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Zozep (Clonazepam)
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Zozep

Zozep is one of the products that belong to the bensodiazepine group and have a strong sedative effect. Zozep helps to stop convulsions and epileptic seizures. It is widely used among people with severe panic attacks and anxiety caused by depression treatment.

Other names for this medication:
Almac, Azpax, Catier, Clodep, Clonasig, Clonatrac, Clonax, Clonazepam, Clonoasig, Clonzy, Clopam, Closis, Clotas, Clotweet, Clozep, Clozipam, Clozorix, Cozil, Epcon, Escitapax, Esitor, Klopam, Melzap, Nazee, Nexclo, Nupam, Ozepam, Revozip, Xenotril, Zepam, Zeptril, Zicam, Zozep

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Also known as: Clonazepam

Description

Zozep (clonazepam) is a benzodiazepine. It is thought that clonazepam works by enhancing the activity of certain neurotransmitters in the brain. Clonazepam is also a seizure medicine, also called an anti-epileptic drug.

Zozep is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome in adults and children.

Zozep is also used to treat panic disorder (including agoraphobia) in adults.

Dosage

Adults. The initial dose for adults with seizure disorders should not exceed 1.5 mg/day divided into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 mg. The use of multiple anticonvulsants may result in an increase of depressant adverse effects. This should be considered before adding Zozep to an existing anticonvulsant regimen.

Pediatric Patients. Zozep is administered orally. In order to minimize drowsiness, the initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day but not to exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by no more than 0.25 to 0.5 mg every third day until a daily maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the largest dose should be given before retiring.

Geriatric Patients. There is no clinical trial experience with Zozep in seizure disorder patients 65 years of age and older. In general, elderly patients should be started on low doses of Zozep and observed closely.

Overdose

Symptoms of clonazepam overdosage, like those produced by other CNS depressants, include somnolence, confusion, coma and diminished reflexes.

Treatment includes monitoring of respiration, pulse and blood pressure, general supportive measures and immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of levarterenol or metaraminol. Dialysis is of no known value.

Flumazenil, a specific benzodiazepine-receptor antagonist, is indicated for the complete or partial reversal of the sedative effects of benzodiazepines and may be used in situations when an overdose with a benzodiazepine is known or suspected. Prior to the administration of flumazenil, necessary measures should be instituted to secure airway, ventilation and intravenous access. Flumazenil is intended as an adjunct to, not as a substitute for, proper management of benzodiazepine overdose. Patients treated with flumazenil should be monitored for resedation, respiratory depression and other residual benzodiazepine effects for an appropriate period after treatment. The prescriber should be aware of a risk of seizure in association with flumazenil treatment, particularly in long-term benzodiazepine users and in cyclic antidepressant overdose. The complete flumazenil package insert, including CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, should be consulted prior to use.

Flumazenil is not indicated in patients with epilepsy who have been treated with benzodiazepines. Antagonism of the benzodiazepine effect in such patients may provoke seizures.

Serious sequelae are rare unless other drugs or alcohol have been taken concomitantly.

Storage

Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Zozep are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clonazepam in the elderly. However, elderly patients are more likely to have confusion and severe drowsiness, or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving clonazepam.

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Effects of long-term antihypertensive treatment on cerebral, thalamic and cerebellar blood flow in spontaneously hypertensive rats (SHR). Findings suggest that older drivers view themselves as having better driving skills and attitude towards driving compared to when they were younger and compared to other drivers. MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma. Retrospective studies clearly indicate that mobile genetic elements (MGEs) play a major role in the in situ spread and even de novo construction of catabolic pathways in bacteria, allowing bacterial communities to rapidly adapt to new xenobiotics. The availability of an accurate 3D model represents a powerful tool for the design of new TmArgBP suited for biotechnological applications. Both intention-to-treat and completer analyses will be conducted. PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones. For clinical situations that can be modeled by a uniform phantom, reducing the x-ray tube voltage rather than increasing the exposure level would best achieve improvements on our DSA imaging system performance.

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Similar phenomenon was observed in the caspase-3-deficient MCF7 cells upon expressing procaspase-3 transiently. Syncatalytic modification of a functional tyrosyl residue in aspartate aminotransferase. The dangerous gamble of heparinization within two weeks of nonoperative traumatic acute subdural hematoma in patients with increased stroke risk: a case series. Helmeted motorcyclists are less likely to die and develop a deficit in speech after a motorcycle collision. SCBI.IMPORTANCE The opportunistic Gram-negative bacteria of the genus Serratia are widespread in the environment and can cause human illness. Benign proliferative nodules in GCN may clinically and histologically mimic a malignant melanoma. DNA-adduct formation in lungs, nasal mucosa, and livers of rats exposed to urban roadside air in Kawasaki City, Japan. The subjects were trained in the intervention through a single session of tai chi exercise class for one hour weekly, for 12 weeks, with a training compact disc (CD) that helped the patients to exercise at least twice a week at home.

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Three members, PACE4, PC4 and PC5, exhibit alternative splicing of their RNAs resulting in the generation of multiple isoforms differing in their C- or N-terminal segments. We performed a descriptive study of a series of cases analysing 32 interventions in children and adults with the modified Eavey technique, during the period from January 2012 to November 2016. Insensitivity of PI3K/Akt/GSK3 signaling in peripheral blood mononuclear cells of age-related macular degeneration patients. Medical personnel working in intensive care often face difficult ethical dilemmas. Three false positive and two false negative CT findings were recorded, resulting in a 91 per cent accuracy for CT, a diagnostic specificity of 84 per cent, and a sensitivity of 95 per cent. The Compare-Acute trial of fractional flow reserve-guided multivessel angioplasty in myocardial infarction. While BPD families enter treatment with more impaired children and more extensive treatment histories, both BPD and MDD/DD families benefit from intervention.

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To compare right ventricular volume measurements and their reproducibility between steady-state free precession (SSFP) and conventional turbo gradient-echo (TGE) imaging. The study was performed as a part of a larger research project on health and functional aging. Log rank analyses were used to ascertain the difference between the curves for each categorical variable. Although the SSRIs may cause abnormal hemostasis, this effect is probably rare. We analyzed IL-24 expression on the mRNA and protein level in stimulated rat and human macrophages.

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The sagittal arm has two musculotendon actuators, two neural oscillators that generate burst signals as motoneuron inputs, and spindles and Golgi tendon organs for extrinsic reflex feedbacks. Often, it is the question to the medical expert, if there is a causality in the lawful sense from professional effort or psychical stress to acute coronary death or acute myocardial infarction. Decreasing serum alpha-fetoprotein levels in predicting poor prognosis of acute hepatic failure in patients with chronic hepatitis B. We report the case of a 7-month-old girl with pulmonary dysplasia receiving inhaled nitric oxide who had cyanosis caused by methemoglobinemia after prolonged use of a eutectic mixture of local anesthetics cream. Case histories and structured questions were used to assess current practice. The ability of E7 to separately override each of these inhibitory signals, via cd1 and cd2, cosegregates with its ability to fully transform rodent fibroblasts. Full-thickness wear-through of the metal-backed acetabular shell after total hip arthroplasty is unlikely in patients who receive adequate follow-up after operation. The advantages of microlaparoscopy are: smaller incisions, less risk of damage to pelvic organs and less postoperative pain. What causes the variation of polarization degree across the emission spectrum of proteins?. In some studies, HT-29 cells were pre-treated with a commensal strain for 2 hr prior to infection or flagellin stimulation.

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Partial least squares regression (PLS) was chosen as the calibration method. An important one-day meeting on several issues affecting prisoners with HIV and/or hepatitis is being sponsored by the ACLU. There is a dramatic, sustained rise in depressive symptoms as AIDS develops, beginning as early as 18 months before clinical AIDS is diagnosed. A methyl group can be present at position 7 of the pyrrolo-quinoline ring. Effects of different types of antismoking ads on reducing disparities in smoking cessation among socioeconomic subgroups. Future strategies in the diagnosis of patients with coronary artery disease--are we stenting the wrong coronary artery lesions?. However, the inability of these drugs to prevent the uninhibited detrusor contractions of the unstable bladder consistently and objectively was demonstrated. MDC numbers were similar in healthy individuals and in patients with allergy.

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To investigate the efficacy of argon laser trabeculoplasty (ALT) for the treatment of primary open-angle glaucoma (POAG) and of glaucoma associated with exfoliation syndrome (EXF). Problem-based learning, description of a pedagogical method leading to evidence-based medicine. Data suggest that hair alterations are primarily related to food deprivation since hair follicle measures of all skin areas were more affected than the distal hair measurements. Release of surgically induced astigmatism required relaxation of the suture. Metabolism of trimethoquinol and pharmacological activities of its metabolites. In screening for CHD, combining amaryl medication class carotid IMT measurement with plaque assessment is better than using either measurement alone, but the improvement in discrimination is not sufficient to make carotid ultrasound screening for CHD worthwhile. However, non-gonadal sex steroids may regulate winter territoriality (e.g. The Wilcoxon ranked sum test was used to detect differences in PCT and SA. Based on these findings, surgical treatment was limited to corrective osteotomy. The imprinted multimembrane-spanning polyspecific transporter-like gene 1 ( IMPT1) encodes a predicted protein with organic cation transport capabilities.

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The proliferative effects of GH may be reflected in the increased incidence of neoplastic colonic polyps in individuals with long-term GH excess reported by some investigators. Successful treatment of posttransplant lymphoproliferative disorder with renal graft preservation by monoclonal antibody therapy. Moreover, this technique is safe, inexpensive and easy to perform. THC, the major psychoactive component of marijuana, has been shown both in humans and experimental animals to have immunomodulatory properties. Identification was based on the presence of one characteristic m/z ion (Q) obtained with the low collision energy function and at least one fragment ion (q) obtained with the high collision energy function, both with mass errors of less than 5 ppm, and an ion intensity ratio (q/Q) within the tolerances permitted. However, it also implies that, for high magnetic fields, granular gases could have a very different behaviour from colloidal liquids. Positron-emission tomography (PET) measures of neural activity were acquired while subjects viewed photographs of fearful or happy faces, varying systematically in emotional intensity. A variety of N-CAM isoforms are known, and individual N-CAMs undergo posttranslational modification. A 56-year-old man presented with progressive weakness of the right leg and the right arm.

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To assess the therapeutic effect of stimulating oropharyngeal sensory afferents with TRPV1, TRPA1, or TRPM8 agonists vs increasing bolus viscosity in older and neurologic patients with OD by comparing four studies of similar experimental design. This analysis provides further insight into the outcome of long-term treatment of generalised anxiety disorder with venlafaxine XR and shows for the first time that long-term treatment might be necessary to achieve and maintain remission of symptoms. The majority did not intend to practice CAM modalities but valued skills to generic glucophage xr 500 mg assess them. Random-effect models were used to estimate percent changes in UFP and BC concentrations with interquartile changes in each candidate predictor adjusted for meteorological factors. Graded image segmentation of brain tissue in the presence of inhomogeneous radio frequency fields. To characterize the effects of intravitreal injections of iodoacetic acid (IAA) in comparison to its systemic application as a measure to induce unilateral photoreceptor degeneration. Human papillomavirus-specific serologic response in vulvar neoplasia. Thereafter, each group was divided into two groups as young and old animals. There is a significant association between BMI and HRQoL in men and women in the general population.

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DC/SLC-IL-2 can promote DC proliferation, while TC-DC/SLC-IL-2 and TC-DC/SLC could strongly enhance significant cytotoxicity against bladder cancer cell that was induced by the coculture of DCs (transfected with SLC and IL-2) and TC. The phase-variable phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2) is an unusual bacteriophage resistance mechanism that confers protection against the temperate phage phiC31 and homoimmune relatives. Despite the controversial results on the relationships between cholesterol levels and affective disorders, the majority of literature seems to show a more consistent relationship between cholesterol levels and suicidal behaviour, with few studies that have found no relationships. viverrini ES products to induce proliferation of murine fibroblasts and a human cholangiocarcinoma cell line in vitro, indicating that Ov-GRN-1 is the major growth factor present in O. Violence against women: just a social issue or a global public health concern?. Renal replacement therapy in the elderly patients in the Gdansk Pomeranian region. Co-culture of primary human endothelial cells (EC) and vascular smooth muscle cells (vSMC) results in assembly of a network of tubular endothelial structures enveloped with vascular basement membrane proteins, thus, comprising the three main components of blood vessels.

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It is proposed that these proteins may share a similar three-dimensional conformation despite the lack of significant sequence similarity. Gene editing is increased by homology-directed repair in the presence of a repair template. Medical therapy in children with functional constipation and solitary encopresis is primarily based on clinical experience. EGF also induced cell proliferation of the fetal reproductive tract in a dose-dependent manner and a combination of physiological dosages of EGF and androgen-induced cell proliferation synergistically, suggesting an interactive effect of these two drugs. The correct diagnosis and preventive measures, together with the correct anti-epileptic treatment are in favour of a good prognosis in the great majority of patients. Using previously published data for maximum motrin dose per day the dose-rate as a function of distance from a point source of activity, dose-rate profiles through five sizes of tumors (radii: 10 microm, 50 microm, 100 microm, 500 microm, 1 mm) for six different radionuclides ((188)Re, (186)Re, (32)P, (90)Y, (67)Cu, (131)I) were calculated. The final protein preparation is free of interfering compounds based on its well-resolved 2-DE patterns. Self-assembling vanadium oxide nanotubes by organic molecular templates.

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Study of involuntary skeletal muscle function (MFA) has been well accepted in the area of nutrition assessment and potentially offers a means for following progress of the critically ill patient. TNF-alpha inhibitors (infliximab, adalimumab and etanercept) have demonstrated efficacy either as monotherapy or in combination with other anti-inflammatory or disease modifying anti-rheumatic drugs (DMARDs). High density measurements of hearing threshold from 3000 to 6000 Hz provided qualified support for the derivation of the forward-going sound pressure wave. Taken together, the results of this study suggest that the transient recruitment of K protein to serum-responsive loci depends on the inducible transcription of these immediate-early genes. Development of a method to measure synthesis de novo of RNA-purine nucleotides in Caco-2 cells, relying an the incorporation of 14C-glycine into the purine ring of the nucleotide. The adsorption process of foulants onto membrane surfaces and their aggregation process within membrane pores during the microfiltration of protein and polysaccharide solutions were clearly monitored. nidulans, all of them up-regulated by concanamycin A, we found two proteins with described homologues in other fungal species. Strong melting and recrystallisation, or unusually flat surfaces with open dentinal tubules were obtained with sequences of three pulses without water cooling. The aim of our work was to find risk factors for the development of significant cSDH requiring surgery following conservative treatment of trauma-related aSDH. This is a retrospective study of Streptococcus suis infection in humans submitted to the National Streptococcal Referrence Center of Thailand from 1994 to 2001.

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Spontaneus activity and effect of oxytocin on the islated uterus of liolaemus gravenhorti and liolaemus tenuis t. We aimed to identify CNVs associated with fasting glucose and fasting insulin. Economic factors in cancer palliation--methodologic considerations. This activation mechanism offers an explanation for the observed meprin-alpha activity in the tumor stroma, a prerequisite for a potential role of this protease in colorectal cancer. However, this method is impractical for early stage drug development because the test in humans is expensive and the taste of a drug candidate may not be important to the final product. Epithelioid granuloma cells with huge incorporated multinuclear elements were covered mainly by T-lymphocytes. The follow-up period ranged from 1 month to 8 years (mean 4 years). The latter two ingredients appear to be mutually reinforcing and contributed to the creation of meaningful student-teacher relationships. Calves were vaccinated SC or by aerosal exposure on days 0 and 7 with live or killed P multocida or phosphate-buffered saline solution (control) and subsequently challenge exposed with virulent P multocida.

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Aged participants showed significantly lower startle magnitude and significantly more habituation than younger participants, but there was no effect of age on PPI or prepulse facilitation. The study was completed at The Johns Hopkins University School of Medicine, a tertiary care institution, in the departments of gyn/ob and surgery. Modeling the active process of the cochlea: phase relations, amplification, and spontaneous oscillation. OCT is used to measure thickness of the retinal nerve fiber layer. White matter hyperintensity reduction and outcomes after minor stroke. The repair of the VA-PICA junction was urgently performed with successful exclusion of the aneurysm. TMJ disc related does norethindrone 5 mg cause weight gain diseases are difficult to be cured due to the poor repair ability of the disc. Measuring the value of program outcomes: a review of multiattribute utility measures. This context conditioning showed both extinction and latent inhibition, demonstrating that these simple worms with only 302 neurons are capable of associative context conditioning. The central nervous system (CNS) of MS patients fosters B cell survival, at least partly via BAFF and APRIL.

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