatment need. Counselling, and referral to allied health professionals, were the only striking differences after multivariate analysis.

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PS-341 is currently in phase I/II clinical development in lung cancer. The resulting change in electron transfer efficiency is readily measured by cyclic voltammetry at target DNA concentrations as low as 10 pM. A retrospective study of the results of neoplastic cord compression was undertaken to determine the effectiveness of surgical treatment and to assess quality of life in patients undergoing extensive procedures with potential morbidity. We demonstrate that the Q/R site of GluRs in white matter is edited significantly less than in grey matter. The present review addresses these issues and aims to identify the cerebral regions differentially involved in low and high spatial frequency processing, and to clarify their attributes during scene perception. Time resolved in situ liquid atomic force microscopy and simultaneous acoustic impedance electrochemical quartz crystal microbalance measurements: a study of Zn deposition.

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In the last years, hepatitis C virus has been known to be involved as a causative agent of so called essential mixed cryoglobulinemia. However, the motion profiles at L5/S1 segment during forward flexion were different from those during backward flexion. Therefore, this differential binding was not a function of the type I fimbrial shaft or the presence of other types of fimbriae produced by one strain but not the other. Successful repair of aortic and mitral incompetence induced by methylsergide maleate: confirmation by intraoperative transesophageal echocardiography. Disorders of the extra- and intracellular water and electrolyte household in delirium tremens. Insensitivity to external hydroxyl ions of Na efflux from the toad oocyte into K-free Ringer.

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The induction of HA-specific immune responses by the vaccine is necessary for full protection from challenge, because animals immunized with an empty rVSV vector were not protected equally. C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease. However, a targeted survey precluded grazing as a cause of decline for seven of these based on low palatability and positive responses to grazing and other disturbance. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Percutaneous coronary intervention (PCI), although not routinely recommended for treating vasospastic angina, can be considered for discrete coronary spasm that is not amenable to vasodilator therapy. During the past decade, humans with disturbed estrogen signaling, either as a result of ER alpha or aromatase deficiency, have been reported.

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Cisplatin did not elicit a stress response, in contrast to geldanamycin. The role of genes in tobacco smoking during adolescence and young adulthood: a multivariate behaviour genetic investigation. Newborn mice labeled at E15 and analyzed at P1 and P9 served as controls. A multicenter randomized double-blind study of enoxaparin compared with unfractionated heparin in the prevention of venous thromboembolic disease in elderly in-patients bedridden for an acute medical illness. Conversion of serine-48 to a glycine (S48G) resulted in a BPV-1 genome that was unable to replicate and had reduced transformation capacity. Differences in urinary incontinence symptoms and pelvic floor structure changes during pregnancy between nulliparous and multiparous women. The ability to bank fish embryos by cryopreservation could be crucial for preserving species diversity, for aquaculture (allowing circannual fish farming), and for managing fish models used in human biomedical research. Panic symptoms that persist are associated with worse depression outcomes in the maintenance phase.

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Finally, we describe a direct interaction between Gag and dynein light chain 8 that probably accounts for the specific routing of the incoming capsids to the centrosome prior to nuclear import of the viral genome. Going With the Flow: An Aid in Detecting and Differentiating Bronchopulmonary Sequestrations and Hybrid Lesions. Centers for Disease Control and Prevention guidelines for the treatment of sexually transmitted diseases: an opportunity to unify clinical and public health practice. Recently, the introduction of 3-D ultrasound has made reproducible investigation of plaque morphology possible, providing a reliable plaque surface analysis. The drop in red blood cell production was secondary to the decrease in the erythroid progenitor cell pool and to impaired proliferative capacity. A comparison of wind-mediated escape behavior of two species of cockroaches revealed striking differences. Improving clinical outcomes in treating heroin dependence: randomized, controlled trial of oral or implant naltrexone. The three types of toxins bound exclusively to three kinds of gangliosides, GD1a, GD1b, and GT1b, in both the thin layer chromatography plate and the microtiter plate methods. By analyzing the velocity trace we found that the movement consisted of a chain of small saccades, each tramadol hcl tab 50mg generic of which started before the previous one ended.

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Comparison of the staining patterns of RET-PE10 with those of various cytoskeletal elements suggests that RET-PE10 may be associated with part of the intermediate filament network. For heart failure, new therapeutic strategies based on augmentation of the regenerative resources of the heart muscle are under evaluation. Previously unknown aspects of remodeling that might be revealed by the novel approach are discussed. Finally, the observation that dimorphism is thermally regulated suggests similarities between the lifecycle of C. Significant skeletal changes included anterior position of the maxilla and posterior position of the mandible. Increased ethanol elimination following administration of glucose: activation of the enzyme system or nonspecific gastrointestinal stimulation?. Alternative tests versus measurement of fasting plasma glucose and oral glucose tolerance test for diagnosis of pediatric type 2 pre-diabetes: a systematic review protocol. The results of the study showed moduretic 25/2 5 mg bula high diagnostic possibilities of the method in detecting ischemic foci in the brain. Intensive care units (ICUs) are generally considered epicenters of antibiotic resistance and the principal sources of outbreaks of multi-resistant bacteria.

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HIV-1 p24 antigen testing was introduced to increase sensitivity in the early detection of HIV infection in blood donors. We demonstrate a solid-state nanopore assay for the unambiguous discrimination and quantification of modified DNA. Treatment rocaltrol tab with antiresorptive agents bisphosphonates, and the newly approved denosumab, a receptor activator of nuclear factor kappa-B ligand (RANK-L) inhibitor, has been shown to reduce the risk of skeletal-related complications and prevent treatment-induced bone loss in patients with advanced prostate cancer. In contrast, mutations of HBx affecting its functional interaction with general transcription factors abrogated the HBx-induced activity of NF-AT1. Using DB6, these same samples display acceptable histograms and low frequency of variant cells. The significance of methemoglobin and hemichrome formation is discussed, and a probable hypothesis for the hemolytic anemia is suggested. Zero-inflated Poisson regressions were utilized to estimate male-female differences in the number of AUD clinical features once it occurs. The International Congress on Biomedical Peer Review and Global Communications, 1997. We report a case of fetal supraventricular tachyarrhythmia with hydrops detected at 32 weeks that was managed with combination of oral digoxin and sotalol and review management guidelines available in the literature. Plasma DHP followed the opposite pattern, being low in fish sampled early in the run and high in fish sampled late in the run.

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GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR). Finally, some rational assembly modes in organogels were proposed and discussed. This article examines the legal setting and background under traditional criminal and civil law concepts of nontreatment of handicapped newborns. In recent years, high-throughput screening assays have become indispensable for early stage drug discovery because of the developments in synthesis technologies, such as combinatorial chemistry and automated synthesis, and the discovery of an increasing number of new pharmacological targets. Perforation of the esophagus electrocardiographically mimicking myocardial infarction. Where surgery was successfully completed further haemorrhage was prevented in eight out of nine affected pouches (89 per cent). This study shows that the psychosocial determinants of tobacco use may protonix dosing inpatient vary substantially between ethnic groups and cultural contexts.

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